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nbme24/Block 2/Question#46

In a study of drug action on neoplastic cells in ...


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submitted by daddyyikes(2),

it wasz the the shittiest question that i have ever read in my entire life ever!

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submitted by m-ice(123),

Vincristine is a chemotherapeutic drug that stabilizes microtubules and prevents them from disassembling. The cell in the picture is stuck in anaphase, with microtubules attached to its chromosomes, unable to pull them apart because it cannot disassemble its microtubules.

vshummy  So I get that by process of elimination cyclophosphamide, cyclosporine, doxorubicin, and 5-fluorouracil are not related to microtubules but vincristine in First Aid 2019 says it prevents microtubule formation, doesn’t stabilize it because the one that stabilizes microtubules is paclitaxel. +  
vshummy  Okay, I realize now- the picture is stuck in metaphase, not anaphase. Both paclitaxel and vincristine stop the cell in metaphase but by two different mechanisms. Vincristine prevents mitotic *spindle* formation while paclitaxel prevents mitotic spindle *breakdown*. Mitotic spindle is needed to pull the chromosomes apart before anaphase begins. +6