,So rfo eosm sn,orea stenriuotrmtnasre is ismghnote vI'e AWLYSA glrgdsteu h..iwt. barpylbo busacee I a'nswt atghtu it wlel os evrne rlyeal ederlan i,t jtsu edreanl ognhue rfo whvtraee xmae. I tusj onfdu this obo hhuorgt IBCN dan its ASTT!FNICA tIs' from 0102 os thigm be ,old ubt ti asw g.tear uoY cna erasch ughthro het okbo dan idnf hte chps.etar I erptty hcmu just twne hrohugt all of eht setrteionanurrtm pr.thaec nc1hww:w9vob..bopnnm/oKsh.0Ni/9/sk7l.ttigB//

yM nmia :aaksuetaaetwamy-lGt = maorj rittoecyax truoritta.nrmsnee oTw setpy of pset) rr:1eoc peo,iaotbrctm tosm of chiwh rae ianpypercst iG chwhi selad to rseddeeca DANM erporcet itcyavti nda risk fo icicyttit,oxeixo or stocaypisnpt qG rteeopcsr atth eadl to esrnieca +,Na K+, dan dsrcdeeae tautagelm aussce ieipnloatrdaoz adn acednesir +g+M napmcsledeit adn MDNA rrtceope avyticit and kisr fo txocxyiottecii, adn 2) orpiconiot ecnsnlha ingldincu MAND nad taMeak/PAnAi ce,nsnhal ihwhc all lwlao fsiicecopnn cinoat i,nfxul tbu only MDNA lsolwa +aC+ infuxl d(an yonl ni a ovlaegt denedentp narnem efrat iuffsctien izrdaooltianep ahs eclpadisd the iintrbiho +g+M ino ni the anceh.)nl

AGAB dan lincegy = iybtiiohnr oist.ntreatreusrmn ) 1 AAG-BA nad AA-BGC = nrpoticioo nchnsela that lead to uxfle fo ,lC- nda ditpese hsti naiscgu land,epaooirtzi the nrnuoe lislt atsys wobel enirgst t.aionltep AAABG- bniidgn itse ofr tsrba,iautrbe i,sotrdse A,GBA and torpocnixi = deinis oerp fo ahnnecl. -BAAAG binidgn tise fo sodznebaipiznee = iseodtu of opre of nae.lhcn )2 lnGycie ennchal is a evyr limsari -lC fulex he.nalcn 3) BBA-AG si a ottibporcmae nenalch taht tiactasev Gi iedlgan ot aedeserdc APcM hwhci vttcaaise ffuxle +K lacnshne dna biintsih ++Ca ufinlx nhlnaecs naledgi to ieathyp.ioaonzrrpl

ineoBgci neimas = mtanoaseihclec idneompa ord(intocanio fo boyd nmtm,eveo ed,rraw niiamvto,to iecrmrfn,)teone rnnrpenhoepiie e(l,sep sn,auwslfeke natotenti, egifedn bra,ioevh ipphneriene ts(oelw eioannoctctrn ni NC)S, ulsp notoserin sepl(e, nealu,wfekss disnreose,p i,nayxet usa)aen dna sntamieih slro,aua( ointe,antt yalrelg, eustis ma,dage and aym elnicfenu dloob bnria lfow). vobOyslu,i all fo tish si in adniotid ot deringreac stsmnernoinoaiurs and liht,fg rhtfgi, dna tfihg one.srpes

PTA adn roteh rnesipu = icoyatrxte sions,rtanism eerldceosa- with oreth mluomlelcsl-ea rstenituormtrnes.a Aendsonei sin't alysccllais rdeoniecsd a aurrmrtenoisettn aseecbu ti tsin' sldroerea/sedet in C++a ndeetdpen mnen,ra ubt idevedr rofm PAT robeef nivhga an yieacrxott litpnoa.te

Aenhielltcocy = ojamr enttrrutesrmniao iodvelvn in nonsuimosasntrire avi anmsuicr dna ciiicotnn pree.ctsro

tdepPie rtntsurasometneir = onocmyml arlsedee sa ppeerpdoit rgarle rpsurrsoce ttha rae edavlce yb iecpsifc nymseez hatt erwe in the meas rnnamertsriettou vcisele noup eeas.rle ievF setyp = g/artbiun p,tdesiep dpoioi te,epsdpi tipirutya ,epitsdp clihhyaomtpa lrneeaisg enrshmo,o and seoth nto afldei.iscs pslaxEme = srorcrupe htat igvse eirs to nusbascet P scp,uphmipo(a eneoctrox, nda ITG adn eelaedsr ofmr lalsm eitamred SPN C febsri thta mitrants pian and taermrpteue itanonim,ofr fueowrlp hyntopesive, tinidheib by iidoop )dit,ppese ienruknion ,A epetoiudprne ,K adn einppdtereuo mmaga, and diopio dstppeie iuincndgl tlapn isoakldal lkei( )meoirnh,p hyseicttn piodoi drvtis,ivaee nda n,dephsoirn nipsdyrn,oh and iahnpesenlk. nI angelre idioop espipdet are rseentsapsd e.(.i aalisgean ),nmimaecsh vvenldoi ni lpxecmo oaheisbrv sae(xlu raoctin,tta mesgvbvsuesigirss/aei v,ai)osbhre nda ildtmiacpe hg(thou nto evit)ndeiif ni stapicihycr .issreddor

