taediggityGoljan and FA mentioned this as Monday Disease for people who worked in industries that heavily used nitrates, where they would build tolerance during the week and then get a headache when they went back to work on Monday+12020-01-19T05:33:11Z
seracenWouldn't nitrates be a faster acting drug here? That was my take-away anyway. One is more acute, the other for long term maintenance.+12019-09-25T02:27:04Z
suckitnbmeI also believe it's because CCBs have minimal effect on venous beds and would not cause a significant decrease on preload.+2020-01-11T18:56:49Z
betodecrease of cardiac preload is another word of Venodilation, so Nitrates primarly venodilators. CCB dilate arteria more than veins+2020-02-07T09:27:16Z
thatyummysliceNitrates i believe! NO --> increased cGMP in vessel smooth muscle --> myosin light chain dephosphorylate --> vascular smooth muscle RELAX --> Dilate (primarily in venous) AKA more venous capacitance --> LOWER preload and workload for heart.+42019-06-02T03:13:20Z
marbledocThanks! Thought it was nitrates too from the Q stem. But had no clue it was notorious for headaches (only thought of hypotension, dizziness, etc) so doubted it all together. But you’re absolutely right apparently it’s the most common side effect!+2019-06-02T03:14:20Z
dr.xxPreviously, Ferid Murad et al. described that organic nitrates, such as nitroglycerine, induce vasodilation by release of nitric oxide, activating soluble guanylyl cyclase and subsequent cyclic guanosine monophosphate formation.7 These discoveries rendered Robert Furchgott, Louis Ignarro, and Ferid Murad the Nobel Prize in Physiology or Medicine in 1998.