,So for seom o,nesar rtorsunnrtieseamt is mgsheinot 'Ive WAYLAS lgtusrdge i.h..tw rboyplab eaucebs I an'tsw atught ti ellw so evern aleylr adereln ti, sjtu nleerda hguone rfo raheewtv exma. I tujs udonf ihst oob troguhh BICN and tsi TTSCIAAF!N 'Its from 2010 os tighm eb ol,d btu it aws are.tg ouY acn creash huhgtro the okob nda find het stca.pher I ypttre mchu sjtu wetn htorhgu lal of the iemrarnutoetstnr ceh.trap c0o9t1iw9NsBh.7kpgwiolK/.onvhn/.btn//:w.s/mb

yM iamn saaGl kwat-etaya:muet = raojm ytxaecrtoi .rtnsaomtreunreti wTo eytps fo )r:tsopre1ce oeat,rbicomtp tmos of iwhhc rea anerypipcst Gi hhwci ldeas to derseaedc ADMN reoceprt tayivtic dan iskr of tixyciit,toieocx ro isapsyptcton Gq oesrpertc ttah alde to rnicseae +a,N +,K dan eerscdeda algmuetat cessua pzaatenrdiolio dna aicndrees ++Mg mtlaedpensic nda AMND peerotcr tiyitavc adn rsik of itoxicte,ityocx dna 2) oocirpnito nhsaelcn ucgidnnli MDAN nad kAMAPiaaet/n anhlces,n ciwhh lla lwalo ensnpicciof nioatc n,xfuli ubt yonl NAMD laolsw +C+a lxnifu d(na oyln in a toaevlg neednetpd nmnear areft ensiufftci ordnteaiaizlpo sah disleapdc eht ntobiriih M++g ion in the .hncean)l

GAAB dna ingyecl = iiyhbointr tiartnmntr.eussroe )1 ABGAA- adn AA-GCB = ooioitrpcn eslahncn hatt dale to fulxe of l-C, nda dpiseet itsh gcnsaui niizrt,edaoploa hte nnroeu isltl ssyta wlboe nsegrit paettil.no AAGB-A gdbnini seti rof ar,bettrbaius rst,osedi ABAG, and ioptconirx = isendi oepr fo cn.laehn AGABA- ginbndi tsei of saezidionenbezp = tueiosd fo epor fo annlce.h )2 iynecGl leacnhn si a revy imlairs lC- leuxf .hnealcn )3 GAABB- is a apcimbetroto helancn atht itvsectaa iG dgelnai to asedreced PMAc ihhcw etstacvia uxelff +K scnaehln dan snibihti +aC+ xlfniu ahesnncl ilegnda ot yhpzrite.liapraoon

gicnBeoi sanmie = seanehlamciotc miadpone icdintoar(ono fo oydb tvem,mneo w,reard iaitno,motv )ieemnofcretn,r epirphnoernein ls(ee,p sskfneluw,ea tetnan,tio eindfge ib,ehvora reeenippihn s(tlowe oearnitcctnon in CN,)S splu oersionnt se,pe(l neasfwsuel,k oie,rpsdnse ,eiatynx asnu)ae dan esnmtiaih a,url(osa ntioe,tatn ,leyagrl ieutss edg,ama dna mya uelifcnen olodb ibarn l.)fwo lviybsou,O lal of htis is in daoiindt to regcinreda smouantnisrornsei dan tlf,hgi ,hiftrg dna gitfh e.srspoen

APT adn tehor ernsipu = yaecitroxt tosinam,ssinr ed-oasclere tihw hoert laoesluecml-ml rnessrumttnioet.ar Aesonedin 'ntis cslalscyali oncriddese a treaenritsunormt cuaebse it is'tn ertsdsedoale/er in +C+a ndeeptden nme,nar but ddvreei rfmo ATP obreef hvgian na ceyaxttori l.aitptoen

hAeocilcelnty = ojmar isttmatuerernron vedivlon ni mnrentsaiirsoonus vai muacsnir and nccniitio rcpsee.otr

ideptPe rtsntmeneutrasroi = lycmmono edelersa as tppeiodrep ergral resrpucros hatt aer daelevc yb piicsfce meyesnz htat weer ni hte asme teiusrttnrnramoe ieeclsv oupn aselere. eFiv spety = bgin/trua dpeetp,is oipdio pdps,teei truiiyapt ptepsd,i ohhaicaltmpy argslniee somh,oren nda otseh nto .deaicfssil xEepmasl = prerocrsu thta sgive esir to anuctebss P mc(piah,pposu otreoc,xne and ITG adn drlesaee morf mllsa idemrtea NSP C fersbi htat imtrstna ipna dan uaerperttem ranmoitf,nio ufwpeolr es,ytenvphoi iithbneid yb oidpio deseipp,t) iunenonirk ,A tronuieppede ,K nda rotuieeneppd gm,ama nad opdioi dtesppei iclngndui lpant iasodklla i(ekl mohpenir), yhscteitn opdoii vsevaiei,trd nad ,eonpndhsri n,sdhipoyrn adn kelnnasip.he In aegelnr opiodi epdiespt ear sdtrssepena (.e.i agilsnaae smh)imecan, dnevlovi ni cxmelpo eibrhavos saul(xe t,critntaao brsivssgasmisugeeiv/e sihaeo),brv dan imtleicpda ohh(gut otn d)tieenivfi in yciahcsrpti esro.ddsir

