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Retired NBME 21 Answers

nbme21/Block 4/Question#4 (reveal difficulty score)
The FOXO transcription factor responds to ...
Nuclear/cytoplasmic shuttling: yes;
Serine phosphorylation: yes
Ubiquitin-mediated proteolysis: no ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: biochem

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 +13  upvote downvote
submitted by calcium196(12)
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iuediq-itemniabUtd ipslyrtseoo is ton sbirryveel cedteaff by .silunni ehT tsqonuie kass ofr eeverirlbs wsya atht inlnsiu cfeftsa ti, dan itiitqbuaunnoi ludwo elad ot giatdeanrod avi teoapesr,s hhcwi si nto rreebe.visl yic/uaNtclocpalserm iutnnsgh esmak neess ebeacus XFOO is a itcrnsonritap aofcr,t os ti โ€™cant do its job if it si in eht y!pcoltams

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meningitis  hanTk yuo rfo oryu aelpntio!anx nO e sq:inueot wHo tuoba hte enesri opotsh?ryinhplao sI it eawdnrse by upre roeiommzitan that the XOOF TF is nseier hoesta,opypdrlh or is ti a lneerga tcfa tath all s'FT are heseini-rrnneeto hetpldaysoohr?p +
tsl19  mI' nto erus, utb it yma eb as mleips as thi:s du-miaidetnbqietui elirpooysts si r,erbievrsile ubt obht C/N uhlsngitt and apilrstohonyohp era eaylnlgre viesberler c.sspeoser +
didelphus  I lsoa dsgseue htta XFOO tusm be a atrp of hte 3KPI ,awhatyp sneic lniisnu ureltegas motselbima ghortuh KP3I and het setoiqnu mste syfcieacplil tosennim tat.h alpoiPsotorhnhy si a amrjo trpa of thta aphwty,a os neve ycnitilrde athopoysilopnrh odwul tueaergl FOO.X ttnFgsauirr tioqe.sun +21
niboonsh  ,yse OXOF is dfcteeaf owatnerdms fo het oaaittcivn fo K3P.I iThs is a erayll odgo viode ttha nipxseal eth hlwoe dccaeas a9-tNs=wov/ouw?eh4/wsum.bwtc:hwL.tdyt3ce/pg +2
alexb  rgcnodAic ot aiwpikide (tXirdOanphF/Ok1s/pokiiw/we.ig:i/.te) oisrohyoptpahnl fo XO1FO si lberre.rsevii hiTs si gefnrrrei to hliypatohosprno fo eserni esdsrieu no OFOX yb k,At cwhhi rscocu in sserpone ot niils.un tBu teh MENB ranews gsgssetu si't rvbil.seeer a'Wsth up? +2
almondbreeze  doucl iwki eb wnrog on ptnrpaoihoyhols begin beverrsreil?i ndciagrco ot shit rl,aiect ti is a serblrieev ro:cssep ilgatruoen of xOFo sonitcpnaritr atforsc yb ilveberers hoohsyolpntirap adn tiaeaoylcnt (l.ewiic9o//0mse01:6c8cS01#tware70n/dcee0rp43c7/t8thist0i5pi.e/10cisn1s/wc o)mse iikw fino, oew,ehrv si ulelpfh : In ist eho-pnyhsrldaptuo tt,esa O1FOX si lcladoezi ot teh e,ulucsn eewrh ti dsibn to the sniunli essopner sqeneceu lodetca ni het ermropto rfo secguol ap6hh-pseaots nda icasnseer its rate of atcnnost.ipirr O,FO1X rgutohh aegniirncs incantirrtosp of ho,tasas6pp-oelu-echsg tdcinyelri nrscaeeis eht etra of eacipth scegulo opnro9d.[ict1u] o,ewevrH wnhe OXF1O si hoprathdpoyels by kAt no hrT2,-4 e5-6r,2S adn 91-Se,r3 ti si lcedudex rfom teh n,culesu rehew ti si nthe ntqidbiuatieu nda darg.deed The ryaoplohhontpis fo FOX1O by tAk ulyuqenstsbe rsscedaee the theacpi ueglosc rcnupdooit rohtuhg a cedersae ni cnnasroipitrt of elgoucs .hs-thpapaeso6 +
leaf_house  tI meess eikl eht hnsthoiyoprapol rofm ktA dalse ot teunts,icrdo but eabym het pontsumais si atth hatt nrotyshalppioho sept (xudleincg revye hreto pste fo tiooumitqnpu-sebroie ya)tahwp is s,breeleriv wereh systrlopeoi is nail.f h@ iobsnno oiedv si dgoo but d'osnte ptsli hsti oe.n +


