effect of glutamate antagonist on pt with acute cerebral infarction = targets NMDA receptor
decreases calcium entry into neurons = decreased excitotoxicity = promotes recovery from acute cerebral infarction.
Toghu esnqu.ito
Rclale atth mMntaenei reil'sam(ezh )ugdr is a MNDA Rrtcepoe oAnstgntai thta hlesp epnterv xctxciiytotoe by Bcoikgnl 2Ca+ tryne. 'hsaTt ohw I eemmberr tihs.
a picture for better understanding https://2e.mindsmachine.com/asf04.02.html
^ link is dead :( (they published a 3/e) but here is the re-route to the new site if anyone wants to dig in https://learninglink.oup.com/access/watson3e-student-resources
NMDA creproets in isht caes rae igenb duse ofr nglo emrt annoietoptti iihnwt the irabn dna out fo all of rthee shicoce nylo tshi eoecrtpr uess +Ca
I pekicd NAMD acseueb ts’i ltirmutasyo, tub si ehetr ayn eedpre enraso rfo sh?it
You cna aenswr by oesrcsp of nlt.eaonimii ie"mCpoievtt noinsteacirt" kseam you hktni tymtsiuroal N.T oCrss tou ABAG and egic.nyl In het ertcxo os am.gletatu rpcooMbiaett dolwu amen ehet'rs csnedo sgmresnees odelnvvi nad eht rcopeert oldwu ont rtsmanit cucma.li Hnece NDMA.
sude ni nlog trem onpaittetnio au,gnal(eg ,myoer)m aMy sloa aply a oler in eegn ttonansipcrir in ouersnn
1) ADNM si a aamltteuG cerropet yupts2e )b PAAM si a tbypsue fo MAND hatt is ianlliiyt ctdtvaaie yb mtgaeualt 3 )aleesre NDAM erectorsp ear udnfo erna MAPA srteopcer but are tno aittvaced by lwo slvlee of eattulmag lsaeree ude to a Mg ion ‘ncol’bkgi the eac4n )nlh enuFtqer oAictn tpeoatnli t&g—; luattminosi of AAPM &g—t; perildoeasz tpos ytaipncs ronneu &tg;— loavteg tedpneedn Mg ckobl fo NAMD crepoetr ovredme ) 5 iuxnfl fo aC uhtorgh MDNA —g&t; sscaeu evne erom AAPM rpteoresc ot be dsieetnr toin hte enmermab (O:NTE AMAP is osvneriesp to Ca nda aga )et6tlmu) seeuBca hetre ear meor stprecreo ot dsprnoe to ,it eht lecl is meor isesvnpeor to eaulttgma
lal the heosrt a oenvpntctiiemo csnie tehy vaeh pspc(tcfecyciiesiifi ,)nglidsa MDNA si hte lyon ncenveehteselcno(i ocveimeiptt tc,orerep) hsa a idglan esit adn ca , na and hmee.n.g.c mietvtpeoci
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My mian ayaemG skt:lawe-tatau = oamrj iryxatotec onmtrrrauntset.ei woT ptsye of :oep r1t)recs ri,tptcbaomeo mots of which era tinayprsepc iG icwhh elsda ot eecesadrd AMDN teporerc tviacity adn ksir of ,tycictiixoxioet ro ypniasottspc Gq peetcrsor ttha alde to eareisnc N,+a ,+K dna rsdaeceed aemttlagu scusae atnzadolproeii dna cineardse M++g apmncsltdiee and NAMD rrcpoeet itcvyait dna isrk fo tyctcixoitexoi, adn 2) onctiropio elncshna nnciuldig DAMN dan enkAaiaAMt/P slenach,n hhwic lla allwo eipfnocsnic tincoa uxnfli, ubt nlyo AMDN lawols ++Ca flixnu (and onyl ni a levagot pndndeete anmnre rtfea ciesiftnfu ilnrtzaidoaoep ash dsdiepacl hte biihitonr +gM+ oni in het e.can)lhn
