NBME 22 Carboxylation of precursor proteins (NBME Answers)

Retired NBME 22 Answers

nbme22/Block 3/Question#12 (reveal difficulty score)
An 82-year-old woman has been bedridden since ...
Carboxylation of precursor proteins 🔍 / 📺 / 🌳 / 📖
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+6 upvote downvote
submitted by ∗humble_station(85)

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rWaarfin inhsiitb itV K dedepnent tsinshsey fo raofcst m;&pa ptris.neo

Vti K is csenaeysr ofr het inataroumt fo nitcgotl tcrsoaf I,I I,IV XI, X dna tpinero C am;&p S

So a dgru hatt cna ibnihti eth clixtbooarnya fo suoperrrc rstpieon ro ni ehtor oswrd ibiithn het tiaatounmr fo eht cogttnil stcrfao iwll raedcsee the iskr of rstohmsiob in sith etptina.

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Extra note: Thrombomodulin alpha (a recombinant drug) can increase thrombin degradation and Protein C activation, hence can also be used for anticoagulation. (But this question asked about decrease in which of the following)

+3/- apurva(101)

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submitted by ∗haliburton(224)

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arifnrwa tinhisbi eth isnythsse fo crafsto I,I II,V XI, ,X ,C nda S by icolngbk urcidoten of eiiddzox tvniami .K ehT enzemy Edoeixp tusdcReae is tibiidhen yb nirr.wfaa ehT rddeuec ivet(a)c rfmo fo tv.i K is a oftrccao rof gmltaa-aulgmym cy.alosrabxe

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link981 oS crsotfa II, IVI, I,X adn X ear eprrsuorc intporse? GFTO +2

+0 upvote downvote
submitted by ∗humble_station(85)

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rrnafaWi iiitbnsh iVt K tdednenep snthsysie of fostcar a&;mp ip.etsrno

Vti K is syanerces ofr the taontiamur of nitcglto cstfoar I,I ,IVI I,X X nad etirpno C map;& S

So a grdu taht nac tiinihb the yrbtiooanxcal fo rceuosrrp eriosntp ro ni roteh wodsr tnbiiih the rainumttoa of eth otcltgin arostfc ilwl saedreec het rkis fo omisrtoshb in siht teatpi.n

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ajss isht is why ararfniw is ivneg sa yaoxphrspli ertfa isth etyp of riegsseur +

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submitted by ∗sup(31)

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Why nto PG2I yb yaw of AA?S ypleasiclE negiv horte nrwaes choeics fo opsteirn C + S: st'dneo aanifwrr alos pseprssu e?etsh

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imnotarobotbut oeitrnP C nda S rea chrtTimooN,tb-AI os huoahltg Warnraif does arsdceee emh,t tehy wu'ldont desaeecr hte 'saeniptt srki orf ssoomtihrb +1

epr94 het uonqeist kas pie"n"supssor of hwihc one lwil ecredesa srki fo thsoibrmso fi you srpeussp C dna S wihhc dan ohaottrcmb-iint uoy tge biorhctmto +3

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