Quoting Dr Sattar, if an injury or cut is too deep so as the regenerative/stem cells are removed/damaged - then healing can only occur by repair. Thus, in this case, the stem cells of the lung aka Type 2 pneumocytes reside in the basement membrane - so, injury to basement membrane would damage type 2 pneumocytes and would NOT allow restoration of normal lung architecture. That's why maintenance of basement membrane integrity is the most important determining factor to distinguish whether tissue will heal by regeneration (restore normal architecture) or repair (fibrosis/scarring). Same concept can be applied to skin (basal cells) and intestines (crypt cells).
uoY vhae ot inkth buato it siht awy: the nstamebe ebmearmn si het “cfalsn”dgfio no chwih o[eireatts]vr hienlga urc.sco ,oS sey, tmes lscel (pety II smoye)petcun wdlou eb oivevldn ni taht alehnig sopcrse btu ehyt cdluot’n sterroe the oarlmn etictuhrecar “n(o oemtsr”i)bnalia tiuhowt hte eltek‘n’so of teh esbanmet mmrneabe ngietll mhet ewrhe to o,g ni ahwt riiecndto ot w,gor cihhw ayw si “”up, c.te fI teh emsabnte anmmbree is oedrsye,td uoy cna lltsi etg he,lgain ubt it ’notw be oeairdnzg ailegnh -- lli’t be rsiaeozidndg neliga,h wcihh esod ton pparea sa ormaln su.etsi (nozedisDirga alhinge si ttbeer than no ,gilhena tub thuowti a ,MB teh nregerniaegt slcle ’notd ehva yna dre“i”tnico dan erorefhet a’ntc tsoreer the onamrl ut.reearciht)c
I owuld tknhi erliuoonst oievnlsv the smet lecsl epty( II t.peysneo)cmu sI the acntti smteaben enbmaemr eth nwsrea ucaseeb ti tmisli a?epsdr
nac nnoaey xipneal ywh (D) aealitamsp is ?oteinccrr
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