welcome redditors!to snoo-finity ... and beyond!

NBME 24 Answers

nbme24/Block 3/Question#29

Drug X is given to a 25-year-old normal subject. ...

Partial agonist at β-adrenergic receptors

Login to comment/vote.

 +8  upvote downvote
submitted by tea-cats-biscuits(69),

Partial agonists have weak agonist activity on their own (thus in this case it causes HR to increase, b-adrenergic effect) but when an actual agonist is present (aka when you are exercising, you are producing NE and E that have full b-agonist effects), partial agonist actually have a mild antagonist effect (thus the heart rate decreases).

potentialdoctor1  Might be relevant to add that there are two beta-blockers that are actually partial beta-agonists (exert their blocking effects due to lesser effect when compared with endogenous catecholamines) ----> Pindolol and acebutolol +