NBME 21 Nuclear/cytoplasmic shuttling: yes;<br />Serine phosphorylation: yes<br />Ubiquitin-mediated proteolysis: no (NBME Answers)

NBME 21 Answers

nbme21/Block 4/Question#4 (reveal difficulty score)
The FOXO transcription factor responds to ...
Nuclear/cytoplasmic shuttling: yes;
Serine phosphorylation: yes
Ubiquitin-mediated proteolysis: no 🔍 / 📺 / 🌳 / 📖
tags: biochem

+13 upvote downvote
submitted by calcium196(12)

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adU-itnuibqetiedmi osiyertpols si ont iyreesvrbl etaffced yb .sunnili Teh uotseinq ksas for bleersrvie swya ahtt ilnsiun fctseaf i,t adn naiqnuuiitboti olduw lead to irgtdeaadon avi ,erstoepas hihcw si ton vrseerble.i ryotaellmacsuccp/Ni uhsngtin skmea sseen ebausec OOXF is a trsiitrnpoacn t,frcoa os ti ct’an do sit ojb fi it is ni the cmsyop!lta

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meningitis nTakh yuo orf ouyr npanl!iteoxa Oe n i:qesnuot owH buoat the reenis isnlhyaopptr?hoo Is ti dweeanrs by prue otizmnmoaier atht het OXFO FT si seerin ,ldyseoohrappth ro is ti a elrngae ctfa ttha lla s'FT era ierietnnr-sonhee psdpaleyho?roth +

tsl19 Im' ton ,resu btu it mya be as mpisle sa ts:hi mibtadiieidquen-tu poytsrseiol is irbsrervelei, utb ohtb /NC iuhttlnsg nda plrohoosahpyitn era nyrlgaeel ivlbeserer s.essecopr +

didelphus I also ussdege thta OOXF tsmu be a aprt fo eht 3KIP wyah,atp csine nuslini gerlsueta masmlobeti htrohgu 3IPK dna eht sontqeiu mets selclfpyiica mstinnoe ta.ht Ponylaihrhptoso si a amrjo rtpa of ttah phwata,y os even rnctldiyei lrotianhoyshppo lwodu ugaterle FOO.X trgtFirusan qnet.iosu +21

niboonsh y,es FOOX si dfaeftec nmtsraweod fo het tioactnvai of .KPI3 Tshi is a lelrya dgoo evido htta saxnpeli the elwho ascadce .syc/u9twe-/pLguNha/=towwvobe?:dwmtct4shw.3 +2

alexb giAodnccr ot ikaipwide (:a/iXw1kp//hOOg.eswtpiieokd/tFirn.i) shhypaiootrlnop fo FOX1O is .elvirrsireeb ihTs is rrnigfere to osopitphrhloayn of senire dusiesre on OOXF yb kAt, hcihw rcucos in eensorps ot .linnsiu Btu eht NEMB eanrsw ssgguste tis' e.rvreisleb h'aWst p?u +2

almondbreeze olcdu iwik be ownrg no rphynootpasholi bngei selb?everirir ccogdrain to shti cla,itre ti si a ireervselb es:cpsro gutiaoerln fo OFox niapstticrnor faortcs by eeilebvsrr htlanoyhospiopr nda coitanteyla (i/eeipi64e3r0mo70isadccs8n5.0wcp1:ss10c/lh0cr1wt8tceS/0/ii//7#ctt0we9.n1eso) me iwki nf,io roev,weh si pluelhf : nI sti hp-uhasoetyplrndo se,tta FOOX1 is clzdilaeo ot the nusuc,le where it nibds ot eth lninisu repseson eesceqnu dcltaoe in teh ormoretp for sluogce p6epahtsasoh- dan irscaeesn ist rtae fo niprsor.natict ,X1OFO rhgthou egirinnsca strcnoriatnpi of ohusla,eeptg-hoc6pa-ss cdrlitniey escaresin hte aetr of aicehpt celsgou 9].cdruonp[ito1 v,erowHe wehn OF1OX is optyphldaerhso yb kAt no ,2h4-rT S-,52r6e dan 31r,e-S9 it is ueeddlxc rfmo the c,uuelns where it is thne iiuidanquettb adn ddageedr. hTe onyoosphhirtalp of OXF1O by kAt qsulybseentu essareced the icpetah ouslecg rpnouoitcd hhgturo a decaseer ni ptrtnnciisora of gelsouc sph-sphoae.at6 +

leaf_house It essme ekli eth tnypaoorslhohpi mrof kAt leads ot ,udrteotnsci ubt beamy eht naoimtupss is that ttah loitnphrhsoyopa tspe n(eilcugxd veery hoert ptse fo eb-uprsotmiiqioetnou at)phyaw si evlere,rbsi wrehe oetsypsiorl is lin.af bs nio@noh ioedv si dogo ubt edtons' pitsl siht eno. +

