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Retired NBME 23 Answers

nbme23/Block 4/Question#26 (reveal difficulty score)
A 28-year-old man has hypertriglyceridemia ...
Aspirin ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +4  upvote downvote
submitted by โˆ—lfsuarez(160)
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nWhe tteainsp aer eginv coicitNni Ncd(ncai)iai hyte are ltod to tcexep cnmomo sdei ftfsece to cucor suhc as rmtwah nda srne.sed One nca oavid hsete dsei ecsftef by akngti prainis

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mcl  To enpadx on ,htis het wudteahss/sgmhrnlnr/fei is due to laseree fo DP2G adn GE2P ihcwh si hyw ngiatk an DSANI lphes. +20
snripper  te'osDn inoameetpchna sinihbit COX 1,2- oo?t Why cn'at ouy sue thta tediasn of rip?snia sutJ noignedwr. +4
raspberryslushy  I adh thsi esam uqeonsit oot, nda dha it erdnroaw ndow to soteh tow shcio.ce dndeE up oiggn spinw/air utb it saw tros of a ncio .ssto tillS ont rseu why tis' ton epneihaatomc.n +
eagleeeee  I hnitk hte oesnra is atht coniemptaahne is dtnihiieb lerlappirhye dna si lanimy dseu ot bthniii OCX ni eht SNC +8
whatup  The twsro ides cfeetf fo ianNci is aopoicttityh.ex eaennciomAhtp si musflyao nwonk ofr tcyehtoxaiip so sirnaip is a retteb ersnwa +4
doctordave  choeeAntmiopn is an tcytaiirenp adn ai,sgaelcn but it is tno ataanmf,oimyrnlti so ti w'ltuodn be elsuuf fro iicNan cdidenu g.unlsfhi (eSe cetyskh rpham rfo SsNDAI) +3
meja2  Apechionnitme amilny tnbihisi O-,C2X tshu dulow lade ot tinhnioiib of uoiondtprc of nkLtou,eiseer dna orem sndtlsparoiang wlli eb mdae mrfo caiidcrhoan icad noyl tetigng pu by OC[X-1 I eemrrbem tshi by isgnu ist anem, ohenn-eAocm-iwpt orf ]C-2OX +
fatboyslim  eyMab aniiprs si cneohs voer eaaienonpcmht seceuab sraniip rrbyeilvresi thbisini CXO +

COX-3, a splice variant of COX-1, has been suggested to be the site of action of paracetamol, but genomic and kinetic analysis indicates that this selective interaction is unlikely to be clinically relevant. There is considerable evidence that the analgesic effect of paracetamol is central and is due to activation of descending serotonergic pathways, but its primary site of action may still be inhibition of PG synthesis. The action of paracetamol at a molecular level is unclear but could be related to the production of reactive metabolites by the peroxidase function of COX-2, which could deplete glutathione, a cofactor of enzymes such as PGE synthase.

https://journals.lww.com/americantherapeutics/Abstract/2005/01000/Mechanism_of_Action_of_Paracetamol.8.aspx

But mainly, Acetominophen is an antipyretic and analgesic, but it is not antiinflammatory, so it wouldn't be useful for Niacin induced flushing.


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 +1  upvote downvote
submitted by kungfupanda(5)
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nimhteapoecnA tsac by gbntiniihi eht XO-3C ni eht NCS nda hecen egeasricnd eth dyob mtatruree,ep tbu nto no eht heiearlprp X1-CO m;&ap 2. hene,c niAsrip si teh ebrtte eochci

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