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NBME 22 Answers

nbme22/Block 2/Question#18 (20.6 difficulty score)
A 32-year-old man comes to the physician ...
Reverse transcriptase🔍
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as @mtfp said, NRTI need to be phosphorylated by HOST CELL thymidine kinase, mutation in viral kinase has no role in NRTI resistance.

Need to put as separate comment as wrong explanation is at top.




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shTi qinsteou is os iynnnaog tub isht panxatleion si osedpurpt yb reavels eppsa.r




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submitted by lamhtu(86),
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It peapasr tath lahthogu NsITR are hradolphpsotye yb tnemiiyhd se,ikna esistarnce si aylacltu ude ot utnatmsoi ni hte acualt esreevr tasterncpsair reahtr tnha etiydnimh akisen .tslefi

forerofore  mutations in thymine kinase are more frequent in herpes drugs +3  
mtfp  NRTI need to be phosphorylated by HOST CELL thymidine kinase, mutation in viral kinase has no role in NRTI resistance +10  

as @mtfp said, NRTI need to be phosphorylated by HOST CELL thymidine kinase, mutation in viral kinase has no role in NRTI resistance.

Need to put as separate comment as wrong explanation is at top.

+/- b1ackcoffee(23),


What does Zidovudine act on? It is a rev transcriptase inhibitor. Resistance often occurs at site of drug activity.