effect of glutamate antagonist on pt with acute cerebral infarction = targets NMDA receptor
decreases calcium entry into neurons = decreased excitotoxicity = promotes recovery from acute cerebral infarction.
ougTh esuinqto.
aRlcel that aimeetMnn aezl'hmiesr( dru)g is a ANDM toeprecR aoAnitngts htta hespl npervet xoctxycetiito by onBilcgk 2+aC eyntr. ht'Tsa owh I bermmeer tih.s
a picture for better understanding https://2e.mindsmachine.com/asf04.02.html
^ link is dead :( (they published a 3/e) but here is the re-route to the new site if anyone wants to dig in https://learninglink.oup.com/access/watson3e-student-resources
ADMN orsetrpce in stih scae rea bgine sdue rfo olng emrt otiotapennit thwiin eht anbri and tou fo lla of there coshcei ylon ihst eecrotpr sues aC+
I ckipde NDAM ebsuaec ’tis tu,losamriyt utb is erhte any epdeer nsoaer fro t?his
You nac easnrw yb rsposec of nmiitenai.ol mptetvCio"ei oisarnett"nci masek uyo tiknh myuatisrlot NT. srsCo uto AAGB nad ign.ycel nI eth rcexot so tg.eamluta ptocebaorMti uodwl maen hes'ert cdeson eesemsnrsg ievlndov dna het rcpoeter wdoul tno nritastm a.cilmuc cneHe .ADNM
sdue ni gnol trem tatotnipinoe n,glaaue(g romey),m ayM laos ylpa a loer ni nege asrnntirptico ni osnrnue
)1 MDAN si a tuaemaGlt pcroeret y)set2u bp AMAP is a pysuebt of AMDN ttha is tiayillin edcttaaiv by etguatmal 3a)l eeres AMDN ceoprters era udonf rnae AMPA osrrtepce tbu rea not taiadtvce by low ellvse of mlaeguatt elaeres ude ot a gM oni ikbl’c‘ong the e) nlanc4h entFeqru tiocnA napeotitl g&—;t itltmoisuna of PMAA ;t&—g orapdziseel otps cpitynas rnenuo t—&;g vaetlgo pennetedd Mg okcbl of MDAN potrecer dermeov )5 nfxliu fo aC htuhogr MAND ;g&t— csause enev orme MPAA rcreepots ot be eirtndes ntoi teh menremba OT(EN: APMA si poevsnries to aC nad a gtte)ual)m6 eBscuea htere aer oemr soteepcrr ot edrsonp to ,ti het ellc si reom nsosperevi ot mtegaalut
lla hte rshteo a nmpvniteootcei esicn they vahe fcieiiyecsci(pptisfc ingd),sal ADNM si the loyn esene(eeonncvctlih tiieepovctm oeept,rcr) ahs a anidgl esti nda ac , na and .m.gnce.he pteovmietci
submitted by ∗nwinkelmann(366)
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$379$49S,o fro osme saren,o somatretrennsiutr si oiesthngm 'evI SLYAWA ggtulrdse .i.t.wh lbbaorpy ebaeusc I snwt'a thtuag ti well so enrev alelry erelnda it, utsj nearlde nehuog for arevhwte .exma I sjut noufd siht obo hhtgrou CBNI and sti CAFITT!NAS 'Its morf 0201 os ighmt eb ol,d tub ti saw .taegr uYo can aehscr thguorh eht book adn ndfi eht hrpat.ecs I rtepyt much jtus etnw hrguoth lla of hte nmeuortnsritaetr pheacr.t himksNh/niw9Kb.tt.nc1s//pww.7l.vo/0/Bno:gbo9
My nmai atwtatakes-lGamau y:e = arjmo ctioyrxtae otn.uenmerristrat oTw sypte of e:e o1)psrtcr ecti,omrotabp tsom of wchhi era eptiarpnscy iG chwih alesd to rsaecdeed NDAM ptcroeer iacviytt nda krsi of titoioxtycix,iec or istctyppsnao Gq orcerpets that edal to eersicna aN,+ +,K adn dcdeeraes ataluemtg esucas tznaiardoieopl dan naicserde ++Mg ltmsdcipenea nad MADN rtoecper tityiavc dna iskr of oitiixeycxcott, nad ) 2 inioorctpo cneasnlh cluiindgn NDMA adn iAPkMa/taAne ,hlasnnec hiwhc lla llwoa fscnoiiencp tcnaio ,xnlfiu utb nlyo AMDN saolwl C+a+ xinufl n(ad noly in a legavto endtdepne mnrnae tafre uinfifesct iraodtpnzaoiel ash adepdlsci eth obrnitiih +M+g oin ni the e.h)nclan
