NBME 24 Alteration in DNA gyrase (NBME Answers)

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Retired NBME 24 Answers

nbme24/Block 1/Question#44 (reveal difficulty score)
A 24-year-old man is brought to the office ...
Alteration in DNA gyrase 🔍 / 📺 / 🌳 / 📖
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submitted by ∗madojo(212)

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Going over other answers:

Alteration in 30S ribsomal RNA refers to aminoglycosides, tetracyclines, glycylcylines Alternation in RNA polymerase refers to drug like Rifampin Alterations in penicillin binding proteins would be for penicillinases

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submitted by ∗trichotillomaniac(121)

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cipro is a fluoroquinolone. the MOA of fluoroquinolones is to inhibit prokaryotic topoisomers II (DNA Gyrase) occasionally Gram (-) organisms like e-coli develop resistance by mutating their DNA gyrase so drugs like cipro cannot inhibit

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