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NBME 22 Answers

nbme22/Block 2/Question#42 (23.2 difficulty score)
A 75-year-old woman has taken 12 ...
Plasma renin activityπŸ”
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 +7 
submitted by privwill(22),
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tSep yb Sept:

  1. AIDsNS olbkc dniaolsngstrap cwihh lalynmro ealdti teh fnrafeet eetrloria
  2. toctirinoCns = eacerddse ldboo fwlo to guremlolsu dreaesed(c RFG; crdaeesed PRF)
  3. ecderaeDs lbdoo wfol aesdl ot citaotvain of RAAS msteys
  4. cvAtntoaii fo SRAA aldse to crnedaies rnnie

hyW tno the hrteo os:ne

.A FGR wlil be dedscreea due to osniicnortct fo teh afeeftrn
B. anlRe loobd lfow lwli be esaedecdr edu ot rocoascsntotnivi of teh naereftf
D p;a&m .E cuniooPrtd eklbcdo by SNIAD os udo'lwtn enev eb drnuoa




 +3 
submitted by littletreetrunk(17),
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I ithkn het sniecare in apalms irnne itytavic twhi DsSINA has ot do wtih ihitibonni fo feftneer aerrty niiatdol yb insrdltogpnaas G,E)(2P neisc tthas' tawh sIASDN do by nnhgiiiibt OX.C sTih daeredecs narel loobd wofl sdlae to ASAR inctiavtao ot nvercsoe ewtar nda iumlltetay rnnie aesc.erins

htballer55  Afferent artery dilation* +5  
link981  There is decreased afferent renal artery dilation (less blood flow) leads to increased renin release from the juxtaglomerular cells (located near the afferent artery) to try to increase blood flow. I got it wrong but after reviewing saw my idiotic mistake. +1  



 +2 
submitted by lilamk(10),
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nAy gshuotth uwdol be !elflphu aknsTh s.ineusge

generic_login  I used that reasoning to pick C, but in looking it up now it seems like you are right ... There appear to be a bunch of mistakes on this test, and it’s not giving me a lot of confidence for the real thing. +  
mee48  I think it is because NSAIDs inhibit the local prostaglandin (PGE2) in afferent arteriole β€”-> less AA dilation β€”-> stimulation renin release. I think my reasoning came from sketchy pharm nsaid video but I can’t 100% remember +  
keycompany  NSAIDs constrict the afferent arteriole. ​ A. GFR would decrease due to decreased renal blood flow. B. Renal Blood flow would decrease. C. Renin would increase due to renal hypoperfusion. D & E. PGE2 and TXA would decrease (by MOA of NSAIDs). +9  
fallot4logy  UW says that Nsaids is one o +  
fallot4logy  UW says that Nsaids is one of the 5 drug categories that is able to cause hyperkalemia.Specificly ,Nsaids lower PG andrenin secretion .PGE2 stimulates JG cells to secrete renin...(how can i delete my previous unfinished message,lol?) +1