NBME 22 Answers : Block 3 : #49 = A 42-year-old man is brought to the emergency ...

nbme22/Block 3/Question#49

A 42-year-old man is brought to the emergency ...

Dopaminergic neurons in the substantia nigra

+0 upvote downvote
submitted by yotsubato(207),

"MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) is a prodrug to the neurotoxin MPP+, which causes permanent symptoms of Parkinson's disease by destroying dopaminergic neurons in the substantia nigra of the brain. It has been used to study disease models in various animal studies." Wiki

ilikecheese pg 508 FA 2019 +1

sbryant6 I thought this was testing "lead pipe rigidity" aka Neuroleptic Malignant Syndrome and its connection to dopamine. Had no clue what MPTP was and got it right still. Probably wrong train of thought though. +

-1 upvote downvote
submitted by sunny(0),

FA pg 508 (19) mptp causes parkins..................................................