oS, rof moes nr,oaes nearmorstuiestnrt is sghmoenit ev'I LWYAAS tegdrgsul h..iw.t ralpybob eabcsue I w'tnas hatgut it lwel so renve ralley enelrad i,t utjs laerden enguho ofr veaehrtw ae.xm I sujt ndofu hsit boo uhrtgho NICB and sit AITSC!NTAF tIs' ofmr 0201 os gihmt be l,do utb ti aws e.artg uoY can echsar touhgrh teh obko nad dnif hte c.hatsrpe I yptter hcum juts tnwe tghruoh all fo hte smrtnanrteoiuert ra.ephtc bb.otpi9h/gsk./nioB9nw7t1/wnl/hs.c/:wvomK0.N

yM iman yeaa:Gsatlmawe-uktta = jrmao tcaxyreiot utr.sinrttnremaeo Two teyps of )rorc1pt:ees tepcboi,rtoma sotm fo hihwc rae scntpaieyrp Gi hchiw lades ot deeasecrd NDAM eecorprt ivtaityc dan sirk of xiityoictcie,txo ro ptyopntcssai qG tscrepero taht edal ot nseecria ,N+a +K, dan eddrcesea eagmlattu uacsse tapleozordiian nda eandercsi +g+M dtemipsclaen adn DNMA otrepcer itiatcvy dna iksr fo tcxeixcttiyoio, adn 2 ) ooticnrpoi senncahl udniingcl ANDM adn AknteM/aaPiA nnhclase, hwich lal oawll ioscncfiepn noatci iu,xfln ubt ylon ADNM wsaoll C++a iuflxn (nad ynlo in a gotavle dndteeenp annerm ftare cunftesifi draioopieztaln hsa eadslpdci het noibhtiri M+g+ oni ni the lhc.na)ne

BAGA nad lynigce = itbohniiyr rotinsurme.ttarsen 1) AB-GAA and CA-BAG = otporionci chnnslea taht leda ot lexuf of ,-Cl and teidesp shti sauincg oi,nitroeaapldz hte nruneo tslli syats beowl igsnter naoiel.ptt AAB-AG ingibnd tise fro utbsatibearr, dte,osisr BGA,A dna oproxniitc = dineis epor of nl.cenha AGBAA- bningdi tsie fo baziiepzosenedn = tsodiue of peor of eanlhnc. 2) lineycG eclhnan is a yvre maisilr -lC elfxu nen.lhca 3 ) BAAGB- si a itcmbptaoore nehcaln tath tstavecia iG nelgdia to deaecserd MPAc hhwic etaaiscvt efxulf K+ sncaelnh nda shtiniib +Ca+ fixnul slenncah gndliea ot zy.inohrppiaaetrlo

igincBoe mseani = eshmiaclectnoa admnioep tcooonindir(a of obyd eot,vemnm eardwr, i,aoointtvm mtenio,nfece)rr ennrprehieonpi epel(s, efasknwluse, nat,ointet fengdie hve,obria nriiehpeenp eost(lw trointcacnone ni SCN,) upsl nneiorsot e(l,pes uflanek,esws osnp,disere yxeiat,n n)uaase nda imienstha ar,oalu(s ,itntaento g,ralyel suitse agad,me adn yam uenncfeil oblod ibarn .of)lw iyvsO,oulb all fo isht is ni didiotna ot cedngerair nrstmioanorissenu and lhg,tif ,fright dna htigf ee.ssopnr

PAT nad ehrto esprnui = iacreoxytt ianr,smonsist scede-raoel hitw hreot uemlll-elsaocm irmnsstarotertun.e oeesnnAdi 'ints asllysalcci cienrdsode a ruesmernirtttoan scuebae it t'ins eaor/teeesdsdlr in +C+a nntepeded ena,nmr tbu dedvrei rmfo ATP feerob ahving an oayirtxect olaetipt.n

oeAlylnhtcice = moraj rieuttrerosntnam dovivlne ni runnnsoertssamiio avi irumnsca dan oitinncic rsotpeecr.

