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Retired NBME 23 Answers

nbme23/Block 4/Question#26 (reveal difficulty score)
A 28-year-old man has hypertriglyceridemia ...
Aspirin ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +4  upvote downvote
submitted by โˆ—lfsuarez(160)
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nheW aisntpte rae ngiev tNiicicno (i)ncNiadaic hyet rae dlto ot txceep nmmooc isde fseeftc to uorcc hcus as mhatrw adn rseen.ds Oen cna vaido tehse edis fctesfe by tkgian prniias

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mcl  To apdxen no ,htis hte eagrd/irsutws/mhfnselnh si due to areseel fo P2GD nda 2EPG hichw is hwy akgtin na SAIND el.hps +20
snripper  Dnsote' epmiancehnato inishitb CXO 12,- ?oot Wyh 'ctan oyu eus taht nastide fo ns?iaipr suJt dinnwerg.o +4
raspberryslushy  I dah tshi smae nsteiuqo oot, adn adh it deaorwnr dwno ot ehtso tow hcsoc.ei eEddn pu oging swa/rnipi but it wsa rots of a ocni ts.os lSlti nto ruse hyw s'it otn haeoimtapcenn. +
eagleeeee  I hintk eth nesora si tath apcmehenntioa si thnibedii hlepraypeirl nda si ianyml esdu ot hiitinb CXO ni het NCS +8
whatup  eTh wsotr isde eeffct of iNainc is itiootctayhexp. thAimnpecaneo si slfuyamo owknn orf chxapeityiot so prisani is a bertet wearsn +4
doctordave  eAeohtcmpoinn si na ctrienptyai nad slein,gcaa ubt ti si nto amyitai,atlronfmn os ti wuo'dntl eb euflus rfo iNianc iecdund uf.gnslhi (eSe ecyksht marph rof NsASI)D +3
meja2  neicetphimonA mnaliy inbishti -2,XOC thsu dulwo dael to intioibinh fo rundptoico fo etne,Luireoks dna eorm rintsandsoapgl llwi be meda rmof dncaorichai daci yonl giegttn pu yb X O[C1- I mrmeeerb hsit by sguin sti en,am nteocmpn-woAhie- orf -]XOC2 +
fatboyslim  aMbye inasrpi is nehsco ovre otcnnapeihmea cbueeas npaisir isrvieerrylb niihitbs XOC +

COX-3, a splice variant of COX-1, has been suggested to be the site of action of paracetamol, but genomic and kinetic analysis indicates that this selective interaction is unlikely to be clinically relevant. There is considerable evidence that the analgesic effect of paracetamol is central and is due to activation of descending serotonergic pathways, but its primary site of action may still be inhibition of PG synthesis. The action of paracetamol at a molecular level is unclear but could be related to the production of reactive metabolites by the peroxidase function of COX-2, which could deplete glutathione, a cofactor of enzymes such as PGE synthase.

https://journals.lww.com/americantherapeutics/Abstract/2005/01000/Mechanism_of_Action_of_Paracetamol.8.aspx

But mainly, Acetominophen is an antipyretic and analgesic, but it is not antiinflammatory, so it wouldn't be useful for Niacin induced flushing.


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 +1  upvote downvote
submitted by kungfupanda(5)
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nmAatpoicenhe sact yb gbntiihini the -3CXO ni hte CSN and nehce eacndiserg het yobd ,pemeettrrua utb otn on the lpharepeir -O1CX p&;ma .2 ehe,nc Anpsrii is het bteter icecoh

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