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nbme24/Block 1/Question#44

A 24-year-old man is brought to the office because ...

Alteration in DNA gyrase

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submitted by trichotillomaniac(12),

cipro is a fluoroquinolone. the MOA of fluoroquinolones is to inhibit prokaryotic topoisomers II (DNA Gyrase) occasionally Gram (-) organisms like e-coli develop resistance by mutating their DNA gyrase so drugs like cipro cannot inhibit