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NBME 24 Answers
A 26-year-old man and his 25-year-old wife come to ...
One in four will have 25% β-globin function and may require occasional transfusions
I interpreted "null" as meaning full deletion while the other heterozygous mutations was only a 50% decrease in the function. One child would inherit 1 null mutation and 1 50% mutation, which would leave them with a 25% functional gene.