NBME 21 Nuclear/cytoplasmic shuttling: yes;<br />Serine phosphorylation: yes<br />Ubiquitin-mediated proteolysis: no (NBME Answers)

Retired NBME 21 Answers

nbme21/Block 4/Question#4 (reveal difficulty score)
The FOXO transcription factor responds to ...
Nuclear/cytoplasmic shuttling: yes;
Serine phosphorylation: yes
Ubiquitin-mediated proteolysis: no 🔍 / 📺 / 🌳 / 📖
tags: biochem

+13 upvote downvote
submitted by calcium196(12)

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qUdmdiitneeu-bitia persitooyls si otn srlyeivebr eefftcad yb uni.lins eTh iqtonseu sask for eeslrirvbe wsya ttha nilunsi atfesfc i,t dna ttiiinibauuqno ouwdl alde ot tgedaadniro vai psete,aors whhci si otn eblsierver. pictla/ocNmuesylarc nhuitgns maske essne baseceu FOXO is a tannirpsocrit aftcr,o os ti t’can do its ojb if it is in het aops!cmytl

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meningitis aThkn oyu rof ouyr opetx!nlaani n eO iou:sqten owH auobt hte nisere osyt?oniaophprlh sI it srneeawd by urpe zoiamtneimor tath eht OFXO FT is isrene pyhsepdtlorh,ao or si it a ganleer actf atth lal s'FT ear inhretn-eesnoire lsphpdrooythae? +

tsl19 mI' nto eusr, but it amy eb as lsiemp as hst:i aitnq-duiuidiemetb tplyeosrosi si lbrse,revieri tub thbo NC/ stgnltuhi nda phytonrioaphols rae galyrlene ebrreivlse ssos.rcepe +

didelphus I sola sdgusee taht OXFO umts be a trap fo eth 3PKI py,thawa since niunlsi lrtgseuae aoibemsmtl ruhtgho KI3P adn the qtoseuin mset slilapeciycf oisntemn t.tah nphoyaiosProtlh is a jarom trap fo ttah ptwaay,h so eevn ednyictilr yhotlaosnhpropi dulwo tlaeerug OFOX. itFrrutgnsa qnouetis. +21

niboonsh yes, OXFO si ftadcfee etmsnoawrd of the nattocvaii of IP3K. shiT si a eylral dgoo oveid htta sniealpx eth owleh dcsceaa matgd/Los.:yuuctw?hN9o4cww.e-/v3tsbptew/h=w +2

alexb dcignrcAo to iipwideak (/XswhOirdOe/1k:wne/i.p.a/gkttiipFoi) ohltpihooryanps fo O1FXO is srlerib.eervi isTh si rirnfrege to loptrhoiosphnay fo neiser drueeiss on FOOX yb A,kt hchwi usrcco in pseoerns to isn.nuli Btu the BMNE ernasw ugestsgs 'ist irsvrlee.eb hats'W u?p +2

almondbreeze uodcl iiwk eb orwng on nloiphpaosrthyo eigbn l?veeserirrib ngcdrcaoi to tshi ai,crlet ti is a reilserebv ceprsos: eolguanitr fo xoOF irotitrsnnpca frosact yb sirevrbele hplisrooynpthoa nda tnytlaoeica (0l/74ew0/rh/ip0ccc7aSmste.ncsecn18irestei01/01o1wic0s:6.#i3e85wtpi0t/dc/9 e)som iwki ,oifn ,verhweo is ehfupll : nI its padetsuhory-ponhl s,aett XO1FO is ieloazlcd to the cnlues,u weehr ti idbns ot the nnsiiul rnesopse eusnqeec adctloe in hte omrteorp rof oscuegl aoas6-htephsp dna rsceniase tsi tare of nsirrcp.taonit FO1XO, ohhrtug iangierncs iacnirrnsptot of caps,-e-aposelthou6gsh recldyitni essecarin eth atre fo cetihap osuelgc [uito.rnp]do19c e,eorvHw nhwe 1OXFO is toysloehppdhra by tAk on 4T2r,h- ,-26rS5e and S1e3,9r- it is uecdxlde ofmr eth sucnul,e ehwer it is hent qendibauiuitt dna rad.edegd The iolrpthasoohpny fo 1OXOF by kAt beesuyuntqls aerdsecse hte ephtcia gelscuo cdotipnruo uorhght a reeeacsd ni nitopirnactsr fo souelcg ha6eap-ho.psst +

leaf_house It seems ielk teh onhhoptpayisolr rofm tAk eslad ot itcedstuorn, but bemay eht npasoimstu si hatt atth lsroopyoathhpin estp xclug(ndie veyre threo tpse fo u-iioqbtintrupeseoom h)ytaawp is vbe,elrrsei eerwh oisetpolsry si l.anfi b nhson@io idveo si odog but ds'tneo split hsti .one +

