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Retired NBME 21 Answers

nbme21/Block 1/Question#12 (reveal difficulty score)
A 25-year-old nulligravid woman comes to the ...
Endometrial hyperplasia ๐Ÿ” / ๐Ÿ“บ / ๐ŸŒณ / ๐Ÿ“–
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 +3  upvote downvote
submitted by โˆ—mcl(671)
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SOCP is ssctodeiaa hwti omnblraa ndouicoprt fo exs osdt,srei ilgnniudc ysotduifcnn of grtnseoe iodocuntpr adn esrootpgrne.e yilcnChroal ldtaeeev sevell fo teeosnrg nca ucesa eltnmoredai .aylheiprasp

.n/i/o.lpscti/Cwbnt9vlg/..5im:twpasrc13he9M79w/mhc/Pn

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meningitis  yhW stni ti eiriosst?nmedo loduC oonseem elhp me uto no htsi? +2
meningitis  rr,oSy I saw gnocfnusi thwi rgehih irks rfo nmerdteoail rocmna.cia +1
vi_capsule  nrtsegoE is ielopsenrsb rfo clyclcia deeigbnl nad pani sodaietcsa hiwt sooeiistdremn ehcen enrpgoist si a ettrneamt mlyadt.io uBt erstoneg inst a risk cofatr rof .otdosnirisEem Rehatr rsteeh rtrdgeeaor lw,of amlapictet aostornnamiftr ect sioheret era nsipbeosrle for oiomstierdse.n +1
sympathetikey  fwT ouy get so nowrht off yb a tiupcre tath oyu n'otd rdae teh quiteons er.rpyopl +34
hyperfukus  nsinegiti@m kid fi u llist race llo utb yaswla go akbc ot edimootpcsio=seitncre etneilarmdo situse idosetu fo the utusre os ouy nca erlu ti out iscen edaeinrcs esortgne wludo esuca oyu to heva dnesorwe messiirondote or a teihrkc noe ubt ont ..uye.dcotiryl anc ees hte uclsmp fo het lscoiellf in teh evoisra fi ouy lkoo sruep oslec so that oalng hwit eht rpntieeantos stkae oyu to CPSO dna mntaiye oyu tond' evha a ybab ro asty ni het reorfiealvpit h(ragsoeneetps h)psae yuo etg eramteinold a&-otleiaslm-g-iogiytlher&iyuat-aftrtpenlp-;r;p iccmaoanr +2
lovebug  FA 2,190 pgae 631 +1
lovebug  Orteh aersnw e)MHsig smrdoney : idt ra of )1 irovaan mibaro,f 2) stieac,s )3 aprlelu e.ffionsu โ€Pilgulnโ€œ saeinostn in gonr.i FA 9,102 pg 263 +1
xw1984  s'Itn ooipnt G, otyaLamoiem ri,etu aotaidcses whti hhgi esrgeont llev?e erP FA 0022, bidfori is ngtrsoee venesisit. +2
ownersucks  wx9@184 ogssr iegma wodul whso emtpluli lohrwed smaess +1

I feel the clearest way to understand this question/answer hasn't been stated yet. Recall that the cysts in PCOS are unruptured follicles. If follicles don't rupture, you won't have corpus lutea, which won't secrete progesterone and therefore menstruation won't occur. This leads to unopposed estrogen and disruption of the menstrual cycle, which can cause endometrial hyperplasia.

+20/- pg32(218)

The patient here is obese and has hirsutism. Her androgens are converted to estrogens in peripheral fat, causing hyperestrogenism.

The exact reason for increased androgens in PCOS is unclear, but it involves an increased LH:FSH ratio. Relative decrease in FSH inhibits estradiol synthesis in granulose cells and favors androgen production in theca cells.


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 +0  upvote downvote
submitted by โˆ—pparalpha(93)
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lompsiCctonai fo OCPS:

uloarCdsavrcai setevn

epTy 2 etedabis itlleums

mailtnedEro canrce=shaeipralpy

Iesdencar egriciarsma trea

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