NBME 22 Reverse transcriptase (NBME Answers)

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Retired NBME 22 Answers

nbme22/Block 2/Question#18 (reveal difficulty score)
A 32-year-old man comes to the physician ...
Reverse transcriptase 🔍 / 📺 / 🌳 / 📖
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+5 upvote downvote
submitted by ∗b1ackcoffee(115)

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as @mtfp said, NRTI need to be phosphorylated by HOST CELL thymidine kinase, mutation in viral kinase has no role in NRTI resistance.

Need to put as separate comment as wrong explanation is at top.

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+3 upvote downvote
submitted by ∗adisdiadochokinetic(89)

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This question is so annoying but this explanation is supported by several papers.

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+1 upvote downvote
submitted by ∗lamhtu(139)

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It appears that although NRTIs are phosphorylated by thymidine kinase, resistance is actually due to mutations in the actual reverse transcriptase rather than thymidine kinase itself.

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forerofore mutations in thymine kinase are more frequent in herpes drugs +4

mtfp NRTI need to be phosphorylated by HOST CELL thymidine kinase, mutation in viral kinase has no role in NRTI resistance +14

as @mtfp said, NRTI need to be phosphorylated by HOST CELL thymidine kinase, mutation in viral kinase has no role in NRTI resistance.

Need to put as separate comment as wrong explanation is at top.

+2/- b1ackcoffee(115)

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+0 upvote downvote
submitted by ∗jessikasanz(9)

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What does Zidovudine act on? It is a rev transcriptase inhibitor. Resistance often occurs at site of drug activity.

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