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NBME 23 Answers

nbme23/Block 1/Question#7 (41.6 difficulty score)
Which of the following is present in integral ...
Transmembrane regionπŸ”,πŸ“Ί
tags: biochem cell_bio 

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submitted by step420(32),
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trleInga mrmebnea itrpoesn are ufodn itwihn hte salapm maebrmen and aspn teh lohwe nglhet o.rscas eTh sindei fo the emberman si vyer dooirbpcyhh ued to eht lgon caborn sianc.h nieesxvtE ihcyrobohdp asicneitnrto bwtenee teh npertoi dies nchai nda the pilid lasti lliw elhp hconar het pnoerit in het eamemrbn.

yb_26  O-linked glycosylation of secreted and membrane bound proteins is a post-translational event that takes place in the cis-Golgi compartment after N-glycosylation and folding of the protein +19  

submitted by irgunner(14),

I was thinking signal sequence on the N-terminal end that would direct the protein into the RER to be then implanted into the plasma membrane. I guess transmembrane region is the better more specific answer?

drdoom  A bilayer has hydrophobic tails (polar head + nonpolar tails). If the N-terminus could be embedded in there, it would also have to be hydrophobic; but if an N-terminus were hydrophobic, it wouldn't dissolve well in the cytosol (=mostly water). In fact, an N-terminus probably wouldn't dissolve at all. If it were hydrophobic, it would aggregate with other, nearby N-terminuses (or other hydrophobic motifs). But if that happened, shuttle proteins couldn't recognize N-terminuses in the first place (they wouldn't be sterically accessible), nor deliver them to the rER. +2  

submitted by yb_26(268),
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dke-Olin asnylyotocigl of certedes dan aemmernb uonbd sprtineo si a prss-aainttoltoanl tenev htat esatk calpe in het coGlii-gs ormmtpentac fraet csoyogtiy-llanN dan ongfldi fo het ernopti