The patient exhibits memory loss and cognitive impairment with gradual onset. Alzheimer's disease is likely. Acetylcholine activity is down in Alzheimer's, so ACh-esterase inhibitors are used to make ACh more available, stopping some of the effects of Alzheimer's. Donepezil is an ACh-esterase inhibitor.
A) Co-Q- a factor in mitochondrial OxPhos, it is also an antioxidant. It is used as a dietary supplement, and is not FDA approed for the treatment of anything. C) Riluzole- a glutamate antagonist used to prevent excitotoxicity in ALS patients. D) Selegiline- Selective MAO-B inhibitor that may be used in the treatment of Parkinson's, although I believe other treatments are preferred these days. E) Zinc- important cofactor in many reactions including transcription factors (zinc fingers) and in wound healing.
submitted by โsajaqua1(607)
The patient exhibits memory loss and cognitive impairment with gradual onset. Alzheimer's disease is likely. Acetylcholine activity is down in Alzheimer's, so ACh-esterase inhibitors are used to make ACh more available, stopping some of the effects of Alzheimer's. Donepezil is an ACh-esterase inhibitor.
https://www.drugbank.ca/drugs/DB00843
A) Co-Q- a factor in mitochondrial OxPhos, it is also an antioxidant. It is used as a dietary supplement, and is not FDA approed for the treatment of anything. C) Riluzole- a glutamate antagonist used to prevent excitotoxicity in ALS patients. D) Selegiline- Selective MAO-B inhibitor that may be used in the treatment of Parkinson's, although I believe other treatments are preferred these days. E) Zinc- important cofactor in many reactions including transcription factors (zinc fingers) and in wound healing.