raOe,llv nsotrtestiuanrmer = type psyte: omllcml-esuale rttsmniresat dan esrtinepoepd,u erewh suae-lemsomclll tmsrtsianetr era rfseat nad teediam pirad synaitpc misnntsioasr (i.e. nrdgonae SNS hi/fhglttrf/tggiifh qikuc nsre)s,peo reweh sa steieurendppo lgoan( hitw oobciigl nsaeim adn meso lmlsa leceumol ne)rtittarsms ear relosw nda etaeimd luaadrg, gdrooepnl srtsuroanesio.innm

moSe e:isptcur hw_rwkei.ee_ia/tehefknwusoo/up/ioae.t/tuanp.d/isvdecmmlrsot:unppebtvttmdr_rhrn, uptdao//-sdr0o2orsdh0r4tst.h73raeg1seGaptu/i0c-w6e89lee/1te-Pre31pb3g3rat6h6rpb:f2-Bgi/c651a/Aw/fRfpbT-g0ars.uimn-4-1o2-rdcn48flingeaAwsbleeia0iecB, nad ec/tlal-ahanng0e1rsxewb5x=&:wh=/3-/8/-13l.2oei6b-u.ih/tagfwif-;gsdfrdbsamdfe#t119.-5e/a-bt0gpdapild-e4ng_t6Uee7a2wrb

Tghou ouiqest.n

celRal hatt taMemnein zehiea'rl(ms )drug is a NADM prRteeoc stignnoAta atht seplh reepvnt oceoixittctxy by giklBocn +2Ca yntre. sha'Tt woh I mbeeremr ts.hi

• A) A-BAAG ertoesprc etl C-l in
• B) icGlyen is esdu in het ialnsp rodc as na hbiyriotin nrmieroruet;nttas loas estl l-C ni
• C nda )E abottpMcrioe uemlgatta tcrproese are iGrenpot- lpeduoc
• reT,eerhfo eth oyln ignth ahtt odclu tel 2Ca+ in si ADMN prcotrees

DNMA cesorpetr ni sith seca rae ibnge sdue ofr onlg trme paotnotntiei htiinw the brnia nad uot of all fo eerht ioccshe noly tsih petrocer sesu Ca+

uoY anc wsraen yb sprsoce fo min.lnietoia mie"vpttoeCi ea"trnitcsoni ekams yuo hiktn sutirmtaloy TN. rsCso uot ABGA nda inlge.cy nI teh croext so tlteugm.aa etoiMacbprto uowdl eman he'stre senodc ssemersegn dlnvvieo nda het teocerpr dluwo tno rimstnta cclim.ua eenHc AN.MD

udse in nlgo trem etoaitnption naegl(u,ga omr,my)e yMa osal apyl a eolr ni enge tanpotnrcrisi ni usnorne

)1 ANMD si a aeGttlaum etoeprcr yetp2u)b s PMAA is a ytsubpe of DMNA taht si iylitlina acadettvi by telatumga e3r )eslae NDAM rcotseper era noudf near APAM rpceroest but rea tno ativdteac yb owl levsle of luattmeag seeeral ued to a gM nio bgilonck’‘ eth )n e4hlcna nruetFeq Aitonc ptnaliote &g;t— umslnitatio of APAM &;—tg lpzeisadreo otps sptyinac ornenu ;t&—g oaglevt pedtnnede gM koblc of DNMA poecrret remvoed 5 ) unlxif of Ca htogrhu MNDA tg&;— caseus neev rmoe APMA erpscreto to eb sieetndr otin eth aemnembr NOE(:T AMAP is rspvnieose to Ca dna a6tm)u) laget eeasuBc reeht aer orem prtseeocr ot roesndp ot ti, teh llce si emor sveeirnspo to geataltmu

lal het stroeh a tiemcovnponeit insce yeth evha piycieiftfcspi(cseci ,a)ldgnis NDAM si teh lony enhieoeenlcecn(vts iemiptocvte )pretr,oce has a dlngia tsie nda ac , na nda .egn..emhc viimtecoept