turtlepenlightThis makes sense, but I was thrown off by the "normal-appearing" b/c wouldn't AIS pts not have pubic hair?+2020-01-21T22:40:34Z
drzedThey just say it's a normal appearing 17 year old girl; not that the external genitalia are normal appearing. +12020-02-01T20:07:36Z
meningitisThe above explanation is correct (disregarding the hard to read and unprofessional dialect) but just in case anyone was wondering:
chromatin-negative= Just a quick way of knowing it was a boy. The term applies to the nuclei of cells in normal males as well as those in individuals with certain chromosomal abnormalities+112019-06-04T01:41:27Z
yotsubatoTurner syndrome patients are also chromatin negative as well though....+32019-06-12T09:42:22Z
sympathetikeyI didn't know a complication post-meningitis was lack of humor.+22019-06-13T02:09:35Z
sympathetikeyAh, didn't read the last line. Yeah, that is taking it a bit far +32019-06-13T02:10:51Z
niboonshyall are haters. this is the first explanation that has ever made sense to me+22019-06-23T02:19:23Z
whoissaadHow does chormatin-negative indicate a normal cell? Isn't chormatin just condensed DNA? +12019-07-15T20:21:17Z
cienfuegosAccording to this paper most individuals with Turner Syndrome are chromatin negative: "One of the initial laboratory procedures used to confirm or rule out this diagnosis involves a sex chromatin determination from a buccal smear. Cells from the lining of the mouth are stained for the presence or absence of X-chromatin or Barr bodies, which represent a portion of an inactivated X chromosome. The typical Turner’s syndrome patient, who has 45 chromosomes and only one sex chromosome (an X), has no Barr bodies and is, therefore, X-chromatin negative.
This abnormal X-chromatin negative finding in the majority of Turner’s syndrome females is similar to the result found in a normal male, who also has only one X chromosome, and differs from the X-chromatin positive condition observed in the normal female, who has two X chromosomes. Occasionally, the patient with features of Turner’s syndrome is found to be X-chromatin positive."
hyperfukusi really hate haters this is awesome! +2019-08-07T07:01:09Z
selectuwto add to the above, free testosterone is aromatized to estrogen leading to breast development+2019-12-22T22:54:35Z