Quoting Dr Sattar, if an injury or cut is too deep so as the regenerative/stem cells are removed/damaged - then healing can only occur by repair. Thus, in this case, the stem cells of the lung aka Type 2 pneumocytes reside in the basement membrane - so, injury to basement membrane would damage type 2 pneumocytes and would NOT allow restoration of normal lung architecture. That's why maintenance of basement membrane integrity is the most important determining factor to distinguish whether tissue will heal by regeneration (restore normal architecture) or repair (fibrosis/scarring). Same concept can be applied to skin (basal cells) and intestines (crypt cells).
oYu heva ot ntkhi outba ti sith awy: teh etsnebam remamenb si eht “ifsglncdfa”o on ciwhh eirostert[]av heangil cocrs.u ,oS s,ey smte cslel (eytp II pueotc)yenms dolwu be ldnoeviv ni atth hnelgai spsrcoe but eyht touldnc’ erortes teh larnom eithcrrtcaue (no“ bma)os”rneliait hwituto teh lk‘tso’nee fo teh nmebeast bmrmeane igleltn mteh eewrh to ,go ni whta retidicon ot ,rgwo wihch yaw is “p,”u etc. If eth nmaetesb rbnammee si ,rtdoyesde uoy acn litsl get lenihga, utb ti ’twno be zneogaird ealhign -- tli’l be ioidzasegrnd ,ginehla wchhi osde otn aprpae as olamnr t.isues gaDsnizreoid( elhgnai is ebetrt htna no ,ehalgni tbu hutitwo a B,M teh etingeernrga escll tdno’ have nya nriid“etoc” nad eethefror c’tan terreso teh nmlaor hauee)i.rrtctc
I uldwo ikhtn itlruseoon nevvolis teh mtes leslc (tpye II o.)tepumsynec Is hte cattni emansbte brmaneme het rsenwa uebaesc it iitlms arpsde?
acn ennoay iaelxnp ywh (D) plsaaaeitm si o?cnietrrc
submitted by ∗bubbles(79)
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$279$49neBsaetm rambenme ginttyrei si eth ntidaneertm fo lful gunl eeyvrrco flwiogoln uaymplron .tnsuli
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)1( osls of mbseaetn benmamre tgtnriiey si laticrci in rdmneigtnei the tn“ipo fo on ,rn”eurt nda stoencribtu ot het iniaylibt to asteiebhslr aonlmr lgun etchrriaucte wthi poonrtomi fo iifrssob;
(2) sosl fo lelapeiith csll,e hlateieondl cls,le dan sanetbem emerabnm rntieityg ni sulau tiairitlnste euoipnnma dosstiaaec thiw tiohaicidp lprumyano oibfsrsi sdale ot eeyrdstdo lngu iertrchauect dan pperaulet i;sbsfior
)(3 nagtmrnriofs wgorth ocβatrf- is en,ssacrye tbu not ilneeryt etnicuisff, to eopotrm paetnmren rs;bisofi
4() strtpeiesn nnitrraini/tayiget/njur si ccraltii rfo hte gpantiporoa of obif;sris
(5) doiichpiat rpunyamlo isisrbfo si na lxemaep of a ocpsers tadelre to teh iecsesrepnt fo na as)ntei(”“,ng corcihn tmnln,aamifoi nad srsf;biio adn
6() uneiqu slcel rea licticra eclulral yspreal in the ignlroutea fo rfi.obsis
acotii:ntlgcr1/P6.//t/4cw2mwec:apv/inb4Cw.2sthtl.5sn/.phiminoM
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