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NBME 24 Answers

nbme24/Block 1/Question#11 (43.5 difficulty score)
A 55-year-old man with type 1 diabetes ...
Persistent activation of voltage-gated Na+ channels in the nociceptor🔍
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 +15  upvote downvote
submitted by njspix(15),
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rPe p,TtoDeaU eth yke hree is the diay.llano Tihs panitet hsa tactni nsten,oais t'si ujts dn"true "up awy oto uchm. Teh elimstps ayw to eixnalp isth si taht the snerso etfils hte( o)cirtocpen si tod.vearcei-tav

otNe hatt vpcneoctiei iapn sa( htis si tdre)me si mreo efnot due ot uasa/iismpeninsoesmt/tlrerfu ea,mgda seehwar cpuehnrtiao pnia emr(o trcanl)e has a ewdi yirvtae fo usaesc btd(iesea si a entipnomr e).no




 +11  upvote downvote
submitted by seagull(1109),
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hnrtoAe a.achrpop stebeaiD sscuea ezync-naotinm soyalyntoiglc icwhh mya etniyvaegl aiptmc eht nofitcnu of runseon nlimya ued ot telerda dobol usylpp nmgao thore ints.gh hseeT otsylglcyea ssidetop tyclaiypl rcocu hrieplryepal ta hte gl.se ehT onyl rphierpael wnrsae ehcioc asw a iopteoccnr in het .lesg lal the rtohe anesrw coecsih are ta astel mreo yarceltnl acetold thiw agrrle dbool sp.uepils

iAg,na ont eefrtpc utb a yaw to sronae otu isth ensraw tbu it dseo rk.ow

sam1  I believe this concept is referring to peripheral sensitization. Peripheral nerves that have sustained damage (such as through non-enzymatic glycosylation in DM) cause sensitization of their neighboring nerves, thus leading to lower thresholds for activation. This sensitization is thought to be accomplished through mediators such as PGE2. +4  
sam1  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701208/ ^ Section on peripheral sensitization +1  



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oiAdylnal is ctrnlea apin tszoiinasen.it nirTrigegg of apni by a onn iapufln iut.imls solA ense in asFo i.blvymra[gi eaaHsrilepgy : cnI spseeron to pilfnau liiu]tsm

Its a tsioevpi (ei. ceilAtyv n,egelfi ont lkca of e)ieflng t.ymsmpsp so B ;m&ap C si otn the nr sawe.D sitn nawsre ie.ehrt as idavnliol erctoper T)R(1VP is saol etfeafrn ecitnceopiv strnniasoism ou(mteldad yb p)aacs.iicn votictnaiA is oson oolfdlew by .etisnizateodnis

A - .KDI if roebpml swa ni RGD htree odulw eb tol ermo tmsosmy.p

madojo  if you are an idiot like me than that long word in option b is GABA +3