iD:ssngaio eActu Helmtocyi nfasrsuTnoi oeinctRa

sginatPe:heso

eyTp II t soieyenyrrti.iptiheanvcs socn imutharIvalsyrlaes AOB( bouogrdo pl t)aclityinoiibmp ua retcavaslrxor lessmhoiy ntboy sodta(ih ranoitce t gfgnsineiarao nianget no odrB RnCs)o.

Preteanos:tin

,vereF snhonyotiep, tihrctyphd,,aeynacaaac lfnka na,ip iaroniloehbgum s)lrvstrm(unlay,ahiceiso a (tjaelr )dcvrianxeusuaa.c ihtiWn 1 hou.r

acute hemolytic transfusion reaction (AHTR), also called immediate hemolytic transfusion reaction, is a life-threatening reaction to receiving a blood transfusion. AHTRs occur within 24 hours of the transfusion and can be triggered by a few milliliters of blood. The reaction is triggered by pre-formed host antibodies destroying donor red blood cells. AHTR typically occurs when there is an ABO blood group incompatibility, and is most severe when type A donor blood is given to a type O recipient.Antibodies against A and B blood groups (isohemagglutinins) present in the recipient's blood destroy the donor red blood cells.They also activate the coagulation cascade (blood clotting system) via factor XII, which can lead to disseminated intravascular coagulation and kidney damage. Isohemagglutinins also activate the complement cascade via C3a and C5a, which then promote inflammatory cytokine release from white blood cells. These inflammatory cytokines include IL-1, IL-6, IL-8, and TNF-alpha, which cause symptoms of low blood pressure, fever, chest pain, nausea, vomiting, and wheezing

hsTi is uacet yhctlimeo tuinsnfoars eaocntri, I lieeb.ve Type II SRH so ’sesh gofrinm teaodiibns atgaisn het BAO srupog on eth lbood .cells mtnpeCmleo si duinedc by noitas.ibed