BAAG nad cnilegy = biytorhnii rumttrnes.ortasein 1) GAAAB- nda AB-ACG = oniptriooc aennlshc htta lade to uelxf of Cl,- adn eiseptd tish ngcuasi iaz,nretladipoo eth euornn ltisl yatss ebwlo igtrsen tioptlen.a -ABGAA ninibgd stie rfo ureat,tbasbir desotisr, A,AGB adn itniooprcx = insedi orpe fo .ancnelh A-ABGA idinnbg seit fo denseienbzzoaip = outdies fo proe fo n.nahelc )2 cynlieG ncahnle is a eryv sirlima -lC exufl e.lnhcan 3) A-ABGB is a aoptebmitcor lnachen htta atesivtca Gi adlgnei ot ceeasrdde AcMP hchwi aecsvttai fulefx +K nnshealc dan biistnhi +C+a nfxilu ncasenlh aelngid ot oprlh.eoyzrapainti
oeiniBcg eanims = scaaeimeohtnlc enpdimao (tioacdrnoion of boyd enmm,toev rweda,r ov,iinmtaot r)oic,mrnneteef neirreopnihepn el,p(se fk,seewansul ,tnaoiettn efindeg rvb,iehao nienperhpie e(sltwo aocnroienttnc in CN,)S puls tnsoireno lep(se, lwesaneku,sf odesesipn,r iatyexn, aun)ase adn sheaimtni oasula,r( ietttnna,o rgel,ayl tsseiu agaemd, adn aym cienenful bldoo rnabi ).lfwo bui,losvyO lla of tshi si in diaoidtn to rnigaecred unosmertrnnosisai and ,tlihfg rhig,ft dan fthig srnoe.esp
PAT and hrote riunsep = eaciortxty nmsrotsiisan, doelse-acer tihw hetro omlseullmecla- nsrstrn.rtoemetaiu Asdneineo itn's ssyaaicclll dcediroens a rarimestnoutentr eeausbc it t'nis e/atsesrlrdedoe in ++Ca nendtpede n,enrma utb eerdvdi form TAP reebof vhgina na rtietxaoyc te.paitlno
ylclAeotecihn = aomrj etirtsmnteraurno vdinovel in tarnsunsenmirsioo vai uamnicsr dna iciconnit sceo.retpr
Ppeidet eromueatrritsntsn = ynocomlm rlsedaee as ippoteerdp elrgar crpeosrusr hatt rae ecalved by isicefpc neysemz hatt erwe ni teh asme mserrunattirnote eiscvel puon s.rlaeee ieFv pteys = ntgar/bui d,iepsept doioip etpspi,de rpyatiuti ,siedtpp ltpahcyoaihm slnreiaeg ,mreooshn nda toseh otn idlssae.ifc aEepmxsl = rsrprouec taht isgev irse to btaecunss P c(m,iouphspap ecotorxn,e dna ITG dan desleear frmo almsl tmrediae PSN C ierfbs htta stimatrn pain and rrmeepttaeu notimorfai,n wluorefp esohytinep,v hdeitiibn by odiipo pede)it,sp uiornkienn ,A eopiuentderp ,K dna ptrneuieoedp amg,am and oiidpo tiesppde liudingnc natlp oslldakai e(ikl p,mrineh)o tnhiytsec idopio eisavriv,tde and norhpensi,d nsdinpyo,rh dan lne.pahnsike nI nagrlee oioipd piesetdp are ernsestdasp (..ei iagaealsn eac)s,imhmn volnidve ni expocml iahesbovr xsa(lue tatct,rnoia vgeirisvabime/ssseugs ihaver)s,ob dna cailtipdme uhg(oht ton ni)evedifti ni hptiscryiac ssirdoedr.
vleOalr, tretsaisormnnuert = ytep p:yets m-sullalclmeoe teatrirtmssn nad ree,npdotpsiue heerw slelmasmlulce-o tstrrnesmiat aer fetsra dan dieatem riapd castynpi iissnatsnrmo e..(i egaonrdn SNS i/ihtftr/ihggghtffl cikuq p)eers,nso eewhr as snpiteprouede (olang ihwt cgoliiob neamsi dna smoe lalms coeulelm sna)trermttsi ear solrew adn atimdee rdua,lag nogpoedrl rsiarsootsinu.nenm
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