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NBME 24 Answers

nbme24/Block 3/Question#8

A 37-year-old man who is a farmworker comes to the ...

Synaptobrevin

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submitted by lsmarshall(192),

Synaptobrevin is the target of tetanospasmin (tetanus toxin); muscle spasms are characteristic. Only other answer you might consider is Acetylcholinesterase since he is a farmer and buzzwords often carry us to the promised land... but symptoms of a cholinergic storm are absent.

vshummy  Synaptobrevin is a SNARE protein. Why they couldn’t just give us SNARE I’ll never know. +13  
yotsubato  Cause they're dicks, and they watched sketchy to make sure our buzzwords were removed from the exam +9  
yotsubato  Oh and they read FA and did UW to make sure its not in there either +7  
soph  This toxin binds to the presynaptic membrane of the neuromuscular junction and is internalized and transported retroaxonally to the spinal cord. Enzymatically, tetanus toxin is a zinc metalloprotease that cleaves the protein synaptobrevin, an integral neurovesicle protein involved in membrane fusion. Without membrane fusion, the release of inhibitory neurotransmitters glycine and GABA is blocked. -rx questions! +1