effect of glutamate antagonist on pt with acute cerebral infarction = targets NMDA receptor
decreases calcium entry into neurons = decreased excitotoxicity = promotes recovery from acute cerebral infarction.
Tguoh nqous.eit
elclaR that iameMnnte re(m'elaszhi ug)rd si a AMND treRpoec otAinstgan ttha plhes tpvrnee oteicicytxtox by nkcolgBi a2+C erytn. 'htasT hwo I rermmbee .ihts
a picture for better understanding https://2e.mindsmachine.com/asf04.02.html
^ link is dead :( (they published a 3/e) but here is the re-route to the new site if anyone wants to dig in https://learninglink.oup.com/access/watson3e-student-resources
AMDN rpscoeret in sith ceas rae gbien desu fro lgon mter ionntteoapti wtinih hte barin and tuo of lla fo rhete ocsiceh ynol tish oceterpr essu Ca+
I pidcke MDNA ubecesa s’it iruy,mtltsoa tbu si there yna edeepr renoas fro thsi?
You nca ernaws yb ecrspos of mintnlioe.ia it"oieCpvetm ttncaii"ensor eksam you kihnt outirtlsyma N.T Csrso otu AGBA nad legiy.cn In eht ocxter os l.tgaaeutm oaMtpterbcoi dluow eamn shet'er enocds nemgeesrss nolvevdi dan teh rterceop uowdl ont ntramist lacci.mu eHnec MD.NA
dues in olgn rmte npaeoitiottn aau(g,lgne ye)rmm,o Mya saol lyap a oerl ni ngee tirsnacnrotpi in nsnuoer
)1 NAMD si a melGataut teoceprr )tbus2eyp MPAA si a bestpyu fo AMDN atth is iyaiitlln vttdaicae by taumelgat ersl3 )aee AMND secortrpe rea udofn rnea AMAP oeesctrpr but are ton adtitacev yb low evlsle fo atetumlga aeeselr ude to a Mg oni gc‘nob’kil eht )c 4nhneal eqFtuern icAtno eoiplatnt g&;t— omatilsnuti fo MAAP gt—;& alrdiopszee tpos ytsnciap ouennr &;—tg alovtge pdetneedn Mg okcbl of DMAN rceetpro merdvoe 5) fxlniu fo aC hghoutr MDAN tg&;— uescas evne moer AMAP oecsperrt to be ierstend niot eth ebemmran EO:(NT PAMA si rseepivnso ot aC adn me)u6al agtt) caBesue etrhe are eomr ortcperse to edspron to it, eht clle si eorm nosrpesevi to taguelamt
lal the tsehro a mnivtieenpotco inces tyeh vahe i(iscfpsctifcpeiycei )ngdli,as NMDA si eth loyn leenon(niesthecvce itcoetmepvi prcrteoe,) ash a gdlina ties and ca , na nda nc.gh.me.e cetoipetvim
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$379$49,So fro moes rane,so nrestutasmorretin si egtnoismh e'vI YSAWLA lgstrgeud i.th.w. oaybbrpl baeusce I nwsa't tatugh it llwe so enerv llyear leenrda ,ti sjut aelendr hgeuon ofr taewrhev mex.a I ujst fdoun itsh obo guothhr INBC nda tis TNAFTS!ICA 'Ist ofmr 1002 so mhtig be o,ld tbu ti asw .agert You nac chsaer othhrug eht koob nad ndif eth e.ahstrpc I tpyter umch just netw rohgthu all fo eth somtteniranurtre htape.rc i1:m/.nhoowvNs.B/n9sgt9Kbo/nw/7lhkt/bw0c..ip
yM mnia matwasaGuttyklae:a -e = amorj tayioretxc urrtian.oeesnmttr Tow ptyse fo ee:r)r s1cotp ,toribmpoceta omts fo hihcw era itrpsyncepa Gi hihcw lesda ot rasdeeedc NDMA treocper iavtytic dna skir fo ttxixy,coiiiceot ro ppionsastcty qG prcsoeret thta dlae to sreecani Na,+ K+, and cdeadseer tueagaltm sascue aelznooirdatip nad isnecdear +g+M epcelmtdiasn dna NADM cpreroet ytivtica nda riks fo toiic,etxycxoti adn 2 ) ootnrcipoi nehnlsca cilundgni ANDM and k/nMtAaAeiPa ,shanecnl hcwhi lal allow icnfecsopin incoat ulix,fn btu oynl DNMA sawlol C++a ulnifx ad(n ylno ni a vgteoal deeptnned mnearn eartf esntiuicff areoiplzdnioat ash iasdlpced hte hotrbiiin Mg++ noi ni eht nlah)ne.c
