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NBME 24 Answers

nbme24/Block 2/Question#50 (31.4 difficulty score)
An obese 57-year-old man comes to the ...
Normal ciliated columnar epithelium replaced by normal squamous epithelium🔍

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submitted by lsmarshall(396),
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shayan  if its a metaplasia, then how it be normal ? I mean Metaplasia is not normal? +2  
artist90  i got it confused bc the question stated that there was a mass in one lobe of lung and i didn't knew that squamous metaplasia also presents as a mass in lung. i missed that on biopsy they were clearly stating squamous metaplasia. +4  
suckitnbme  @shayan The term "normal" in the answer is used to indicate that the cells appear normal (meaning appropriate size/architecture/appearance). Remember that metaplasia is a normal response to stress. +8  
jurrutia  Metaplasia is not normal (in the sense that you only have metaplasia as a reaction to stress, but under not under normal circumstances), but the cells in metaplasia are normal. When they become abnormal, you get dysplasia. +  

submitted by medguru2295(35),

they said "metaplasia"

Metaplasia= normal tissue but in an abnormal place classic example- Barrett's its NORMAL mucousa for the stomach, but in the esophagus.

submitted by thisshouldbefree(26),

metaplasia - (as i learned its definition to be) - defined as replacement of one mature/normal epithelium with another mature/epithelium that is better well suited to handle stress.

thisshouldbefree  also dont forget metaplasia and even dysplasia are still reversible +  

submitted by krewfoo99(90),
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ishT uolcd iaelsy be eocfsdnu ihtw samuqSuo Clle mnairCaoc sa tyeh ear nrciebsdgi a sam.s But i tnhik eth key eidncfrefe si ttha hyet onetmni AAAIPESLT.M If it was siaya,dspl ehnt ti uoldw evha enbe cnc.rae

usmlecrasherss  metaplasia also can lead to cancer FA p206 2019 +  
suckitnbme  Dysplasia is not cancer since it is, in theory, still reversible. Only when it becomes irreversible is it a carcinoma. +1