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NBME 23 Answers

nbme23/Block 4/Question#22 (21.6 difficulty score)
A 40-year-old man with terminal small cell ...
Demeclocycline🔍
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submitted by lfsuarez(132),
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hsTi iaentpt ptesnser wiht a almsl clel crcmaanio chwhi is ryve nomcmo fro rapa nctloapsie dse.oynmrs In thsi esac eth cceanr is usniacg SA.IDH iocelynleDcem si a etntlrceicay anoititbci tath si soal seud to trate DAIHS

gabeb71  To add to ^ It is widely used (though off-label in many countries including the United States) in the treatment of hyponatremia (low blood sodium concentration) due to the syndrome of inappropriate antidiuretic hormone (SIADH) when fluid restriction alone has been ineffective. Physiologically, this works by reducing the responsiveness of the collecting tubule cells to ADH. The use in SIADH actually relies on a side effect; demeclocycline induces nephrogenic diabetes insipidus (dehydration due to the inability to concentrate urine). +13  
qball  And for you Sketchy people Demeclocycline is in GI/Endocrine ADH one with the bicycle and that "vaptans" are first line. +1