S,o ofr omse ,sreano aimuoentrtesrrtns si egimhston 'vIe WSYALA gtdgruels ...itwh bpyarobl euaebsc I n'tsaw attguh it lelw so neerv lrelay darenel ,it tsuj raeendl ohegnu orf tehvawre eaxm. I utsj dunof thsi boo ughtorh CBNI adn tis A!TACTFINS ts'I fomr 2001 so mhitg eb ol,d utb ti swa .great uoY cna sachre uhghtor het boko dna idfn teh rehsacpt. I rpytte hcmu sutj ntwe hgotruh lal of the treinmttnurseora chapert. 9vn:mhp/.ioNl/o7K/i.Bntkobtbg/s0.nc1shww/w.9

yM ianm lst-auatGatw eakyeam: = rojma ytatrxeico arrnenetsittm.rou oTw psety fo treo:se1pcr) ,ipemocrtabto otsm fo chiwh rae seinpytprac Gi which dsale to daedserce DANM rcoeeptr aiiycttv nda rksi fo i,ixtoitiotxycec ro tnacsyptiops Gq toesrecrp ttah deal to ceanresi ,N+a +,K adn ederaesdc glmauttea euascs iepladzrantoio dan ernsdicea Mg++ tcapsnlemdie and DNMA toprcree vaiitcty and skri fo iicxecitxtoo,ty nda ) 2 iioctonpor nhseanlc cldnugini AMND nad eA/MnPkAaati ,ahnlesnc hicwh lal olwal peccniosifn ancito nlui,xf btu lnoy DMNA walsol a+C+ xlnifu a(nd olny in a tvegaol epndnedet ennmar afret tsfiiefncu lazeioridtaopn ahs daceipdsl eht ihrioitbn ++gM ion in teh ).celhnna

BGAA nad eylincg = ihytbiorni mat.ttnrsrueonrsei 1) A-BGAA nad -ACBGA = cipntooiro hnenascl ttha elad to fuxle of -,Cl nda pdestie tish csaginu ilazaotnriedp,o teh onneru istll syast loweb itrgsne e.patlotin AA-BGA dibnnig siet rfo irtes,ubrtbaa setodi,rs B,GAA and cotroipinx = nsidie oepr fo nelna.ch BAA-AG bdngnii siet fo ebeazsndopzniie = tsdeoiu of rpoe of nhacne.l )2 eycnilG nleachn is a veyr iamlisr C-l efxlu .nhalecn ) 3 AGBAB- is a irtmopbtoeac nhnelac htta taicevsat Gi dinagel ot decesdera cAMP cwhih secivatat feluxf K+ lhncsean dna htisiinb aC++ nfixul lenhcans eiladng ot zpoyirpnhlatria.eo

oBgicien niames = icmcnaehsaoetl deaponmi irncnoai(doto of ydbo ee,ntmvmo ,drawre mnitio,aovt )ocrn,irneetmef rpiernenponihe esp,(le usl,kenwefas en,atotnti figneed hbevio,ar ireienppenh sotw(el ntronancotcie in SN)C, ulps enrooinst (es,elp saunekwfsel, eioessrnp,d yaxint,e unaas)e dan anismeith (lsaro,au oetn,ittan yl,glrea ueists gaaedm, nad yam eneinulcf lbodo riban .wlof) sbuilv,oyO lla fo sith si in iaiodtnd ot greiedcnra oisnmneisurorsnat nda ,lihftg tgfi,rh and tghfi osp.erens

TAP dna hoetr rseipun = coterxiyta raison,smstni es-laeoercd hitw thero lueslmcelo-mla euiottnmrrsare.snt Anodeiesn ts'in acslslliayc scdneoredi a arirtnonstremute cbesaeu it stin' /esalesrreodetd in a+C+ deepnnedt arnm,en tub viedrde mfro ATP ofbere vaingh na coyatextri .plantoite

tcellhAconeyi = arjom inetrmrtsuatnoer evnlvoid in nmureorisasnsinot iav iucrmnas dan ncnoiitic portes.cre

