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Retired NBME 23 Answers

nbme23/Block 4/Question#32 (reveal difficulty score)
A 42-year-old woman comes to the office ...
Spontaneous regression ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +12  upvote downvote
submitted by โˆ—thomasalterman(181)
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Patient has a ganglion cyst, which can spontaneously regress.

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medschul  Mine would beg to differ >:O +36
usmleuser007  Where would I have come across something like this (FA, Pathoma, or out of my S)? +5
motherfucker2  I thought this bitch was a lipoma. Mother fucker +11
divya  mf2 lipomas is fat. although fat may exist in liquid form, its still opaque, therefore negative transillumination. unlike ganglion cyst. +5
beanie368  Only knew this because I have one that comes and goes... +4
cbreland  I thought these were like a 1-way valve? Didn't think it would regress if that was a case? +
yesa  I had that exact ganglion cyst because of too much multichanneling in lab, it would go away if I didn't use my hand for a while but then come back if I did. Had to get it surgically removed during first year of med school... +
an1  So this is particularly stupid. I initially opted for regression but then remembered seeing cases in surgery rotations and in family med rotations. Ganglion cysts need triamcinaole steroid injections to reduce in size and often reappear. Also, they can grow and impinge nerves causing parasthesia. But sorry if NBME wants to make up stuff that clashes with IRL scenarios +
an1  @motherfucker2 transluminates means there's fluid in there. lipoma is made of fat, it would not transluminate +



 +11  upvote downvote
submitted by โˆ—nwinkelmann(366)
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FA 2019 page 453: Ganglion cyst = Fluid-filled swelling overlying joint or tendon sheath, most commonly at the dorsal side of the wrist. Arises from herniation of dense connective tissue..

FA doesn't discuss long-term prognosis/course.

Per this article (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682407/), the ganglion cysts fluid is due to extra-articular mucin droplet accumulation. It also indicates 50% undergo spontaneous resolution. On examination, wrist ganglion are usually 1โ€“2 cm cystic structures, feeling much like a firm rubber ball that is well tethered in place by its attachment to the underlying joint capsule or tendon sheath. There is no associated warmth or erythema and the cyst readily transilluminates.

To rule out the other options:

A. Per the above article, these aren't really cysts because there is no lining: "It should be emphasized that since no synovial lining exists in these structures, they cannot be classified as true cysts. Though there are focal areas of mucinous degeneration in the cyst wall, neither significant global degenerative changes, necrosis nor inflammatory changes within the pseudocyst or surrounding tissues have been demonstrated" = A is wrong as it wouldn't have malignant potential.

B. Honestly not sure how to rule this answer out because if it compressed the superficial radial nerve branches, theoretically it could cause paresthesias. That being said, the couple of articles I've read have only indicated potential paresthesia due to ganglion cyst being due to dorsal cysts, NOT volar cysts. C. Based on these pictures (http://bit.ly/30hccjo, http://bit.ly/30loCH4, http://bit.ly/30kFrBV, and http://bit.ly/30qahZN), volar ganglion cysts (as this patient has) do not cause extensor retinaculum nerve entrapment, and thus are unlikely to produce radial nerve palsy. Also, the radial nerves closes to a volar ganglion cyst, seem to be cutaneous as opposed to motor, so if they did cause compression, it would likely only lead to sensory deficit, not motor deficit.

D. Yes, 50% spontaneously regress.

E. Synovitis = no because it is not an inflammatory condition

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apc  One thing to correct, this is a dorsal cyst (not volar). Dorsal normally doesn't have compression sx, but volar can be in contact with neurovascular structures (median nerve or radial artery) & may need ultrasound-guided aspiration +7



 +6  upvote downvote
submitted by joexoticsprintedshirt(6)
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I'd seen a Question just like this one on Amboss and still managed to get this one wrong. So basically a ganglion on the VOLAR (palmar) surface of the wrist could potentially compress the structures within the carpal tunnel (i.e the median nerve, the flexor pollicis longus, the flexor digitorum profundus and superficialis tendons) and cause weakness/paresthesias if it kept growing. A DORSAL ganglion, on the other hand, is a lot less likely to compress on anything, and is more likely to remain asymptomatic and regress spontaneously. P.S. Carole did it.

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jbro47  Wait? On the other hand or same hand? +



 +2  upvote downvote
submitted by jinzo(15)
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I have ganglion cyst since 2012 and this shit doesn't disappears . Moreover , it may cause some pain , when I flex my wrist . So why answer is not parasthesia???

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asharm10  I am sorry bus this is soo funny!! I hope your's spontaneously regresses too +6
lowyield  Not sure exactly but my guess is that it doesn't impinge upon any major nerve (yes it can probably impinge some superficial branches of the radial) +2



 +1  upvote downvote
submitted by โˆ—syoung07(58)
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In good southern terms this is a "bible cyst". You can take a book and smack it over this thing and it will go away. Its just a collection of your synovial fluid (which is why it transilluminates). A lot of these can stick around for a long time but most regress with time.

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 +0  upvote downvote
submitted by euchromatin69(16)
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check out uw 18661

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