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NBME 24 Answers

nbme24/Block 1/Question#12

A 26-year-old man comes to the physician for a ...

Increased number of LDL receptors on hepatocytes

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submitted by m-ice(116),

HMG CoA reductase inhibitors block the ability of the body to produce its own cholesterol. The liver, unable to make its own cholesterol and still needing to do its job of making lipoproteins, needs to get it from somewhere. So, the liver increases expression of LDL receptors to take more LDL out of the blood for repackaging.