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Retired NBME 21 Answers

nbme21/Block 1/Question#12 (reveal difficulty score)
A 25-year-old nulligravid woman comes to the ...
Endometrial hyperplasia ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—mcl(671)
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POSC is cosaatised wthi mnraboal rtdnoupioc of xse eitrs,sod niiudcgln nufciyndsot fo gotnseer dtcoropniu adn .nrgeroetsope nlrChyciaol ldteveae eelsvl of onrseegt acn suace ndarlmeoiet saelpy.aphir

m:h1.viiwsC/b3c/l/l79p.rhpwtn9i.n/c5.wtctgonPms/9/Mae

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meningitis  Why inst ti oesnesdiroitm? Cloud eosnome hple em otu on ?siht +2
meningitis  o,yrrS I asw ousfgincn iwht reihhg irks for dmlnreetaoi cm.ioanacr +1
vi_capsule  tsEgnreo is ssebpielrno for licccyla eigdbeln and inap asidsteoac hitw oiroesmdneits hceen pogsenitr is a raetenttm otdm.lyai tuB gerosetn nsit a krsi rcatfo orf .rosnomestidEi rRetah ehetsr doerergtar f,lwo ttemlapaci otrstafiarnmon ect rsietheo aer ebpesolrsin fro m.isienrdooset +1
sympathetikey  fTw ouy gte so howtrn fof by a repucit thta oyu 'tond ader hte soenqitu yrrl.oppe +34
hyperfukus  i@igetninsm dki fi u stlil ecra lol ubt ywlasa og cakb ot isitiocpooseem=tedrnc eromineldta iuesst suoietd of teh uretus so uyo anc urle ti tou esicn ciesrneda tgneorse udolw uacse you to heav srdoneew oeedionrsmits or a ciehtkr neo ubt ont tyurldi.coy..e cna see hte slumpc fo hte lieocllfs in eth iovrsae if uyo olok usrep lesoc so thta longa whti eth eeniarstotnp tsake uyo ot OSCP nda eytiamn ouy t'ndo aevh a byba or sayt in the ietravlfripoe hraesontg(eesp she)ap ouy teg ermlaioentd rleatr-toylfaurpig&pal;lehity&m;iaspeto---int-g miacrnoac +2
lovebug  AF 0,129 pega 613 +1
lovebug  hetOr wnares Meg)siH onymrdes : iradt fo 1) voarina obfm,rai 2) ,stiscea )3 lrpaule feuf.onsi niโ€œulPlgโ€ esnoinats ni io.grn AF 1920, gp 236 +1
xw1984  'nIts oitnop G, tyammioeaLo trei,u catseosida twih gihh gteenros ?llvee erP FA 022,0 rfidibo is esoertng seinstev.i +2
ownersucks  8914w@x sgsor emiga oluwd wosh eumltpil orwdleh assems +1

I feel the clearest way to understand this question/answer hasn't been stated yet. Recall that the cysts in PCOS are unruptured follicles. If follicles don't rupture, you won't have corpus lutea, which won't secrete progesterone and therefore menstruation won't occur. This leads to unopposed estrogen and disruption of the menstrual cycle, which can cause endometrial hyperplasia.

+20/- pg32(218)

The patient here is obese and has hirsutism. Her androgens are converted to estrogens in peripheral fat, causing hyperestrogenism.

The exact reason for increased androgens in PCOS is unclear, but it involves an increased LH:FSH ratio. Relative decrease in FSH inhibits estradiol synthesis in granulose cells and favors androgen production in theca cells.


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submitted by โˆ—pparalpha(93)
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acsiminopoClt fo O:PSC

adaCicsuroavlr tsneev

Tyep 2 asidteeb tslleimu

loedratEnim nracecraeisplhp=ay

redescnIa agisamericr aert

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