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 +11  upvote downvote
submitted by โˆ—imgdoc(183)
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ihsT qsuotein si ignaks toaub het lniusni optrreec instoeyr iakens wahypta. oS aekt ti morf etrhe,

  1. eTh ilnohtoyaphpors of eht IRS ttasievac a nglasi trtnundiasoc accedsa ahtt adels to hte voaiatncti of rtoeh ksaiens sa lwle sa aincornittrsp rsoatfc taht aimteed het uantireclalrl ffteesc of ninisu.l lapCltmsy/uoceNriac uslntight - yse e(evli)srrbe

  2. einneoereni/SrhT seskina are lsoa nonwk ot udecer hte ayvittci fo iiln.sun - yse ri)eveslber(

  3. uqiiitUbn - idmetdae isoosytelrp - no tn(o bireveersl), nda laos innilus lmolbaeaytlic ncsseaeir eiotprn hytsseins os ti 'osnted camht what suninil deso aynwsa.y

rrotcce me if 'mI or.gwn

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usmle11a  i nhikt uryoe crercot seuca qiuitnbui tdeeamdi yeoloirstp is an eriblesivrre sp.te +1


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 +7  upvote downvote
submitted by โˆ—hello(429)
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The Q mset easstt FOOX is a npnitocratsri acotfr ttha drnepsos to ilsnnui igslangni by aegnltri het srninracpotti fo cmbaitelo geesn ;g&t-- refr,teeho OXFO is a tpnroiacrtins rfacot oilevdnv ni ioslbamme.t hsTi sluodh kema snees uesbeac li-rstnpucnoeire ontavicati has a oelr ni atgugienrl olmtb.emsia

Tish Q asks oubta blervierse syaw thta isnnliu ruetsgae OXOF nrpcarnttios rcfaot ictiva.ty

dUbiqemiudi-tneati tlsoioeprys si rebieersirvl. Emlintiea all ihsceoc pxteec fro B, D, nda H.

rut-slinseerocpnI oinftucn ugrthoh P3IK snni.iglga 3IKP inalggsni evisovln yaphsiprnoltoho fo irsnee --;&tg neseir nosrotlypiahohp si a ileveersbr c.osersp ilinteaEm .H YIF: tima/oennorip acid ophtrhysanolpio is asaylw s.eievrbler

uYo ear tlfe hwti siehcco B nda D.

FOXO si a rinstncapitro aocfrt &;-t-g ocrnntiarstip acortsf iedatme eeng iicytvat yb stguhntli netbwee eht ytspcalmo and ne.slucu iluetggnaR eht otoclnai of FOOX nirtncpasitro aftroc (..ei cpmylotsa vs. ulncs)ue lwil rofhetree bivyerlers luodmeta -ddetaieXmOOF blteicmao neeg cyitt.aiv

Thsi eevsal uoy whit het ceortrc nra:esw Cocehi B.

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adong  A trbeet ywa to kinht outab ti si uisinln csat tohrhgu AMKP wchih is a irhoeetnn/snerie inkeas +1
amy  I iadetentprte eymu/aCclprtNciasol lsiugttnh wodul eb hte eltrsu of erseni oroaisopphlyhtn, os het sielerrvbe ocitmnaiofdi si nlyo on rneeis hyli,rhppsootnoa hchwi edla ot ple/cnltriyaomsucca slguihntt, tbu eth snuittglh tfseil si not rdeun diaIi.tcmofno i ogt it g.nwro +


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 +1  upvote downvote
submitted by โˆ—usmleuser007(464)
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iSnere poirlnhtashpoyo lwil edruec sunsni'li efc.atfs It tcsa no eht syeintro ae.nisk

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alexandramda  fgrbt.cfo39p0y8to)0l7089wlcr:0/w0mdnh/.c29w./ipo0sS-//(2-lte6ud-ep +


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