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NBME 23 Answers

nbme23/Block 2/Question#3 (44.9 difficulty score)
A prospective study is done to assess the ...
Include the outcome for each participant in the group to which he or she was randomizedπŸ”
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 +4 
submitted by divya(58),

okay but where in the question is it asking whether it's intention to treat or per protocol or as treated???

are we to assume its ITT if they don't mention anything or the part of the question that says "primary analysis" the giveway to ITT??

kpjk  I had the same doubt. I think if we were to consider "per protocol" then answer would have to be a mash of options A and B. There is no option that would be right for per protocol +  
peqmd  I think ITT is assumed b/c it's the one that has reduced biased in measurements. +  



 +4 
submitted by osgoodschlatter10(27),
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ehT oniuqtse etsm nnotmeis 3 btesuss fo ne t)is:tapa omSe stietpan rewe cetsniintsno tihw katgin otiacnedim or nt"o detha"ern to iicomadten mbigere)n emSo sientpta etddisiouncn teh gurd htey ewer nzamoieddr ot lpt c)emcyelo A sbstue fo etshe ntpieats ni ptoin 'b', woh opptsde eth oeciiatndm were enth rriecpseb teh eaimctoidn rfom eht msoiaoprcn pogru.

ehT elmttuia ieqtnous orvehew is nreaidrgg hehwret tspniate ruedn oipnt ''a(sa eob)va suhodl be ldunidec or dx.eldcue

ylIaedl isth epsdnde ponu uryo ytusd roo.olctp In seencse yuo yam evha na nnI'ienott ot etatr clto'ropo ro na hedA'rten co'oo.rplt sA ptar fo na eehardnt oortcopl ouy nlyo iucdlen tpinaets or dtysu tcejsbsu as( feeerrdr to in ibsca cneseic a)ehcerrs yuo yonl leidncu otseh ttiepsna htta rsyticlt foldeolw hte cotlropo and luedxec eynevoer .eles hTis is myoslt owh csbia cineecs cltposroo rea eeidgsdn.

itWh aiclncil arecersh vwoereh egnbi oyleptelcm epr opocotrl si iulfifdct and sath't ewerh teh tnttnnro-aieetiot- roopolct esalpp. ihsT si to mcadatocmoe eht esebvtjciu aerunt of namuh bcjssteu ni illcnaic rceehas.r nlFloiwgo up ihtw nmahu csjsuetb si utb bivosou rdaehr hatn llyuanam dnnghial ciem or igps in teh al.b oS in cshu ecsas sa ognl sa the dstyu team sah leloodwf colpoort in inagconttc hte ntpitae nad lapygin rieth relo lal taeitpn daat acn eb lciedudn even if eerth ear eoms orimn rltpcooo odeavisnit eud to lscaglioit ssiues. All heste seodnativi need to be eteoprdr ot het BIR cusoorfe dna dcfeeiips in het mtrnupsiac ni hte osmt oiapetrarpp n.enram




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I got iths noe ogr,wn tbu adseb no teh TTI prvcpseeeit hreost deie,motnn ybmae hte n"i irhet rmypira sasal"nyi tarp of hte iteqosun si a ipt .fof Tyhde' rtsat tiwh udcngnlii hmet ni eth lrnioiag rspgou nda then od iondtildaa anslasiy to tyr nad teaes uto teh tapm?ci IKD




 +2 
submitted by adong(94),

By default you should use intention to treat analysis b/c it's the most conservative.




 +1 
submitted by jgraham3(13),

https://slideplayer.com/slide/5957557/

The first slide




 +0 
submitted by mousie(210),
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anC onsmoee peeals aexplin tshi ot e?m I ondt' rsuadedntn hwy rgttansi teh orteh durg loduw not tounc sa sieclouxn ?carritei

seagull  This has to do with Intention-to-treat analysis. Essentially, when participants are non-adherent but the data shouldn't be lost. They just undergo another statistical model to account for their changes. Here is a nice video https://www.youtube.com/watch?v=Kps3VzbykFQ&t=7s +18  
dr.xx  Where does the question mention "intention-to-treat"? +  
notadoctor  They seem to be pretty obsessed with "intention-to-treat" it's been asked in one way or another in all the new NBMEs that I've done. (Haven't done 24 as yet) +8  
wutuwantbruv  They don't, intention-to-treat is just the best way to go about it @dr.xx +  
smc213  Great for ITT: https://www.youtube.com/watch?v=Kps3VzbykFQ +4  
yex  I agree with @notadoctor !! +  
ergogenic22  i think if it were per protocol, both groups would be excluded, the ones that were inconsistent, the ones that dropped out, and the ones that switched. But answer choices only allow ITT or exclusion of one group. +  



 +0 
submitted by avicenna(2),

I didn't think much on this question for me the key was the word random- HTN pts were randomly given A or B medication. Don't know which so if people in the study leave or dont take medicine. I dont care. I am including all random data regardless!