Transfusion reactions are mediated by Type II hypersensitivity reactions. These occur due to preformed antibodies that bind to the foreign antigen (AB group on RBC) and lead to hemolysis by NK cells. This is a form of Antibody dependent cellular cytotoxicity.
focusExactly! And among the blood transfusion reactions, per FirstAid:
allergic/anaphylactic reaction: type 1
(we would see urticaria, wheezing, etc. Seen in IgA deficiency.)
febrile nonhemolytic transfusion reaction: type 2
(host antibodies against donor HLA and WBCs)
acute hemolytic transfusion reaction: type 2
(ABO blood incompatibility)
TRALI: its separate category
(donor antibodies against recipient neutrophils and endothelial cells)
They specifically told us ABO incompatibility (despite the respiratory symptoms that could indicate TRALI) so we know this is an acute hemolytic transfusion reaction.+2
submitted by โyotsubato(1208)
Transfusion reactions are mediated by Type II hypersensitivity reactions. These occur due to preformed antibodies that bind to the foreign antigen (AB group on RBC) and lead to hemolysis by NK cells. This is a form of Antibody dependent cellular cytotoxicity.