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Retired NBME 23 Answers

nbme23/Block 2/Question#32 (reveal difficulty score)
A 2-year-old girl is brought to the physician ...
N-methyl-d-aspartate (NMDA) 🔍 / 📺 / 🌳 / 📖
tags: pharm neuro repeat

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 +19  upvote downvote
submitted by nwinkelmann(366)
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,So for omes rsaeon, utoetrtiasenmrsrn si isnmtehgo eI'v YALAWS tlgeursdg ..htw.i ypbbloar cseaeub I tw'san athgtu ti well so ervne lealry enrelda t,i ujts reeland ghnoeu ofr aeevhrtw aex.m I ujst fudon shti obo uhtrogh NCIB nad sit TCANT!AFSI stI' from 1020 os igthm eb ,odl btu ti aws eatg.r Yuo cna chesar rhougth teh kobo nad fndi eht rahpe.sct I pyettr uchm juts ewnt hhrotug all of teh nnmrttutrereaiso ra.epcht :7K9/bBt/9wolvowknwh/i/p0nibh1sc.g/.m.nt.osN

My mian ayaemG skt:lawe-tatau = oamrj iryxatotec onmtrrrauntset.ei woT ptsye of :oep r1t)recs ri,tptcbaomeo mots of which era tinayprsepc iG icwhh elsda ot eecesadrd AMDN teporerc tviacity adn ksir of ,tycictiixoxioet ro ypniasottspc Gq peetcrsor ttha alde to eareisnc N,+a ,+K dna rsdaeceed aemttlagu scusae atnzadolproeii dna cineardse M++g apmncsltdiee and NAMD rrcpoeet itcvyait dna isrk fo tyctcixoitexoi, adn 2) onctiropio elncshna nnciuldig DAMN dan enkAaiaAMt/P slenach,n hhwic lla allwo eipfnocsnic tincoa uxnfli, ubt nlyo AMDN lawols ++Ca flixnu (and onyl ni a levagot pndndeete anmnre rtfea ciesiftnfu ilnrtzaidoaoep ash dsdiepacl hte biihitonr +gM+ oni in het e.can)lhn

BAAG nad cnilegy = biytorhnii rumttrnes.ortasein 1) GAAAB- nda AB-ACG = oniptriooc aennlshc htta lade to uelxf of Cl,- adn eiseptd tish ngcuasi iaz,nretladipoo eth euornn ltisl yatss ebwlo igtrsen tioptlen.a -ABGAA ninibgd stie rfo ureat,tbasbir desotisr, A,AGB adn itniooprcx = insedi orpe fo .ancnelh A-ABGA idinnbg seit fo denseienbzzoaip = outdies fo proe fo n.nahelc )2 cynlieG ncahnle is a eryv sirlima -lC exufl e.lnhcan 3) A-ABGB is a aoptebmitcor lnachen htta atesivtca Gi adlgnei ot ceeasrdde AcMP hchwi aecsvttai fulefx +K nnshealc dan biistnhi +C+a nfxilu ncasenlh aelngid ot oprlh.eoyzrapainti

oeiniBcg eanims = scaaeimeohtnlc enpdimao (tioacdrnoion of boyd enmm,toev rweda,r ov,iinmtaot r)oic,mrnneteef neirreopnihepn el,p(se fk,seewansul ,tnaoiettn efindeg rvb,iehao nienperhpie e(sltwo aocnroienttnc in CN,)S puls tnsoireno lep(se, lwesaneku,sf odesesipn,r iatyexn, aun)ase adn sheaimtni oasula,r( ietttnna,o rgel,ayl tsseiu agaemd, adn aym cienenful bldoo rnabi ).lfwo bui,losvyO lla of tshi si in diaoidtn to rnigaecred unosmertrnnosisai and ,tlihfg rhig,ft dan fthig srnoe.esp

PAT and hrote riunsep = eaciortxty nmsrotsiisan, doelse-acer tihw hetro omlseullmecla- nsrstrn.rtoemetaiu Asdneineo itn's ssyaaicclll dcediroens a rarimestnoutentr eeausbc it t'nis e/atsesrlrdedoe in ++Ca nendtpede n,enrma utb eerdvdi form TAP reebof vhgina na rtietxaoyc te.paitlno

ylclAeotecihn = aomrj etirtsmnteraurno vdinovel in tarnsunsenmirsioo vai uamnicsr dna iciconnit sceo.retpr

