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Retired NBME 23 Answers

nbme23/Block 1/Question#45 (reveal difficulty score)
A 56-year-old woman comes to the physician ...
Presynaptic release of acetylcholine ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
tags: msk repeat

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submitted by โˆ—step420(32)
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oesnrP has nLmt-aerbaoEt dsernoym h(x fo guln e,ccarn and emsluc catiivty thta is terteb iwht u.se

aritspnPecy Ca+2 dinobisate tevprne teh eeralse fo HAc payncsrpyilaetl bcsuaee eth eiidostnab etervnp eht rpitoandlzaieo wtihni hte ellc adn stevpern cnayitps vssseel fo hCA ofmr egilnav.

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thotcandy  gu,h I wsa aC2+ nad esodtpp niktnghi. +18
paperbackwriter  t@oncdatyh maSe erhe :( +2
sidlersofcattan  hety tog em oto thwi atth Ca++ irp +4
psay1  0A912F p.g 436 +1
meja2  oneLss lanet:r rade eth nswear heiscoc veyr urafeclyl (: otitmlyAaaucl ewtn ofr 2C+a +
chaosawaits  I sgues uoy cdluo lacl hatt a Ca.rttpa lI'l ees slmyfe ot.u +1

Patients with Lambert-Eaton myasthenic syndrome (LEMS) possess antibodies to voltage-gated calcium channels on presynaptic lower motor neurons, which decreases calcium influx and acetylcholine release to postsynaptic skeletal muscle cells.

In some patients, malignancies (eg, small cell lung cancer) trigger production of these antibodies, resulting in paraneoplastic LEMS Patients present with progressive proximal muscle weakness that improves with repetitive motion and exercise.


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submitted by โˆ—namesthegame22(14)
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heT tisynaopsctp emrnebma tneptailo ci(heoC D) yam eb daseeredc ni MESL sncydaoer to hte crsededea aceppnritys aserlee of nca.yltlecoihe = WRNGO .ASN

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