heT slnaiasy noyl wdoseh a ainumtot ni neo le.alel FC is an solutomaa eisvrcsee ed:sieas het daessie noyl ntameissf if reeht aer iuomttsna in boht alsllee fo eht FTCR e.neg

If uyo tslil ehav 1 lntnfiaocu pyco of het CFTR eg,en yuo anc lilts kema hte RFCT inrtpeo h(et lheoircd /)aratnnetsr,pcorelhn ecenh yuor odby ’ntwo vahe nya use.ssi

Tihs is ougoansal to uortm sropssreup genes klei Rb: os lgno as neo fo the llsaeel ouy ehva si outialnfcn, uoy nca eakm onuehg of het irnoetp to mak“e ”up ofr eht dictefvee llae.le If otbh egt kendcok tou R-,)/-b( yuo sole hte etiortcpno deivropd yb eht eeng aesucbe wno oyu ekam on pneoirt at lal.

eTh lyno ginth that emda nssee ofr tshi tuioqsen saw het tcaf hatt hte hoert eallle aws ton udenilcd in het sylnsaai.

ELLACIL EEHTGITREEOYN F(A peag 75 091)2

rsehTe liputeml lellea atirvsan fro hte TFRC eeng in a enlgsi scuo,l so ouy ulocd tge syccti irfisosb mrfo a titonuma in nay one of soeht aellel t(nerirahasstve over 0501 ifnfetrde tiaoumsnt deri)sbecd eth qtoneuis smet netmdneoi yhet tdsete rof hte mots momcon ,tysep so ew acn sasmue thye yolbprab sutj esidms ttseign for aosnmtuti in reoht el.selal

TIR is smraedeu ni noirtue elkhrpci-e odobl atekn ofr aeccbioilmh esrginnce of lla rbnoenw ftsnain ornb in the UK. siTh etst si oen fo a benrum of doltpceem ni rnbewno eicnengsr t(he "ruGieth sTt.)"e In urtsiaAla it si onwkn 9%4 of etosh ihtw lvtuenea ogdsiinas fo FC avhe a oeisvpti TRI on nwobern er.secn laeSmps whit a sdeiar IRT en(fdide sa htisegh 1% of aesv)lu rae nhte eedesrcn for ommonc CF eneg umo.taitsn ahEc nrtcee sah a lsyitlhg eirfftden eegn pnel;a teluynrcr 5-040 of het mtos omcmon enseg are c.qnuesede wvoe,eHr hrtee are remo than 0200 wnokn ottni,amsu so eegn aenpl eisnttg edso ssim sinoloaacc FC itanetsp

fI ngee eigntts dinsf neo tuoantim htye llwi hent aveh a stwea ttes to phel mconfir teh .isagdnois aStew getinst si meor klyile ot eb eauvlcqio in anitsnf dan ylpliatcy tno edptmttae ni thsoe under 5gk. fI wstae tets is esioivpt rmoe aieepxvns eeng intetgs si iens.ocddre fI two namotsuti are ofund yeht are odgniesad htiw .FC

SLME.IP 3 t.ssep

1. ew kwon htis girl ash icysct bsiiorsf .

2. tub nstigte wsosh ylno 1 ellael is uettdma.

3. cnies esh hsa ,FC eht hrote leelal ONANCT be romlan , dna the yoln aotxpinlane ot hre nvahgi FC is hte alpen idtnd eettdc i.t

oyu dene a aotnmiut ni 2 ellelsa to get FC ces[in it si taooamsul ee/sriecv]s

Ahenort t.ng.h.i I'nts ti esslpboi ttha hbto hte sawte ecrliodh stte dna the memiecratiuonv sntirpy rea ujts alsef +? hBot of steeh etsts veah pyrtet owl rsoetlhdh fro rnitegrun as a + pnss.oree Wyh a'tcn ti be lesbipso hatt noe iclleal toianmtu si nuogeh ot ueacs a tsvpioei esulrt ni heets ste,ts wtoihtu alatcuyl fyisggnini teh tp sah a ?asiseed yM ylon uegss is taht censi two raesnws itdinace ahtt hrtee duclo eb a felsa iitsopev, hnetire acn eb the trhgi erswan.