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NBME 23 Answers

nbme23/Block 3/Question#30

A 20-year-old woman comes to the physician because ...

C1q

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 +6  upvote downvote
submitted by notadoctor(107),

SLE is associated with deficiency of early complement proteins(eg. C1q, C4, C2). (FA 19, pg. 462)

tinydoc  Am I the only one who has never heard of C1Q? +12  
llamastep1  I knew SLE is related to low complement but when it talked about a "mutation" it threw me off. +  




 +3  upvote downvote
submitted by thomasalterman(116),

Complement is important for removing immune complexes, so patients with complement deficiencies *(c1-c4) are more likely to develop SLE. C1q is a better answer than than MBL (D) b/c the MBL pathway is triggered by bacteria.

myoclonictonicbionic  Thats the reason I put MBL, because the question mentioned that it got worse when she went to the beach so I was thinking some sort of contact with bacteria may have exacerbated her immune system. +  
thotcandy  @myoclonictonicbionic i think that's just the typical SLE photosensitive malar/butterfly rash +  




 +2  upvote downvote
submitted by axsa19(5),

C1q, C1r, and C1s form the C1 complex. Any time you see C1 with any of these three letters "qrs" think of C1 which is the first component of the classical complement pathway





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