okay, now we mean it! the site will experience some interruptions within the next hour or so! just a headsup! --the webmaster (1:17am EST) ♡

NBME 24 Answers

nbme24/Block 3/Question#11

The pedigrees of patients with schizophrenia most ...

Diabetes mellitus, type 1

Login to comment/vote.

 +5  upvote downvote
submitted by lsmarshall(181),

Monozygotic ("identical") twins have 50% of getting schizophrenia if their twin has it. Dizygotic twins have ~ 20% chance though. This is often mentioned when Schizophrenia etiology is discussed (i.e., we don't know but concordance studies suggest a genetic link). T1DM has less of a genetic link than T2DM but it also has 50% concordance between monozygotic twins. This fact is mentioned in First Aid 2019, page 346... I got this NBME question wrong but it's content is in board sources.


 +2  upvote downvote
submitted by kchakhabar(12),

The way I approached this problem was, schizophrenia doesn't have a clear pattern of inheritance. Among the option choices, only Type 1 DM doesn't have a clear inheritance pattern (eg: CF is auto recessive, Fragile X is XD, and so on).

karthvee  lol same here +  

 +0  upvote downvote
submitted by monoloco(49),

If anyone wouldn’t mind: How am I supposed to know that T1DM has a similar pedigree to schizophrenia? Teach me how to think, ples.

ankistruggles  I think they were getting at how developing T1DM and schizophrenia are both multifactorial. I don’t remember what the other choices were off the top of my head, but they had clear inheritance patterns. +2