nbme24/Block 2/Question#21
A 50-year-old woman with HIV infection comes to the ...
Zidovudine
adisdiadochokinetic
Azithromycin is a macrolide, not an aminoglycoside FYI, and its use in HIV is primarily as prophylaxis at very low CD4 counts for, among other things, the mycobacterium avium complex.
+2 2019-07-20T20:24:59Z
nbmehelp
How would we have known to choose Zidovudine over Lamivudine tho
+1 2019-07-24T21:29:28Z
mjmejora
@nbmehelp the sketchy with Princess Izolde (Zidovudine) eating bone marrow was my only tip off
+1 2019-07-28T16:28:14Z
submitted by neonem(227), 2019-06-01T21:03:02Z
NRTIs are the main HIV therapy drug that can cause bone marrow suppression (not as common with NNRTIs). This class includes zidovudine, didanosine, emtricitabine, lamivudine, stavudine, abacavir. Zidovudine is most known for this side effect.
Nelfinavir = protease inhibitor azithromycin = aminoglycoside (not really used for HIV) pentamidine = another antimicrobial, mostly used for pneumocystis I think? Lamivudine = another NRTI but less known for bone marrow suppression