Type II hypersensitivity
reaction. Intravascular
hemolysis (ABO blood
group incompatibility) or
extravascular hemolysis (host
antibody reaction against
foreign antigen on donor
RBCs).
This is acute hemolytic transfusion reaction, I believe. Type II HSR so she’s forming antibodies against the ABO groups on the blood cells. Complement is induced by antibodies.
kfratta1But with hypotension in the stem I thought more of anaphylaxis due to IgA def. Why would a T2 HSR give you hypotension?+12019-05-31T15:53:19Z
2ndmedschoolI think the hemoglobinuria is the key. As I’m looking at it it seems that anaphylaxis would cause hypotension, urticaria, itching, wheezing.
ABO incompatibility is the only one that mentions hemoglobinuria.+22019-05-31T15:53:45Z
hyperfukusabo incompatibility and rh incompatibility with mom blood rxns are gonna TYPE 2 no matter what it looks like +2019-08-11T20:25:10Z
to snoo-finity ... and beyond!
submitted by mattnatomy(21), 2019-05-22T23:00:09Z
Diagnosis: Acute Hemolytic Transfusion Reaction
Pathogenesis:
Type II hypersensitivity reaction. Intravascular hemolysis (ABO blood group incompatibility) or extravascular hemolysis (host antibody reaction against foreign antigen on donor RBCs).
Presentation:
Fever, hypotension, tachypnea, tachycardia, flank pain, hemoglobinuria (intravascular hemolysis), jaundice (extravascular). Within 1 hour.