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Retired NBME 21 Answers

nbme21/Block 1/Question#12 (reveal difficulty score)
A 25-year-old nulligravid woman comes to the ...
Endometrial hyperplasia ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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submitted by โˆ—mcl(671)
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COSP si saiaecdsot whti abrnolma cuioordptn of xse ,drsioste dnigniluc fncsdiynuot fo etesgonr otoiuncdpr dan osrtepnee.org lhncloyairC vteedeal selevl fo oneersgt can acues ieoednlmtar pysra.plhiea

mw.pCnbmcs/tlnr/./ciPp9c9.3a:9hoMigs5tl//w7niht1.vwe/

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meningitis  yhW stni it eosrondtise?im uCdlo snmoeeo lehp me tuo on hsit? +2
meningitis  Srr,oy I aws uogfcnisn ithw heghir skri rof ioleenrmtda icaancr.mo +1
vi_capsule  gEsnrteo is lseersnipbo rof lyaciccl niebdleg adn ainp eoatiscasd whit oisenrmodesti eench nprtegios is a arttmteen imdaoyt.l Btu tgresone sint a kisr atfcor ofr i.rdnEesotsoim treaRh srhtee arrgerdtoe fo,lw taailpcmet ationtorrsfamn ect hoisetre aer eenlssiborp rfo emenoossrtiid. +1
sympathetikey  wTf yuo tge os trohwn fof by a cteipru atth oyu dnot' rdea eth siuentqo eppr.lyor +34
hyperfukus  n@iseitgimn idk if u sllit aecr oll ubt lwyaas go kbac to rp=tnecseemoiiitcdoso otirenmelda utsies iedotsu fo the utusre os yuo acn relu it uot ncise icdersean osrgenet owuld ecasu yuo ot avhe eodsnewr dsieeimonosrt or a ithekrc oen btu nto y...dteiyuclro can ees eht upclms fo teh oifelllcs ni eth srivoae if ouy kool rupes ecslo os thta ongla twhi eth rnnostetaeip tseak uoy ot OPCS dna temnayi uoy dot'n veha a ybab ro tyas ni hte iaflieteopvrr hnsrepeesog(ta )pehas uoy tge ornteilmaed apfg-eor;i-olan;r&lseiep-altypgr-ith<t-iuatym icrcamnao +2
lovebug  AF 9021, aegp 613 +1
lovebug  Oethr swnear )sgiHeM rnsoyedm : dait r of 1) vanirao ibomrfa, )2 csa,iets )3 ulaerlp oinf.efsu โ€โ€œgPullin otniseans ni goni.r AF ,2109 gp 632 +1
xw1984  ntIs' tpnooi ,G toaLmoemayi utier, stdiaoecas hitw hghi esnogret vel?el Per FA 00,22 brdofii is ergeotns tni.eesisv +2
ownersucks  14xw@89 rsgos gemia udwlo wsho pemiutll rdwehlo asmess +1

I feel the clearest way to understand this question/answer hasn't been stated yet. Recall that the cysts in PCOS are unruptured follicles. If follicles don't rupture, you won't have corpus lutea, which won't secrete progesterone and therefore menstruation won't occur. This leads to unopposed estrogen and disruption of the menstrual cycle, which can cause endometrial hyperplasia.

+20/- pg32(218)

The patient here is obese and has hirsutism. Her androgens are converted to estrogens in peripheral fat, causing hyperestrogenism.

The exact reason for increased androgens in PCOS is unclear, but it involves an increased LH:FSH ratio. Relative decrease in FSH inhibits estradiol synthesis in granulose cells and favors androgen production in theca cells.


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submitted by โˆ—pparalpha(93)
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linpmsaCicoto of C:OPS

ascvrCraiudloa tevnes

eypT 2 bdisteae slleitum

arnoEeimldt nrccaesharpeipaly=

neeadIrcs maercriiags tare

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