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NBME 24 Answers

nbme24/Block 2/Question#9 (reveal difficulty score)
In which of the following stages of the cell ...
G2 πŸ” / πŸ“Ί / 🌳
tags: cell_bio 

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submitted by βˆ—sympathetikey(1535),
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+DC4 lcesl vaeiattc cselBl- hhcwi mfro ellflsioc nda esuac megntenearl of myhpl eosn.d Tre,reefoh in na SIDA ,eipntat ot aelngre hte hymlp ,ndsoe the DC+4 ysnunoifdtc tusm eb sevordl.e

submitted by βˆ—snoodle(32),
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jtus aedtnw to add atht itossquen hatt aks laslm setiald klie tihs akme me awnt to cearv my laelesby uot

j44n  This is the shit that keeps me up at night +6  
jbrito718  I just realized its asking about MITOTIC cyclins +  

submitted by βˆ—madojo(192),
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therAon way to knith oaubt itsh is whtas teh lsesoc gesta ot sotsmii uecsbae ghrti eeofbr M sis(o)mti oyu eden ot vhae titciom icslncy znsised,eyht nad that wodul eb G2

1G -t&g;- S ;-t&-g G2 ;g&-t- M

submitted by βˆ—sweetmed(154),
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incyCl ED,,A adn orf 1G to S ninitorsat mead[ in G1]. nClcyi B si for G2 ot M mnsti[itaoerdan ni G]2.

submitted by βˆ—nerdstewiegriffin(42),
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1G oikchpcten: ciyCln D/4DCK cmplexo wiht 53p adn rb G2 :khopicctne niClcy B adn DCK 1

ayW to erm:rebme 1G is adceasitso tiwh grhhei ersnumb D adn 4 G2 is atesoicsad iwth B dan 1


nda osal @FKC me adn C@FK M!!EB!N

snripper  But the question doesn't mention anything about which cyclin. How does this help? +3  
thyenman  @snripper I think the word choice of "mitotic cyclins" is suppose to show they wanted cyclin B which is produced in G2. This resource specifically refers to cyclin B with mitosis. CDKs and different cyclins are expressed at different stages of the cell cycle: cyclin D (G1), cyclin E (G1/S), cyclin A (S), cyclin B (mitosis). - +4  

mousie +4  
fahmed14  Cyclins help regulate cell cycle phases. They help with checkpoints before progression to the next phase of a cell cycle. Therefore the checkpoint before mitosis would be in G2 and probably where mitotic specific cyclins are synthesized +12  
artist90 . 4 types of Cyclins and when they rise and fall. +2  

submitted by βˆ—angelbarrera(1),

Main groups There are two main groups of cyclins:

β€’ G1/S cyclins – essential for the control of the cell cycle at the G1/S transition;
β€’ Cyclin A / CDK2 – active in S phase.
β€’ Cyclin D / CDK4, Cyclin D / CDK6, and Cyclin E / CDK2 – regulates transition from G1 to S phase.
β€’ G2/M cyclins – essential for the control of the cell cycle at the G2/M transition (mitosis). G2/M cyclins accumulate steadily during G2 and are abruptly destroyed as cells exit from mitosis (at the end of the M-phase).
β€’ Cyclin B / CDK1 – regulates progression from G2 to M phase.

cellgamesgojan  hi there. please try to format your comments. this will improve readability and helpfulness. thanks! +  

submitted by βˆ—blue4415(3),
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obmAss for icn:cly

G2 octiche:npk A lecl dsvionii pctnkocieh idngru the 2G
cCks he rof NDA gaamed and eetsplsmoenc of NAD tiplaicrone
eIsntaiit somisti by arhsnippooyhlto of avrusio nrsptioe .,.ge( thei)sson
glutReeda by eth tismsio poogtmrin orcaft (FMP), hhwic is sdpoecom fo C1kd dna ycclin B.

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