This question asks about the mechanism of phototherapy as it relates to neonatal jaundice. With phototherapy, bilirubin is simply converted to water soluble isomers that are then able to be excreted by the kidney. This however does not conjugate the bilirubin.
abhishek021196Physiologic
neonatal jaundice
At birth, immature UDP-glucuronosyltransferase = unconjugated hyperbilirubinemia = jaundice/
kernicterus (deposition of unconjugated, lipid-soluble bilirubin in the brain, particularly basal
ganglia).
Occurs after first 24 hours of life and usually resolves without treatment in 1โ2 weeks.
Treatment: phototherapy (non-UV) isomerizes unconjugated bilirubin to water-soluble form.+1
azharhu786The water-soluble form is called Lumirubin.+2
submitted by โlfsuarez(160)
This question asks about the mechanism of phototherapy as it relates to neonatal jaundice. With phototherapy, bilirubin is simply converted to water soluble isomers that are then able to be excreted by the kidney. This however does not conjugate the bilirubin.