Pieptde tersniuasoerntrmt = ncolmoym aelreeds as etiodpprep glraer pocrserurs hatt ear eadcvel yb eicfpcsi mynesze that erwe ni het maes uerroserntatmnit vceslei uonp eseae.lr veiF yetps = nug/airbt pstipeed, iipood edp,piets ptutyiair pi,dpste ilphoachaytm ranieelsg rn,msheoo dna soeth ton cfi.sisdael laxpEmes = puecrrros atth gsvei eisr to cbuetasns P pi(usmahpo,cp etconxo,re nda TGI nda easerled mofr mllsa aeidetmr SNP C rsbeif hatt tamrinst apin dan rumetpeaetr aoirfniotm,n wrfepoul noheetsyp,vi iebindtih by oiodip dt,e)isppe oeukirninn ,A pioetprundee K, dna puerneoptdie magam, nad ipodoi ppdeeits cigidnnlu platn oaliksdal ei(kl ehi,nmr)po htnieysct ipdioo diravts,ieev dan hindnoper,s dnryhino,ps adn .haelkiesnpn In eeglnra iipodo iedptspe are tednraespss .ei(. aiaslaneg mms,)niheca livovden in mcplxoe vsbiaerho el(usax ,irctattnao ugesrimsvsbee/sisgiav ovi)bae,hrs dna iplmaticde ohutgh( otn idte)nviefi ni piicshrcayt eod.dsrsri

llae,vrO mrisnnertttseraou = pety pt:sye saloeuclemlml- irrnssemattt dna erntoduep,esip eewhr -csmsolllalemue naristemsttr are serfat adn tieedma aridp caytnpsi snisansoitrm e..i( goraennd SNS hgghfgrht//ittiiffl iuqkc s,e)sprneo whree sa epeopdinsteru n(galo twih bgioocil aiensm nda omes lsalm melelcou ms)tnritesart rea rwseol dna emitade ld,graau orngdolep ssonareoiir.numnst

meSo i:tcpsuer drmmorha_twtepv.olsfcptueuwtd.i.hnusodke_tprrenthsepee/arebi:umn/vi/w_/kan/toi, p3thf/73e-rrtd-ncgr6eBsArabl3ogici/afoe.e4a2.s0tlspP45R4dfo/61ai1n23u6rrspu82r//eec:gt1/-w9h60a/-otp-1-rfbu8eTde0gasdeeGbsargc0m1l-A-itbp0awnieihwB, nda gfeltie#t-fsuf0toUgsae=50bb=1/ra6ep53b/dwfd;_n1b6d4wel/cd/ia7&nelli1arhap/rbmntx.-edesx2wg8h-ah--.a3g.:a1i-t-/e2-g9w

ohTug utineqs.o

lRcale htta aMtmnenie azer('ilhsem drg)u is a MNDA Rrteocpe tiotnsangA thta selph evrenpt tcxcittxiyeoo yb cgoBlkni +2Ca tnery. astTh' owh I mrmeeerb iht.s

• )A GAA-AB tpeorscre elt -Cl in
• B) nGiyelc si used ni hte alipns rcdo sa na btnroiyihi uottnrmreiretan;s lsao tels Cl- in
• C adn E) brtMapotoeic tlamgaetu csperreto rea p-reitGon edlcuop
• ,Toreerhef het lnoy tngih atth colud let 2a+C ni si DANM ercporets

MDAN rtepoercs ni siht scae are gnbei euds for olng mret onoenpttaiit thwiin teh iarnb adn uto fo lla fo rhete hsoceci yoln sith oepertcr ssue Ca+

ouY acn nwares yb oprcess of iatoe.linnim itCevimpt"eo snonct"etraii emsak you ikhnt rtilmuystao N.T ssCro out ABAG dna yce.lgin In teh otcrxe os .umgltatea ciMebootptar dulwo nema ehre'ts eoscnd rnmegseess ovilvedn nda the roecpetr lowdu nto irtsmtna mci.lcau eecnH A.MND

usde ni lnog rmet onittoietnpa g(uleg,ana emro)ym, yMa lsoa layp a reol in neeg rtintnpasicro in ounnser

1) AMND is a lmattaGue roeptrec s2upyeb )t MAAP is a eubtpys of NDAM taht is yiiitlanl aaditvect yb atmutaelg lereea)3s DANM oeerctrps aer oufdn nare AAMP cpseorrte utb rae not dteacvtia yb wol eelvls of gultataem relesae due ot a gM ion nb‘lck’ogi teh en )hcna4l qeertnuF coniAt iptlaoten ;t—&g soniutamlit fo AAPM —&;gt ladrozeeips post capynsit onnure &g—t; vtgaole denpeetdn gM bclok of MDAN ertpceor evoremd 5) fnxliu of Ca tgrouhh ADNM —tg&; aucess nvee roem MAAP opreersct ot eb estinder iont hte rmbeenam TON(:E PAMA is snspoeievr to aC adn tm lt)6uaae)g ecasuBe terhe rea eomr tecosprer to sopernd to ,ti eht clel si roem esnvripseo ot ttaelumag

lal eht hseotr a mecoiinvntteop seicn teyh eahv ctfsecciippyfice(isi sidga,l)n DMAN si teh ynlo eehoeiesvnec(nctnl pttcimoivee )eerto,pcr ahs a naldgi stei nad ca , na dan m..nceeg.h teitcvoeipm