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NBME 23 Answers

nbme23/Block 1/Question#7 (33.8 difficulty score)
Which of the following is present in integral ...
Transmembrane region🔍
tags: biochem cell_bio 

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 +3  upvote downvote
submitted by step420(33),
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Iltegrna mrbamnee eorisntp ear dnofu witinh hte ampsla ernbamem dan apsn the hwleo tenglh .oacsrs heT eisdni of het nerbmmea is yvre oocbpdhiyrh edu to eth nolg aorbcn nahsci. ntxevisEe dochyibprho cinaeiorsntt ewnebet teh oenpitr dise inahc dna eth idlpi alits illw hepl rhocan the reinpto ni the m.bnermea

yb_26  O-linked glycosylation of secreted and membrane bound proteins is a post-translational event that takes place in the cis-Golgi compartment after N-glycosylation and folding of the protein +9  



 +2  upvote downvote
submitted by irgunner(9),

I was thinking signal sequence on the N-terminal end that would direct the protein into the RER to be then implanted into the plasma membrane. I guess transmembrane region is the better more specific answer?

drdoom  A bilayer has hydrophobic tails (polar head + nonpolar tails). If the N-terminus could be embedded in there, it would also have to be hydrophobic; but if an N-terminus were hydrophobic, it wouldn't dissolve well in the cytosol (=mostly water). In fact, an N-terminus probably wouldn't dissolve at all. If it were hydrophobic, it would aggregate with other, nearby N-terminuses (or other hydrophobic motifs). But if that happened, shuttle proteins couldn't recognize N-terminuses in the first place (they wouldn't be sterically accessible), nor deliver them to the rER. +  



 -1  upvote downvote
submitted by yb_26(191),
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eiO-dnlk tlyalosioyngc of esdcetre nda bmremean nboud ortsnpie is a -ntiaaopstrstaonll evetn htta taeks aelpc in eht ciiGlogs- tmtcmnaerop ratef iyoNgotn-yllcas adn gdoflni fo het pintroe