NBME 22 Alveolar macrophage (NBME Answers)

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Retired NBME 22 Answers

nbme22/Block 4/Question#3 (reveal difficulty score)
A 60-year-old man comes to the physician ...
Alveolar macrophage 🔍 / 📺 / 🌳 / 📖
tags: pulm repeat

+13 upvote downvote
submitted by ∗welpdedelp(270)

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It was a Ferruginous bodies--> asbestosis. Ferruginous bodies are believed to be formed by macrophages that have phagocytosed and attempted to digest the fibers.

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almondbreeze info about ferruginous bodies being mf can't be found on FA/UW :'( they just say it's 'material' +

taediggity FA 2020 677, FA 2019 659... mf?? mofos?? +3

69_nbme_420 Just to add: The question asks what cell type initiated the Fibrosis → Alveolar macrophages engulf the particles and induce fibrosis (same pathophys for all Pneumoconiosis). Pathoma 2019 Pg 92 +10

alexv0815 "A small (< 3 μm), golden-brown, dumbbell-shaped particle that contains iron. Most often seen in the alveolar septum in conditions such as asbestosis." amboss +

@69_nbme_420 explanation is more correct. Adding it for visibility.

The question asks what cell type initiated the Fibrosis → Alveolar macrophages engulf the particles and induce fibrosis (same pathophys for all Pneumoconiosis). Pathoma 2019 Pg 92

+2/- b1ackcoffee(115)

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submitted by ∗syoung07(58)

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Pneumoconioses get allllll the way down to our alveoli to cause fibrosis and thus restrictive lung dz. Alveoli dont have the mucociliary elevator to clear shit so they depend on macrophages to get rid of substances.

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