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submitted by ∗imgdoc(183)

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This uqetnosi si gainks atuob eht nusiiln ocrpeetr rsoeinyt neiask patyah.w So aetk it rmfo ,hrtee

ehT rolhnhipsptooay fo eht ISR eacvatits a lniags sdtiturannco aecsdca ttah aelds to het anitcoaivt fo otrhe naeksis as ewll as isnotrtacripn ftcsroa atth eimtade teh eularlrclitan tfcefes of sn.unili /ptmlrlcuysNCaecoai stulhntgi - yse i(vrsrel)ebe
rerThe/einninSeo kienssa rae osal nnkow ot udrcee teh vyiaictt of ns.ilniu - sey ()eeeirlrvsb
Utiubinqi - itmdedae possirleoyt - on nto( ir,veerel)sb dna sloa ninusil mytoclabliael anesircse ronitpe teysnishs os it t'odsne atmch hwta nsiiunl edso snyaay.w

crrecto em fi m'I .wrngo

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usmle11a i kihnt yuroe coretrc cuaes qunbuiiit taeimdde oeiyplorts is an lisvrbreeeri t.pse +1

+7 upvote downvote
submitted by ∗hello(429)

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Teh Q smet aestst OOFX is a atnstrpiinroc foartc ttah ndrepsos to iusnnil liggnnasi by iaerlgnt hte rtocnitrnpsai fo miatboecl sngee tg&--; eeohtfr,er OOFX si a insptcrntraio aofctr ivnevdol ni .ombamlstei This ushdol emka sense bcseeau -ilotcreesinnpru niattiovca ahs a role ni argtilgune mseaibt.mol

hTsi Q assk atuob lvesirerbe sway that inlinsu uegsreat FOOX tpsnrnoicrta rcafto tyt.ivcia

-daitbiqitedUmuine pytsiloeros si errsrbilieve. mEliatein lla esohicc tpexce rof B, D, nda H.

oIespricsne-rlnut inofuctn ghurhot 3KIP ainsg.nlig PK3I alnsgniig lvoveisn ontihylhrapposo of nersie &-;-gt senrei irtnopyhaslhpoo si a slbirervee crsespo. tlnmieEia H. FYI: iaoeo/nrimntp iacd yainprtoophsohl is alsway berlev.irse

uYo rae elft htwi chceios B nda .D

XOOF is a piniratosntrc atfocr -;>- roainrstpctin otfacsr temidae neeg iytctaiv by utitlghsn bwnteee eth palomcyts dan n.celsuu aRlituggne the itcaonol fo OXFO tniasirtcronp cartof (i.e. symltpaco .vs ncusl)eu lilw refeohtre lrreevbiys eotuldam Xaitemed-dOOF otbmaclei eegn yvt.itaci

ihsT avelse you ihtw eht cocretr wsnera: eCochi B.

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adong A tetber yaw to kithn otuab it si nsnuili satc trugohh MPAK chhwi si a ieeoenrtrhines/n snkiae +1

amy I tepetidaetnr NtoeCluapasc/mycrli linttushg loduw eb teh stuerl fo eisren opslriyp,thhonao os eth beerirvesl iocomifaintd si nlyo no esrine ylahoh,pospoitrn hwich dlea to lartaemcocyic/nsplu nhsiu,gltt tbu eth sunltigth ietsfl is ont nedur o dtic.Imfnioai gto it wnorg. +

+1 upvote downvote
submitted by ∗usmleuser007(464)

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eirneS iloparyonsthhop lilw deceru uisn'lnis t.cafefs tI scat on teh ieorsynt inkeas.

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alexandramda d-e:reh/07.wn0f8t0lw0coo.-0t99cm(cop.i/-/t/lp83dsypl9bu220g)rw/f6S +

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