NBME 21 Answers : Block 1 : #28 = A 47-year-old man is brought to the emergency ...

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NBME 21 Answers

nbme21/Block 1/Question#28

A 47-year-old man is brought to the emergency ...

Mixed venous oxygen tension

+5 upvote downvote
submitted by nicnac20(5),

Mixed venous oxygen tension is the amount of oxygen bound to hemoglobin as it returns to the right side of the heart after traveling to the tissues.

Decreased oxygen delivery to the tissues due to decreased cardiac output leads to the tissues extracting more oxygen from the passing RBCs than they normally would, which decreases the overall mixed venous oxygen tension.

pparalpha A helpful equation is CO=rate of O2 consumption/(arterial O2 content-venous O2 content): Fick principle If CO is decreased, then the difference between arterial O2 content and venous O2 content is increased +2

+1 upvote downvote
submitted by kentuckyfan(13),

I get why the mixed venous oxygen tension decreased. However,, isn't the systemic vascular resistance also decreased?

yb_26 no, decreased CO => peripheral vasoconstriction => SVR will be increased +2

yssya1992 No SVR will increase due to RAAS and SAN thats why we decrease afterload in HF treatment ( ACEI, ARBs ) +2

snafull Wouldn't pulmonary vascular resistance also be decreased here due to pulmonary vasodilation in the setting of an MI? +

cienfuegos @snafull: my initial thought is that we would see pulmonary vasoconstriction because of the relatively low oxygen tension (that results from the low cardiac output). +1

-1 upvote downvote
submitted by hayayah(345),

Mixed venous oxygen saturation (SvO2) is measured in the pulmonary artery. SvO2 samples the true mixed venous blood leaving the right heart. Measurement of mixed venous oxygen saturation (SvO2) from the pulmonary artery has been advocated as an indirect index of tissue oxygenation.

In cardiogenic shock you have decreased CO --> decreased O2 delivery --> decreased SvO2.