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submitted by ∗imgdoc(183)

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ishT eqtuison is agnksi otaub eht nilsuni oprcrtee rotesniy nsekia waay.pth So take it mrof hreet,

The yrhnsaoptphoilo of hte RIS esiattvca a lgaisn nncrsudttaoi accsaed tath sdale to teh naioctviat fo oreht snaieks as ewll sa tarrinsinpcto fscorat thta meeidta het eliatnularrcl fteefcs fo n.suniil lrpuitoccs/lyCaName gtihstunl - eys )vbreslrei(e
enneSineeirohr/T kaeissn are loas konnw to deuecr het ytaviict of sinnli.u - sey rel(esbie)rv
iqiitnuUb - tiddaeme oslipoyesrt - on ot(n rer,iesev)lb dan alos sinilnu iblmaeoyctlal senrcsaie ptorein isnyhsest so it t'ensdo cmhat wtha islunin does aasyyw.n

rcroect me if Im' r.gnwo

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usmle11a i htkin oyuer rtcoecr aeusc qniuuibit etdmdeia poeorytlis is na ereilivrbers .espt +1

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submitted by ∗hello(429)

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The Q esmt sasett FOXO is a ptoacinsirrnt tarfco hatt snresodp ot inilnus aggisinnl by taielgnr het ncaiotsipntrr of tiaclmoeb nsege t;-&g- rf,eoereht XOFO is a coisnpintrtar frtaco olenvdiv in om.ilasmetb hTsi shudol aemk enses aucbsee n-trpsrluieienoc nttciiaavo hsa a elro ni lnrgugtaie i.esmambtol

Thsi Q saks bauot resvirlbee ways htat uinlnis esrageut OOXF narstrotcnip otacrf yaiivctt.

aieimtntiUbqid-ude yelpostrsoi is eirerbsverli. eltinEiam all oichesc pecetx for B, D, nad H.

rprennoseslct-uiI ucitofnn ghhtoru 3PIK giigasn.nl 3IKP gasngniil ovvsilen topiyhsoplorhan of neirse ;t-&-g eserin ahplortyonihops is a vlerreiebs sre.csop ialiEntme .H I:YF r/pimntaeinoo adic onpalhtisoyphro is saaywl r.vbielrsee

uoY rea tlfe ithw hieocsc B and D.

FXOO si a csirrnotiaptn coftar &-tg-; riittcpronsan rtafcso etiaemd eegn iatytvci yb tslunithg nweetbe teh scptayolm and lnucsue. guniRtglae het ancitloo fo XFOO asrrinitcntop ocrfat ei.(. taplycoms v.s euu)ncls iwll ohefrtree ysrrebleiv moldueat dmXdiOae-tFeO leaibctmo eeng iitt.acyv

hisT avseel oyu with het octercr :ewrnsa ciCeoh B.

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adong A tertbe ywa to nhikt uabot ti si usiniln acst gotuhhr KPMA whcih is a tnsrieoieeehnrn/ ineksa +1

amy I dtpretenaite atmiocuypcllas/rCeN tghntsuil wlodu be eth ertsul of isreen rpph,iyootahnlos os eth eserervbli ciaiitonfomd si noyl no eienrs ryash,ipholonpto ihwch ldae ot sclen/ipcyctaaolurm guinhttls, utb het thslntuig fltise is nto erudn m.da oonfIcitii ogt ti gron.w +

+1 upvote downvote
submitted by ∗usmleuser007(464)

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Sniree orlhyophisaptno llwi ecdreu ninlusis' afe.stfc tI cats on teh ensoytir aknis.e

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alexandramda .g7el/d028.oto)l.-w0/(lS0w-9rbsh8yt3nc6tcc09w:/9rpu0/fo2f/i-pem0dp +

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