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NBME 24 Answers

nbme24/Block 3/Question#1 (19.6 difficulty score)
A 3-year-old girl has a history of recurrent ...
NADPH oxidaseπŸ”

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submitted by m-ice(325),
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ishT iglr ahs ccnhori ntglmaoraosuu dseise,a ni hhwic eth iummen tsmsey nocnta yoprlrep mofr icrtavee xeygon ecpsesi ededen ot klli ooyctpsheagd .ngrsamsio hiTs si ieesllapcy bad wneh ldnigea ihwt tlasaace epistvoi isagomrsn le(ki Sptah,) baeesuc thsee mnssarigo rdealay ues laecaast ot akebr odwn ietrcaev ygeonx epessi.c eTh toms onmmoc scaeu fo iths cnnitdooi is a ottiamnu ni APNHD oa,edxis enlspreiosb orf eht nrnoetigea of eht uroeedxspi dicla.ra

et-tu-bromocriptine  To add on: If neutrophils don't have access to NADPH oxidase, they can still use the bacteria's own hydrogen peroxidase to create ROS and kill the bacteria; however, catalase + organisms will not have this hydrogen peroxidase available (because catalase converts hydrogen peroxidase to O2 and water). So then the neutrophils are screwed and have no way of creating ROS. +6  

submitted by faus305(6),

You know why I don't get chronic granulomas? Because I've got NADPH Oxidase. It makes OXYGEN FREE RADICALS THAT WIPE AWAY STAINS.