AAGB nad gcyinle = binoyrhtii n.irremeussontatrt ) 1 BAG-AA dan CBA-AG = oonciptior esnnhacl htta dela ot flxeu of lC,- nad petesdi shit nugisac ieaztiroano,pld eht uennor ilstl tyssa blwoe ensrigt ittepnola. GAA-BA gbnndii itse for traua,irbestb eri,tdoss GB,AA adn ioiortxcnp = neisdi epro of hen.ancl AAGA-B nibnidg tsie of zzdnpaneeoibesi = ietdosu of oper fo lnae.hcn 2) lGeicny nhanlce si a reyv lsiriam lC- eflxu anh.enlc )3 ABGAB- is a cembpottaior cnlaneh hatt eicatastv iG ilanged ot edcasedre cAMP iwchh caatseitv fuelxf +K asnlcnhe dna iihbtisn +Ca+ linfux annesclh dlegian ot zlitoerhprin.poaya
giencBio msniea = ecatsnimlhcoae odiaenpm arn(coiditnoo of doby otnmv,eem aerwr,d ia,intotmov roinneremftce,) hpeieroeprinnn (,slepe ,lsneufwesak tteoita,nn degeinf hevbroia, iipeheenprn eo(ltsw rnnnattiocceo ni ,N)CS lsup ioernntso (lepse, eakslf,newus eiredsn,sop n,yixaet sne)uaa and asmiehnti lsa(,uoar not,tateni lgeylr,a usesit aaeg,md and may nefnlcieu obdlo ibnra o)lw.f olubivsOy, lla fo tsih is ni dtidoani ot rigderaecn nainumnseiotrrsos and ,gfihtl tg,hfir dan hgtfi sreson.pe
ATP dna toerh rinpeus = ttirxeocay otia,mnsrissn e-coerdeals hitw rhote ml-elsuloaelmc totriaensm.strrnue ndAseenio ni'ts slcliacylas ddsnocreei a tesrtoninutreram caueesb it tin's sdrea/deolteser ni ++Ca eepdendnt nanm,re utb idredve from TAP fboree hiagvn na xoiterytca nota.lietp
celioyhnAclet = rjoma rsrtaerumetontni lonedivv ni usonarnioesnitmrs aiv acrunsim nad octnnciii epesc.rrto
pdetPei miettntesansourrr = oomlnycm ldrseaee sa dpprpioete rgreal prcssoerur ttah rea lecvaed yb cscifeip zsyenem atht erwe ni eth maes oeattenirnrstrum vceeisl puon sreee.al Five tespy = igb/nraut ppe,dtise ioiopd pedistp,e iaitptury ied,sptp ahtmiychpaol ilaerngse nosoehrm, nda ehots not aslfi.ecdis psxeEmla = rrpecsoru thta evgis sier ot tsbsanceu P pc(soiphma,pu et,ronxceo and TGI adn eesrlade rfom mllsa maediret PSN C freibs htat nmsttrai nipa nad uttrmreeape aintnfomi,or reuwlfpo opeinhstvy,e hibetidni by poiiod p,esdetpi) inreokunni A, uidtrenopeep K, and teieuppendro ,gamma dan pidoio peetsdip gcniinldu nlatp lkodalsai l(iek oirn)mpeh, tiynthesc dpooii davvstee,iri and rhnpioen,sd do,nhpynirs dan e.ksipehnnal In nergeal dipioo ptspieed rae sapenretdss (i..e nasgelaai aiem,hmscn) nedvlvio ni empxlco oeisabrvh uea(sxl ,taaitotrnc seseiva/isbrisgvusmeg vhao,rsib)e dna ilamiepcdt o(hthug not dinitie)vef ni hpicyirscat oiesddr.rs
lra,evlO etanetnrsuosrimtr = pety ypste: oelealsucml-lm rrmssniattte dna upeisneropet,d wrhee lsemslaeuo-clml raimssttrnte era asrtfe and edeiamt drpai cnpityas smnosainsirt e.i(. dornnaeg SSN igft/gl/hftfighihrt uqcki ose,sne)rp erewh sa enpordueeitps anolg( ihwt iocibogl isaenm adn meos llsma uoeemlcl tastneirs)mrt era solewr dna iedaemt aulgr,ad nodorlpge eosit.mronruasnnsi
Smeo iuecpst:r u/ntnsdotwcevefthmeootaeroe__dermhn.eskeihtmdkr:/t/uip/aiis..bwlun/p_vpurawrpt, Rft-6gfh0hB4ag/gr7/-/2i-reoa:cpb61u.s116nn3w0ataspPt88p/rieac-per9reeud3ttr1eee/A6fgle/eoTocadhb3belBaf.2smp4grtAl5swi-/bw-2i34disinG0ro0as-c0d1u-r, and tl;hl6r3pbnlc:aU61iege1os7h&n2.5a/iw.-ee#w_f-5gmex-g-ebgudaeda1-d1balgbbe-dtsidfr0h./s34=f/pxt-a-tteaw/2/arn=8wi/f09
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