peetidP otainetsnrtrumsre = coymolmn sdlereae sa tioeerpdpp lrgear osprrcersu ttah rae vealdec yb ecfpsici smezyne tath weer ni hte esam rreneoranttstmiu cieslev uonp lear.ese Feiv setyp = /abrntugi ids,eetpp ooipdi ptspieed, atiyruipt petpsdi, tocyiphhaaml renlseiag hoosenm,r adn otseh tno cdaile.sfis maplxeEs = ucrsorerp that sgive rsie to bucstaesn P m(aposuhci,pp o,enecrxot and ITG adn dslreeea mrof mlasl imtdaree SPN C befrsi thta tmnsiatr npai dan reetpumerta o,noiniftamr lreufopw ehevint,ypso tbidihein yb pidioo e)d,etpsip ieunonrnki ,A eirpneetoudp ,K dan eioepptrednu ,amagm nda piiood psepidet idncunilg natlp ilaldkosa i(kle ieoh)mnr,p ytteishnc dipooi tvidsveaei,r nda ,hdosnrenip nhrspd,oiny dna ksealniehp.n nI ngreeal dpioio peetsdip rea ptseaerdssn (e..i liagnaaes mie)hcsm,na devnilov ni ocmelxp esaborhiv l(xaues tointtr,aac ie/uirbevsgesamssgivs ,oriabhesv) nad iitmeladpc gu(hoth otn tfiien)dive in ctsapirycih ds.deorris

ralvO,el rnaretenmutirtsso = ptey syp:et -leleollmmasuc rsntatirtsme dna peornse,ediutp hreew lualomecelsmsl- ttesmastrrni rae ertfas dan etmaied irpad ctiapysn ioansrtimnss i(..e ngdnaeor NSS tifggtf/tlgihhrih/f uikcq r)npoe,sse eehrw as oiednerppestu lg(nao ihtw liiocbgo smeina nda semo llsam eollecmu ie)rtttsmsnar ear olresw nad aitmede agu,alrd goledrpno .untssmnroeioansir

oeSm iu:retspc hee_/autvlum.csemre//pnrekrtppiahte_tiws:e/iwut/tn.ndosefodrhndotawkvobpur_im., tc8:/-a1egraf0841g43-gfpehef-su1oPaed--22rs-ahbes/uttdlobeb13mul.rswg.ba/e/wctpBpri9ri6h05i-d036lp/aGfpA6stga0Rnr2tar01seriw7A6dc4nio/enroB-3Te/eic, and h/-f6e/bcx1wi/-16gw-1.l0r-li7s2x0ee-p5e=fnptf_de.=.a3rlb5imdUb/1aewab&-ob8ggt2:s4wuht-;nf/edie/9ddrt3aaglageht-asa#n

gohuT i.eqoutns

lRleca tath tmeennMai rmzlei'ah(es rg)ud is a NAMD peoercRt insotngAat ttah lepsh eerpnvt ecitctioxtxyo by Bcnikgol aC+2 tenyr. 'Tahts woh I ebmrmeer st.ih

• A) AG-AAB eotcepsrr let Cl- ni
• )B leycinG si usde in teh pnails rcod as an tynhiirbio oantrttrmuriense; olsa tels l-C ni
• C adn )E ebpcoirattMo aulgttaem tseorerpc aer Georip-nt deculop
• orrTf,heee eht oyln nghti thta ulcdo tel a+2C ni si MNDA erpcostre

MDAN rscrpoete in hist seac rea ebnig eusd for nogl mret oanoitetnpti hntiwi the nriba and tuo fo lal fo ereht hscicoe lnoy htsi ecropetr sesu a+C

uoY nca anersw yb esrsopc of ianiom.nitle iCem"iottepv "iescrttoinan akmse you inkht uyottlasrim .NT Cross tuo BGAA adn yngl.iec In hte xteocr so taultegma. etbtcaoriopM uoldw nmea etr'esh encdso reegsesmns ivvloden and het reetropc ouwdl ton snrattmi cuam.lic neecH MNA.D

euds in nlog trme oeaiotnttpin ,negugl(aa ,o)rymme ayM soal aply a lroe ni gene soianrrptcnit ni oeursnn

)1 NDAM si a taatumlGe oretcpre st)u2bp ey AMPA is a btepsuy of MNAD taht si nlyiilati avateticd yb luemttaga sl3eere)a NDMA rtorespce rea ndfou aner AMPA seerotcrp utb era nto etdatacvi yb lwo velsle fo uemgaattl alreese deu to a gM nio obn’ckgli‘ eth la nh)en4c uqenFret Acntio tiptaelon &g—t; uaiimlttosn of MAAP &—g;t lzropdaisee stop itcnapys urnoen &—gt; eogatlv ntedendpe Mg cbkol of DNAM errpcteo eoevdmr 5) uxnlfi fo aC houhtrg ADNM —g&;t seasuc eenv mero PMAA psoreetrc to eb etdersni tnoi the embaenmr ONE:T( PMAA si esionrepsv ot aC dna )etl) at6uamg eueaBcs ether rae ermo etcorrsep to pnodres ot i,t teh clel is rmoe reesnvoisp to atgmetual

all hte restho a niocttmniepove csnei htye evha yipiicceicssiec(pftf )gsaln,di ANDM si eht lnyo evte(ecsehinnnoecl eipeomtvitc rrc,)etoep sha a iagldn iest dna ca , na dan .e..ngmceh ieoitcvptem