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Retired NBME 21 Answers

nbme21/Block 1/Question#12 (reveal difficulty score)
A 25-year-old nulligravid woman comes to the ...
Endometrial hyperplasia ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—mcl(671)
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OSCP si tadcosieas iwht nrbalmoa dcnootuipr fo esx o,risdets inudlcign ntosicnfyud of sgoetenr ocodturnip dan eprno.grsoeet nrchaiolCyl tdvelaee ellsve fo esrnoget nac uesac monladieret aleasrhi.ppy

n/.n../9m1ccPc9/olrw:etivwt7pmini9C//M/halwghs.tsp35b

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meningitis  hWy stin ti oer?nioiemstds oCdlu ensoeom help me tuo on ?tsih +2
meningitis  S,ryro I saw nofncisug htiw eigrhh sikr orf mroenitaedl aaro.cicnm +1
vi_capsule  gneotsEr si bieplsrenso ofr lylcicca eidnlegb nad naip sceaiosadt tihw ieemrodniosst hecne pgsirntoe si a tettranem tilyaodm. tuB gneeotsr stni a krsi coftra rfo osdo.mEitrsein Rhtrae etehsr degrtraore ,lwof ecimlttaap rotimnaosnatrf cet ioseerth aer ebspresioln ofr oimretosndise. +1
sympathetikey  fwT uoy get so whront fof by a iucretp hatt yuo tond' dera eth seqnuiot rye.prpol +34
hyperfukus  snein@gitmi dik if u sltli cera llo ubt awlsya go bakc to ocmdp=esioroiscetiten eenlmrtodai tiessu sotueid of the usuter os uyo nac leur it uto nesic aeniecdsr tnresego duwlo euacs ouy ot veha rswoened rdssmineooite ro a ctikher eno tub otn cul.od.yityer. nca ese eth psucml fo hte ilocelfls ni eht voirase if oyu oolk urpse lsoec so atht galon wtih hte ropatesitnen kstae you to SOPC dna iemnyat yuo ndt'o hvae a ybab ro tasy ni het olerpiveirfat reeahnsgtseop( pseh)a oyu gte niteoelamrd eeitrmaoa-tit&ge-iiyrol-gslr-ly-ahlfpaput;tn&p; orcicnama +2
lovebug  AF 1,209 agep 163 +1
lovebug  ethOr reswan )iHgsMe myednrso : trida fo 1) iarnaov brofam,i )2 ,sseitac 3) aplurle oisnufef. lligโ€œnโ€Pu saisentno ni .inrog FA 09,12 gp 326 +1
xw1984  nIts' tonoip G, aommeatyioL ,tieur etdcoasisa with hhig greoents elvl?e rPe FA 20,02 bfrdoii is etrngseo estv.einsi +2
ownersucks  w89@1x4 sgsro ameig ouwdl oswh plmeitlu wroelhd sesmas +1

I feel the clearest way to understand this question/answer hasn't been stated yet. Recall that the cysts in PCOS are unruptured follicles. If follicles don't rupture, you won't have corpus lutea, which won't secrete progesterone and therefore menstruation won't occur. This leads to unopposed estrogen and disruption of the menstrual cycle, which can cause endometrial hyperplasia.

+20/- pg32(218)

The patient here is obese and has hirsutism. Her androgens are converted to estrogens in peripheral fat, causing hyperestrogenism.

The exact reason for increased androgens in PCOS is unclear, but it involves an increased LH:FSH ratio. Relative decrease in FSH inhibits estradiol synthesis in granulose cells and favors androgen production in theca cells.


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submitted by โˆ—pparalpha(93)
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oCmiaspolcnit fo O:SPC

udasorcCaravli etvens

Type 2 asdebtei meitlusl

Einldomerta cancerayphrs=pelai

aInesrdce ercmasaigir tare

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