O,rlavle osetmrtritrunesan = tpye :pytes aelme-usolmcll tsaemrrntsti dan ti,supnpeeroed hwere lslulsela-ocmme tnetrtsriams era rafste dna mtaiede rpaid ypcsnita asmrsnnistoi (.e.i edarognn SSN tifgggt/frtfihh/ilh ickuq essr,o)pne rhewe as eproenptdiesu (ganol hwti ioolibcg saiemn dan msoe lalms meclleuo )rttstmarensi era rsoelw adn eeimtad ugraa,ld roegpdlno sumrtnanr.oessiion

moSe sp:rctuie :mr/eteinrvo/abth_tkpwolrdvanaceuuhpeueesidettrw/o_nnum.mk/wd/sseiop.fipt.r_th, l1aeie/4sedb/r/-rBrnbnefd2/o0-iis8rorledffp10haglpiccew1B0Tgd.3Pot-o53ctetu3uwpcwas2-Ag-husaa.a1hRs46irt-pte81/et0-m7sr6a9bg6br6i/-2anr/eg:fp0Ge3A4, and amrd&://-a5pugnellbis.1ad/t;0b813p63wwr-fgsx-/wxf6-d9hdletgtswf.=e5a-.01-t=ataaee1bneic42e7/rgelbhh-e#/ioUg2-idnf_ba

hToug .qustnoei

Rleacl hatt meinaMnte hrsei'zlm(ae ru)dg is a NADM ptrceoeR tonnAagsti taht lphse epertnv tciytexoxiotc by oBgcklin a+C2 tnrye. 'hsTta how I eebrmmre thi.s

• )A AA-BGA pestrceor etl l-C in
• )B lyinceG si esdu ni teh apsiln cord sa an tybniihori r;usrittnreeotnam also slte lC- ni
• C and E) paicMbtretoo atulgtmae presrocet rea otG-prien clpoeud
• rrTeofehe, het yonl hignt that odluc let 2+aC in si DNMA retprsoce

MAND rpectsero ni thsi esac rae iebng sued rof glon rmet ttnponteoiia ithwin het narbi nad out fo lla of ethre ceiosch nlyo sthi oprretec sseu aC+

uoY anc swaren yb ecspros fo eanotn.iilmi tiCiv"petemo ioetnicnt"sra ekmas yuo nthik utmalrystoi N.T sorCs otu BGAA nda eilcgn.y In teh ceoxrt os elt.gmaatu eoicabrtMtpo udolw mane 'tsehre secdon esmsseenrg inevvdol adn the orrtepce wolud otn trtisanm a.cmiucl ceeHn DM.NA

ueds in nlog remt otinteontpia ul,g(angea ommr,ey) aMy alos alpy a lroe in gnee cpitinrasnotr in nrosuen

1) ANDM si a atltauemG roteecrp e2bp )ytus MPAA is a byputes of AMDN ttah si tlyalniii adctaevti by aeulmatgt e le3)easr DANM eposterrc are dfonu anre MAAP peseorcrt but aer ont tcedvatai by wol evlsle fo eatglatmu lseeera edu to a Mg nio ‘knl’igcob teh c anelhn4) etrnueqF Atinoc itetponla g&—t; miitasoltnu fo PAMA ;>— deiaslzrpeo tsop atnpcysi nureno ;g—&t ltveoag tnedepnde Mg lkcbo fo DANM eorcrpet edoevrm 5) flnxiu fo aC hrhuogt ADNM ;t&—g eussca eevn meor APAM cotpserer ot be rtnieesd tnio hte bnmaeemr N:(EOT MPAA si opiverssen to aC nda a)6ae)mlutgt cBuesea ehter are roem rcetrsepo to serndpo to ,ti eth clle is rmeo onipesvres ot guatlmeta

lal the retsoh a tnpmootvcieein sicne yhte hvae sccpf(cicitypfiiesie iln)sa,dg MDNA is het noly ohecnve(enieltescn pitocmeetiv o,ercrpte) sha a anidgl stei dan ac , an nad .hn.g.eemc ipeitvcoemt