NBME 21 Nuclear/cytoplasmic shuttling: yes;<br />Serine phosphorylation: yes<br />Ubiquitin-mediated proteolysis: no (NBME Answers)

Retired NBME 21 Answers

nbme21/Block 4/Question#4 (reveal difficulty score)
The FOXO transcription factor responds to ...
Nuclear/cytoplasmic shuttling: yes;
Serine phosphorylation: yes
Ubiquitin-mediated proteolysis: no 🔍 / 📺 / 🌳 / 📖
tags: biochem

+13 upvote downvote
submitted by calcium196(12)

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idtdeb-Uqiituinmae poiryotsles is otn evbislerry eafftedc by slii.unn Teh oqetiuns kssa for ielerevsbr wasy ahtt ulniins fsfatec ,ti nda itnoaubiiiqtnu lwodu elda ot naitdoergda avi ao,erpesst whhic is otn bvrreleie.s sylcmNircucaoael/tp snhintug askme esnse seabuec FOOX is a aitosnrcinrpt a,cfotr os it ta’nc do ist jbo if it is in the splatyo!cm

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meningitis nhkTa oyu rof ryou taaexnpi!oln n e O qoniuest: owH otaub the irenes yohapthp?onslroi Is it wedrenas yb prue ioaeirmmotzn thta hte OOFX FT si eirsne t,dohplapsyrhoe or si it a naergel tacf ttah all 'FTs era hteier-reonennsi apsphehytrol?od +

tsl19 'mI ton rse,u btu ti yma eb sa plsiem as sh:ti iuii-ubqemndtaited oeosisplrty si eeibisrrrelv, but htob N/C shtiulntg and ahsythprlonpooi aer gelnrleay eeribvslre croese.ssp +

didelphus I asol edguses htta OXFO umst be a atpr of eht 3IPK wat,hapy sncei sniuiln euglraest bimmsletao hutgroh IP3K nda hte einsquto tsme lfcclspiyaei stenmion hatt. hpiolhrnotaosPy is a rjamo ratp of htat ayw,taph so eenv iriydlentc oohnrshpoiyltpa udlwo gtareuel OO.XF Frsranttuig eoi.nsutq +21

niboonsh e,ys OXFO is cetfdaef rdmeowntas of eht atctiviano fo .KPI3 Tsih is a aelylr good diove tath pasxline hte eolwh caadces w94wg.ve?wab-Lp/mttec:u=h/c3Nst/udwoowh.tsy +2

alexb ciAdrgnoc to iikwaeipd (nh.igiO1p.ierkat/iw/XtkpO/od/:iwFes) aopohloinytphrs of 1XFOO is ilebsrver.ier Thsi is frreeginr to ohoporistnalhyp of rienes desrsuie no XFOO yb tkA, wchih cocusr in eseronps to nilinsu. utB the EMNB wrnaes gegustss sit' eslrebivr.e sht'Wa up? +2

almondbreeze duolc kiiw be orgnw on ylarpnopsoothhi bgeni ?rribsivleere inacorgcd ot tihs retca,li it is a sevrerlebi rps:ecos lanoertgiu fo xFOo rsartcniptnio srfacto by beiervrsle nitpharoslhoopy dna eicttaylona (90tiocr0e0/e3/ci1i..8lt1swst6cwt0pa08e:51i/1e/#c7mpniw/0snr4dchSeic7/cs0eseo m) iikw oinf, roeehv,w si lufphle : nI tsi nloopydhaesrtu-ph aett,s 1OOFX si ioladeczl to the e,cuulns rehwe ti dbsin ot the lniuisn eosrsepn qeueencs deltcao ni hte ormproet rof esuoglc -pps6hstaahoe nda ercsnesia its trea fo rrinos.paticnt OO1,FX hgothur esnnciargi tcornpsnaiirt fo g,spalhe6eoou-t-csspha licrideytn eianrcess the reat fo tiachep cuogels ur9c[.d1poitn]o ewrHo,ev nwhe OX1OF is aooyhtpsdlhepr by tAk on T-r4h2, -e625rS, dan S9,-1re3 ti si ddcxuele rmfo teh u,eslncu wheer ti is ehtn qtbtaidieuinu dna ddg.daree Teh yoohpsnrhplaoit of OO1FX yb tAk seqyltbuunse esdarcees the heptaci elgusoc oncoturpdi rtohhgu a ceerades in nrntpratiosic of uscgole -hopstaapsh.6e +

leaf_house tI meses ekli teh psyhhoinaporlot from Akt aslde to etcouts,dnir tub yemba het umontssapi is ttha ttah stloiahppyonhro tsep n(ugdxiecl reyve ehort ptes fo ouiuersoembqi-npotti )pahytaw si evs,rlbeier ehwre srpoiyolset si an.fli shbn@n ioo dovei is gdoo btu dotse'n pslit sith no.e +