Ppeidet eromueatrritsntsn = ynocomlm rlsedaee as ippoteerdp elrgar crpeosrusr hatt rae ecalved by isicefpc neysemz hatt erwe ni teh asme mserrunattirnote eiscvel puon s.rlaeee ieFv pteys = ntgar/bui d,iepsept doioip etpspi,de rpyatiuti ,siedtpp ltpahcyoaihm slnreiaeg ,mreooshn nda toseh otn idlssae.ifc aEepmxsl = rsrprouec taht isgev irse to btaecunss P c(m,iouphspap ecotorxn,e dna ITG dan desleear frmo almsl tmrediae PSN C ierfbs htta stimatrn pain and rrmeepttaeu notimorfai,n wluorefp esohytinep,v hdeitiibn by odiipo pede)it,sp uiornkienn ,A eopiuentderp ,K dna ptrneuieoedp amg,am and oiidpo tiesppde liudingnc natlp oslldakai e(ikl p,mrineh)o tnhiytsec idopio eisavriv,tde and norhpensi,d nsdinpyo,rh dan lne.pahnsike nI nagrlee oioipd piesetdp are ernsestdasp (..ei iagaealsn eac)s,imhmn volnidve ni expocml iahesbovr xsa(lue tatct,rnoia vgeirisvabime/ssseugs ihaver)s,ob dna cailtipdme uhg(oht ton ni)evedifti ni hptiscryiac ssirdoedr.

vleOalr, tretsaisormnnuert = ytep p:yets m-sullalclmeoe teatrirtmssn nad ree,npdotpsiue heerw slelmasmlulce-o tstrrnesmiat aer fetsra dan dieatem riapd castynpi iissnatsnrmo e..(i egaonrdn SNS i/ihtftr/ihggghtffl cikuq p)eers,nso eewhr as snpiteprouede (olang ihwt cgoliiob neamsi dna smoe lalms coeulelm sna)trermttsi ear solrew adn atimdee rdua,lag nogpoedrl rsiarsootsinu.nenm

Smoe sctir:upe trwvniusodean/o_hwi_aetrb.mnemsemphup/r/okpc/ehn:s.eittdpf_u/twrodtleuavti.rek, efs60m08.sr-aa6ni1isbpc-aerpwwagergtr/-eaw-t3hi2ersaoR1AGte7h1ocd/d2soB4uiul3i2ns/toA-T00agBrc/e-repce4p3uali-9Pr5gn.-/fd60lf8b1:petf146/egthd3bbr/, dna .adlax3at93-t1gbm/6dn-ut:whs1h1-elwpneebaier-2c/o-_aidw-e2r.twf/g5xlnfb/feeg&e;0e7-s#0Udigspdaih/1l/4a8af.gr=5t=-6bb

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sweetmed  ihsT si migana.z hktan yuo +
sweetmed  Tshi si inzama.g tkhna uyo +
paulkarr  ..hWa.o +
brotherimodu  rotSh ivdeo seemono psodte from -BEN1M2 aews:rsn HhzptD:oo2ebt/?.y.cv/uuwstQ=mhwcw4wo/a-twuv +6
dorischang  id'nDt sfihin eigrdna ths,i but it olosk maowese +3
kcyanide101  If you nnawa iwetr a ttex book jtus asy o.l..s.lo :) +

  • effect of glutamate antagonist on pt with acute cerebral infarction = targets NMDA receptor

  • decreases calcium entry into neurons = decreased excitotoxicity = promotes recovery from acute cerebral infarction.


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 +19  upvote downvote
submitted by sympathetikey(1600)
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Toghu esnqu.ito

Rclale atth mMntaenei reil'sam(ezh )ugdr is a MNDA Rrtcepoe oAnstgntai thta hlesp epnterv xctxciiytotoe by Bcoikgnl 2Ca+ tryne. 'hsaTt ohw I eemmberr tihs.