BGAA nad igecnyl = ntyhiroibi rsarurntioetstne.m )1 -AAAGB dna ABACG- = rpinoootic cnhsnale that eadl to leufx fo lC,- dan dptsiee siht iscunag ,poiaedirnozlat the ronnue stlil ssayt bleow rsgient oe.nltatip -AABGA idnbngi stie ofr tu,rtesbaabri otsr,eids BAAG, and cnoixiport = sidnei oepr of lh.ncean GA-AAB inidgnb seit of aioinsenbepzdze = itdseou fo pore fo nehn.lac 2) eGnyilc nlhecna si a eryv airsiml -lC euxlf hca.lnen ) 3 BBGA-A si a obraocpimtet alennhc htat ciaetsvat Gi niledag ot eecerasdd MPAc hwihc estvatica fxfeul K+ leascnnh dna hbiniits +aC+ nuixfl cnhlensa nldigea ot ltieona.rapohyrizp
ocigeinB naemis = enlchicamtsaoe ndiopeam inniroodoac(t of doby etmnm,ove ed,rawr ,ttmoviinao eoci,nmrnrtee)f pninroiherepen lpse(e, ulfenks,awse toi,tntane edengif bro,vhaei eeepinhnipr (oewtls ncnrocettoani in C,SN) plsu etornosin el,e(sp n,sfawesklue sinoeepsrd, iaytxn,e eusa)an dna seimhnita uslr(o,aa eatontit,n l,argley tseuis mgde,aa nad amy inceelufn odlbo ranib .)wlfo voOu,bisly lla fo sith si in iitnddoa to erdcrgenia ruernaosmsnoistni and hf,igtl gtfrh,i adn htgfi erssoenp.
ATP and rheto snerpiu = icayteoxrt srtiosnmsni,a cels-roeeda ihwt erhto mlaecuse-mloll anesrmotuiste.rrtn eneAindso ti'sn sicaaclylls ndeoreisdc a rureartnnmsetoti cbauees it itns' drsol/teraedese in C+a+ tednpndee nrnaem, tbu dverdie ormf PAT reobef hngvai na xeotartyic npa.etoitl
yeletincloAch = omraj amtiuntrstnreeor onviedlv ni mnnuantirsisroseo iva ruisncam dna oinnciict rere.pscto
epdtiPe ruttntreeamirnoss = ooynmcml erselaed sa depiptreop argrle ssurpcrreo that ear edcalve yb sceifipc sznemey taht rwee in eht msae uramneornteristt clseeiv puno .lreeeas iFve stype = nbguir/ta esp,eptdi doiipo eeisdtpp, iauttpiyr dsppi,et ptyilhaomahc eiagserln h,oemnors dan tshoe otn dscli.safei axEsmpel = rcuesoprr atht gsevi sier ot unbcasste P c(a,oppsihmup ro,ocntexe dan GIT dna reseelda mrfo llsma aerdimet NPS C sibref tath ntsrtmai ainp and uemaertrpet to,iifaonrnm efwroupl eoshtny,pevi tebndihii yb ooipid ,sepit)dep uniiknnore A, edpeputoienr ,K and enuppieretod gamm,a adn poidio etpipsed duiicglnn laptn aodsiklal le(ik r,hnpom)ie ethtnciys idpooi ,etdvsrieiav adn ,srdnepnioh pyn,shiornd and keanheip.lsn nI geenrla dpoioi ideeppts aer esedspsrtan (.ei. asaialeng hmmcsa,ein) vldnvoie in elocpxm rsoeabhvi us(elxa r,ttanacito ruev/siimsveagegsssbi )ebvo,ihars dna mcladiteip og(htuh tno eie)infvidt in rccphitisya d.erdrisos
O,velarl atinrtmssrerounet = ypte :yptse laolsluelmm-ce asiestrnmttr and rppeiudoesen,t eewhr ssmu-lllmeelcoa starietnmstr era aftesr dan miteeda adipr cnstpayi nsssimatiron ei.(. ndnergao SSN /gtr/ihtgighitlffhf kiqcu p,n)sseroe weher as onerpupteides n(olag iwth olgiibco esniam nad omse mllas ueleocml astrnetirtms) rae oewlrs dan eiedamt rd,alaug onedprglo srutnamrsnns.ioieo
omeS tc:eupirs v_ttemwhsnnh/eteirb.rt:hrkkrodnrsceo/sp_t.leiaa/mueutnpiiuedfdm_.v//patoowuewp, pce1o1ih0.-11g6fcugaibbs3-a3f-lwen7i40g0-wroicdAieeRt//-8ehdl:06pstfo-rtrde4nbrT3mfrs9rsePi58auae/Aa2ns-d0aarrbpG3/etp6pa16lBwht-cBog/etu.4s2reg/2/, nda =de9/_tedUl.=f-s/alhlbag-/dtrbr2gfxuwmlhg7t3a2sger-e6bfwt0d--bei.gbdfin3aw/6;.a&10-p-1aice5p1wa/asn1:te45e-oxe/#in8h
$379$49