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imnotarobotbut
How is one supposed to know this before having read this article?
+37
imgdoc
This question falls under the either you know it or you dont category. It isnt in FA or Uworld
+2
jaxx
So why would these A-holes put it on there as if prepping for this exam isn't stressful enough :-|
+9
usmlecrasher
and there's so much unnecessarily BS instead of real questions
+3
j44n
I'm just glad we're seeing this garbage now instead of having an aneurysm in the prometric center
+9
feanor
This Question is a perfect example of where you just jump off your seat to demand a refund or you decide to go Antisocial Disorder on your computer screen.
+
olddoc
I don't think it has to do with any extra info. The dx is FAP (mutation in APC gene) which is inherited in an AUTOSOMAL DOMINANT fashion ("A" is the mutant allele and "a" is the normal one. The girl in the question stem MUST be heterozygote "Aa", getting the mutant "A" from her sick father and "a" from her healthy mother. Assuming she marries a healthy husband (aa) (this is a normal assumption in genetics questions), their kid will be Aa (the phenotype that will 100% result in CRC) by a probability of 50%. Recall that FAP will 100% progress to CRC is not prophylactically removed.
+5
conniea168
It sucks because in psychiatry rotation as MS3 you may come across this fact that rate is ~50% in identical twins, but other than that it's unfair for Step 1 :/
+
jaxx
Meanwhile, I thought everything was wrong so I went with another Mature defense mechanism.
+17
happyhib_
What if, just what if. Her taking time to do lessions was actually hurting her children by her having less time to spend with them and in turn not providing good care for them. (less of a mature defense mech now).
Trust me I agree completely just not best answer, but given what we are given you could argue beyond that; amboss even says "a mom showing her feelings of anger towards the child instead of the actual problem, the husband". So in a way she is not addressing her actual problem (which she COULD address).
+1
madamestep
I like to think of Sublimation as Regina George at the end of Mean Girls thriving at field hockey.
+1
d_holles
lol i thought it was some kind of urinary retention problem and put H.
+17
sbryant6
How is H wrong? Oxybutinin or tolterodine treat urinary incontinence by blocking M3 muscarinic acetylcholine receptors --> urinary retention. We're just supposed to assume they are talking about BPH here because he is old?
+1
jaxx
I agree. I picked "H" for that same logic. Does anyone know where we should have come to the conclusion that this was BPH?
+
forerofore
they are telling you he's having "difficulty urinating", one of the clinical criteria for BPH is reduced urinary flow rate. this is not incontinence because they are not telling you he leaks at all, just that he pees "a lot"
+13
drzed
Even if he was urinating too much, anticholinergics are contraindicated in the elderly (Beers criteria)
+7
pathogen7
@drzed tI mean techinically alpha-1 blockers are on the Criteria too ...
+2
ht3
you're definitely not alone lol
+
yotsubato
And its not in FA, so fuck it IMO
+1
link981
I guessed it because the names sounded similar :D
+18
yb_26
I also guessed because both words start with "glu")))
+30
impostersyndromel1000
same as person above me. also bc arginine carbamoyl phosphate and nag are all related through urea cycle.
+1
jaxx
Not a clue. This was so random.
+
mkreamy
this made me feel a lot better.
also, no fucking clue
+1
amirmullick3
My immediate thought after reading this was "why would i know this and how does this make me a better doctor?"
+10
mrglass
Generally speaking Glutamine is often used to aminate things. Think brain nitrogen metabolism. You know that F-6-P isn't an amine, and that Glucosamine is, so Glutamine isn't an unrealistic guess.
+6
taediggity
I literally shouted wtf in quiet library at this question.
+2
bend_nbme_over
Lol def didn't know it. Looks like I'm not going to be a competent doctor because I don't know the hexosamine pathway lol
+25
drschmoctor
Is it biochemistry? Then I do not know it.
+5
jesusisking
I Ctrl+F'd glucosamine in FA and it's not even there lol
+
batmane
i definitely guessed, for some reason got it down to arginine and glutamine
+3
baja_blast
Narrowed it down to Arginine and Glutamine figuring the Nitrogen would have to come from one of these two but of course I picked the wrong one. Classic.
+2
feeeeeever
Ahhh yes the classic Glucosamine from fructose 6-phosphate question....Missed this question harder than the Misoprostol missed swing
+1
schep
no idea. i could only safely eliminate carbamoyl phosphate because that's urea cycle
+
flvent2120
Lol I didn't either. I think this is just critical thinking though. The amine has to come from somewhere. Glutamine/glutamate is known to transfer amines at the least
+1
While the lifetime risk in the general population is just below 1%, it is 6.5% in first-degree relatives of patients and it rises to more than 40% in monozygotic twins of affected people. Analyzing classic studies of the genetics of schizophrenia done as early as in 1930s, Fischer concludes that a concordance rate for psychosis of about 50% in monozygotic twins seems to be a realistic estimate, which is significantly higher than that in dizygotic twins of about 10โ19% (ncbi.nlm.nih.gov/pmc/articles/PMC4623659/#ref3)