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NBME 24 Answers

nbme24/Block 3/Question#41

A 30-year-old man develops tingling around the lips ...

Sodium

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submitted by m-ice(116),

Tetrodotoxin, found in puffer fish, inhibits sodium channels. This prevents depolarization of cardiac muscle and neurons, which leads to death if consumed in high enough quantity. The symptoms are vague (nausea, diarrhea, paresthesia), so questions will need to give some form of history about eating at a Japanese restaurant or eating pufferfish to give you a big hint. There is unfortunately not treatment.