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Retired NBME 24 Answers

nbme24/Block 1/Question#40 (reveal difficulty score)
A 26-year-old man and his 25-year-old wife ...
One in four will have 25% β-globin function and may require occasional transfusions 🔍 / 📺 / 🌳 / 📖
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 +31  upvote downvote
submitted by brethren_md(105)
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aMke a tnputen esuqar whit a srsoc of B B+ dna B ;0B +B nrsrpteese %50 tcninofu wiehl B0 snerprtees %0 ull()n in.unfcto So in htis esa,c the nhsdbau oulwd eavh a B 0B tpgeenoy while eht wefi sha a B B+ n.eptgyoe

Crsos fo sethe owt lwil etulsr ni teh fioollnwg ;eeptoysng ,BB 0BB, +B,B BB+0 BB = 0%10 funconti, B+B = 5%7 cftnoni,u BB0 = 50% tnfnc,iuo BB0+ = 52% ictnfuon

oS het wnresa lwli be 1 in 4 evah a 5%2 cniofnut eving the oyns.egtep

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tyrionwill  how utabo eht cchoie fo :D 1 in 4 hvea %50 coinutf,n chhiw si t.eru llahs 0%5 noicufnt sdene sfuaotsnrni? +
tyrionwill  In FA, it nfeeids bate sslaemtaahi onti oinrm AH(b2 5.g%)3&;t nda mojra bot(h HbF dna 2AbH og ufhrret ,p)u and eht joram dseen osuinnftrsa yrnutfe.eql oHw can we ktea sthi soaclsncifiait aedbs noup eauivqitnt way ekli in isht t?uisqeon how uhcm crpgaetnee fo itcnoufn telf dose ont dene a netfequr tounsrnas?if +
azibird  D sasy neo in TWO, not noe in .FRUO +6
hemehero  sI there a wya to wkon thta B0B+ will = 25% cnfn.otiu I asw tuksc ebnetew %25 iunoctnf nad %01 tcfonui,n but ndtl'uoc figeru otu woh to eorsan eetbwen teh wto fo et.mh +3
neil_simmons  hTe nietoqus sasy het eohmtr ash a tnaomuit ownnk ot secau %50 sreeeacd in bagto-ebinl geen uitfocnn fo one elell.a So if one lleela is konwgri at 50% +)(B nda het ehrto alelel is krwngio ta %0 ()0B, enth htat olduw neam hatt atlrciaupr ets fo ellsela lwdou onncuitf at %5.2 +2
twich22  hTe eyK rehe is hte naomw has 05% ceeearsd in conitufn "Of one alelel". tIs a ipsdut yaw to drow ti, utB ti mensa htta eno laleel skwro ta ,50% hwhic ludow eb B+. oS if you eahv a +/BB0 sprf,iofng the 0B gsvie %0 dna eth +B srwok at 05% aac,yticp so oyu lnyo aevh 25% fo or.nlma +
murad  meos oen xinapel iths ot em a,elesp ohw cmoe if eth rtmohe tiwh sih peetgoyn BB+ ahs 50% cuiofnnt fo oen le.lael wihle fi we teg hre noigfrsfp ptunen qaurse ew sierncdo teh oen ttha sah eth asme ognpeety sa hre +BB fo hanigv 57% noc?it?nfu +



 +3  upvote downvote
submitted by an_improved_me(91)
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I lefe eilk its etseh skidn of qeisuston taht alerly meka a trteta-kse cecse.ud uo Y doclu evah dudtesi oury holwe feli orf pSet 1, nad men..ec.tho up giaastn a iqsneout ilek shti. tsI egtnist speccnot atth euro'y fmairila hiwt e(.g. ilamaeaa,hB-tsset eneigs,c)t but in a way htat nsi't tmonseghi duyo' evre decrylti alrne. Yo u avhe ot ysta ,amcl nlyzaea awth ouy wk,on hwta het itsenoqu is ,ingaks catree a tgtyrsea to wneras, dna kloo at hwhci nawser si tbes.

I ynve oems fo o!y!u

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 +1  upvote downvote
submitted by medstruggle(21)
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Wtash eth eifneercdf bteenew srheouzg“teoy ulln iunotamt ni B oilgnb eeg”n dan e“styeurzghoo uotmtian wnonk to eucas %05 serdceea ni B ibolgn eneg cnofintu of noe lee?a”ll

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welpdedelp  I retintedrpe lun""l as ngminea ulfl tdnioeel hiewl eth htoer ouehsrtzygoe utontasmi saw nloy a %05 ederseca in eht fucot.nni neO hcidl wlodu thineri 1 unll mnoituta dna 1 5%0 uaonimtt, hhciw dwlou eeval tmhe hitw a 2%5 itunonlfac n.ege +18
j44n  A alht is hte eleo,tidn B atlh is natsmtiou no rrsoeompt ro scielp t.ssei +



 -1  upvote downvote
submitted by mynamejeff(0)
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I hntki E si saol ..aivbl.e 1/4 is BB/ nad rnheota 41/ is +BB/ . eTh /BB+ is amBatss-hiael nirmo erhew B cinah si enocdurupddre ofniutn(sc lyrna)olm and si sllyauu ps,tamcayomit rep AF 20(20 gp. 148).

hgtho?suT

Asl,o my rgtnusnieddna on aaahsmtBil-es from Dr. raStat dan rtisf iad si ttah tsi' ont tes ni soent htat B+ si 5%0 poortucidn. tI msees ot .yrav

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syringomyelia1  E ssya /21 tno /14 +1



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