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submitted by ∗imgdoc(183)

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sTih esiutnqo is gniska oabtu the inisuln rorepcte rseniyot ianeks atwhap.y So teka it ofmr ehtre,

The oshtipolyhproan of het SIR tsacatvie a lasnig ncortsdiuant ceasadc hatt asedl ot the inaaotvict fo other akiness sa wlle sa anitosnrpctir rfcoats ahtt aedemit the lrtueliarclan fsfteec fo niinl.su CsumllrNoytp/caicea hugtnltis - yse eilber(vse)r
niereeenirn/oThS askinse ear sloa nknow to ucdere het vcittiya fo siiunl.n - yes b)i(vlreeesr
uibiUtnqi - dteeiadm itrlyooepss - no (otn erieesblvr), dan asol unilisn tioamcbellyal reeiscnsa ripteon nhsitssye os ti esodt'n chtma hatw linnsui esod ynaawsy.

rctocre em fi mI' r.ognw

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usmle11a i hitnk euryo erotccr uasec ubiqinuti mteidade lioyotpsre si na rsevreerbiil tsp.e +1

+7 upvote downvote
submitted by ∗hello(429)

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ehT Q mest astest FXOO si a staintrrcpoin rfaoct ttha sspoednr to ulnisin inaggilns yb lagrniet eth ncrprtnisotia fo teicabolm seeng --&tg; trroeh,eef FOOX is a riontrasptcin rfocat vldivoen ni lesmtimoab. hTsi duhosl eakm senes ebsaecu neociespintu-rrl aoiiantvtc sha a oelr ni ntlugeirag lmbmtias.oe

hiTs Q kass atobu eierrbelsv wsay atth uininsl eurtgsae FXOO niraronstcpt fcoatr iycaitvt.

da-itnteibeqiudUmi pseoslortyi si eielriesrvrb. eaiiEnmtl lal chcsoie pteecx ofr ,B D, dna H.

iprnscr-seenItuol nnuctiof hghrotu 3KIP ggnsin.ail P3IK liasggnni ovveslni tsproapyiohohnl of inseer ;--tg& ineres lhaonirtooppysh is a lvsrbrieee cero.sps niEemlita H. IFY: otpernma/iion dcai osrlohyopipahnt is alsyaw esvlirb.ree

oYu ear ltef whti hseocic B adn D.

FXOO si a roicpnrtiatns rtaofc --&;gt ipnstrntrocia carotsf imeated nege iavytcit yb lnhigsutt benwete hte apcyltmos dan uusn.elc uetnlRgaig het itoanclo of OFXO otnrpitaricns artcfo .ie(. lamycsopt .sv nceu)uls lliw rreeoetfh yrreslevbi uatmldeo Fmd-deXtOOaei otcaliebm egen tytcii.av

siTh eselva you thwi eth oectrcr waen:rs eicohC .B

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adong A btreet ayw ot knhit atoub ti is lnnsiui ctas hghtour PKAM chhwi is a iesoreitnee/nhrn kiasne +1

amy I eniettetdpra iacNlaoeupymCr/tlsc tsnhtugil doluw be the elstru fo neersi topsiloyroha,hpn so the vbieeserlr mdiainoifoct si olny on irnees prhoyio,tnaphlos wchih edla ot eonturclsycapm/aicl ,lgihtsutn tub teh tsiugnhlt sftlie is not durne omif.dcni itaoI ogt it g.wrno +

+1 upvote downvote
submitted by ∗usmleuser007(464)

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Seenir soahoynphtoiprl lwli ueecdr s'nsinliu sffct.ea tI tacs on the etirnosy .kniaes

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alexandramda s9oi.bmg//8.t/3w8nwflf0c-cu0t07.oe/pc-)rlr9/Sp(o6lp0:y-9hd0w2d02et +

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