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veryhungrycaterpillar  tnrt/9r/0eewo/nrcojt/.9gc/:owto3s.h0/wis.1upthsnr Gtea illtte r,ead dan hits is hte raepp ehyt terypt hmuc sbdea shti etnoqusi no. +
veryhungrycaterpillar  niLkde eth orgwn reppa. Mante to nilk sith noe: mln6.8l2ht6irmhe7.0/nctsb/c.i:tpwo/gsw5/i/pavnc.M/wPC +

a picture for better understanding https://2e.mindsmachine.com/asf04.02.html

^ link is dead :( (they published a 3/e) but here is the re-route to the new site if anyone wants to dig in https://learninglink.oup.com/access/watson3e-student-resources

+/- drdoom(1206)

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 +4  upvote downvote
submitted by spow(50)
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  • A) A-AGAB rsrpectoe tle l-C in
  • )B iGnlecy si dseu ni eht alipsn rdco as na oiibtyhinr auirntntsmrte;roe also tels l-C in
  • C dan E) tabcprMioeot tealaugtm crteposre era prtioG-en cpelodu
  • erheoe,rTf eth ylon ightn taht lcdou tel C2+a ni si ANMD pcertsroe
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thotcandy  croncdgia to hits, TH53 is na oin chnanel aiy(lnm aN dna ,K ubt semo a)C so thta wsa kdnia ffey imo +


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 +3  upvote downvote
submitted by lfsuarez(160)
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NMDA creproets in isht caes rae igenb duse ofr nglo emrt annoietoptti iihnwt the irabn dna out fo all of rthee shicoce nylo tshi eoecrtpr uess +Ca

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 +1  upvote downvote
submitted by chasingdreams101(4)
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I pekicd NAMD acseueb ts’i ltirmutasyo, tub si ehetr ayn eedpre enraso rfo sh?it

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tea-cats-biscuits  Teh Q is yllcuata ksanig wihch fo the repostcre eus Ca+ ,snio and fo eht heicsco vgnie nyol ADMN prercsteo do so. +32


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 +1  upvote downvote
submitted by adong(144)
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You cna aenswr by oesrcsp of nlt.eaonimii ie"mCpoievtt noinsteacirt" kseam you hktni tymtsiuroal N.T oCrss tou ABAG and egic.nyl In het ertcxo os am.gletatu rpcooMbiaett dolwu amen ehet'rs csnedo sgmresnees odelnvvi nad eht rcopeert oldwu ont rtsmanit cucma.li Hnece NDMA.

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 +1  upvote downvote
submitted by an1(114)
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sude ni nlog trem onpaittetnio au,gnal(eg ,myoer)m aMy sloa aply a oler in eegn ttonansipcrir in ouersnn

1) ADNM si a aamltteuG cerropet yupts2e )b PAAM si a tbypsue fo MAND hatt is ianlliiyt ctdtvaaie yb mtgaeualt 3 )aleesre NDAM erectorsp ear udnfo erna MAPA srteopcer but are tno aittvaced by lwo slvlee of eattulmag lsaeree ude to a Mg ion ‘ncol’bkgi the eac4n )nlh enuFtqer oAictn tpeoatnli t&g—; luattminosi of AAPM &g—t; perildoeasz tpos ytaipncs ronneu &tg;— loavteg tedpneedn Mg ckobl fo NAMD crepoetr ovredme ) 5 iuxnfl fo aC uhtorgh MDNA —g&t; sscaeu evne erom AAPM rpteoresc ot be dsieetnr toin hte enmermab (O:NTE AMAP is osvneriesp to Ca nda aga )et6tlmu) seeuBca hetre ear meor stprecreo ot dsprnoe to ,it eht lecl is meor isesvnpeor to eaulttgma

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 +0  upvote downvote
submitted by zpatel(36)
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lal the heosrt a oenvpntctiiemo csnie tehy vaeh pspc(tcfecyciiesiifi ,)nglidsa MDNA si hte lyon ncenveehteselcno(i ocveimeiptt tc,orerep) hsa a idglan esit adn ca , na and hmee.n.g.c mietvtpeoci

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hello  eht stnqoeui assy octpevtmiie nitrnt,eiscoa i tihkn ihts si reefdnfti rofm vitcepmeiot .idbginn +


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