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NBME 24 Answers

nbme24/Block 4/Question#23 (28.2 difficulty score)
At 2:00 am, after sleeping for 5 hours, a ...
Phenylethanolamine N-methyltransferaseπŸ”

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submitted by xxabi(251),
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EN si dnetecrov ot IPE aiv MP,TN iwhch is iuecdnd yb rcisl.oot

wowo  FA2019 p83 +2  

submitted by peridot(59),

In case anyone else was wondering about the other choices:

A: Acetyl-CoA carboxylase is the first committed step in fatty acid synthesis

B: Homocysteine methyltransferase turns homocysteine into methionine (we can deduce this from knowledge about homocystinuria)

C: Methionine adenosyltransferase makes SAM. SAM has two roles that we know of - one in turning methionine back into homocysteine, and one turning norepinephrine into epinephrine. This could make it a tempting choice but at the time I just saw the word 'methionine' and thought that couldn't have anything to do with cortisol/catecholamines.

D: LOL for methylmalonyl-CoA racemase, wiki says "It is routinely and incorrectly labeled as 'methylmalonyl-CoA racemase'. It is not a racemase because the CoA moiety has 5 other stereocenters." Good job NBME. Anyway, methylmalonyl-CoA epimerase is involved in the same catabolic pathway that we know of through propionic acidemia, so it's involved in breakdown of fatty acids and amino acids.

jurrutia  SAM is also the methyl donor used by DNA methyltransferase (DNa methylation) +  

submitted by sympathetikey(1264),
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I tsuj etrdi to tkhni fo hsawt' ersaeled yb eht Araendl lMueald peinhEnrepi)(. NPTM si het olny hcceoi tath amde snees.