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NBME 23 Answers

nbme23/Block 1/Question#7 (41.5 difficulty score)
Which of the following is present in integral ...
Transmembrane regionπŸ”,πŸ“Ί
tags: biochem cell_bio 

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submitted by step420(32),
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ganlrtIe enrmmabe ptsernoi rae uonfd iwthin the apamsl marnebem and naps eth whoel thngel s.aorcs ehT seindi of eth rnmmeeba is reyv bhrchdyoipo ued to teh logn arcbon s.iachn tsneivxEe pydhchirboo tarcisneinot tbeewen teh oprnite isde hncai dan het iidlp silta wlli phle aonhcr eht niprote ni het ae.bnmemr

yb_26  O-linked glycosylation of secreted and membrane bound proteins is a post-translational event that takes place in the cis-Golgi compartment after N-glycosylation and folding of the protein +19  

submitted by irgunner(14),

I was thinking signal sequence on the N-terminal end that would direct the protein into the RER to be then implanted into the plasma membrane. I guess transmembrane region is the better more specific answer?

drdoom  A bilayer has hydrophobic tails (polar head + nonpolar tails). If the N-terminus could be embedded in there, it would also have to be hydrophobic; but if an N-terminus were hydrophobic, it wouldn't dissolve well in the cytosol (=mostly water). In fact, an N-terminus probably wouldn't dissolve at all. If it were hydrophobic, it would aggregate with other, nearby N-terminuses (or other hydrophobic motifs). But if that happened, shuttle proteins couldn't recognize N-terminuses in the first place (they wouldn't be sterically accessible), nor deliver them to the rER. +2  

submitted by yb_26(268),
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n-kdeilO ciyslotnoalgy of dcetsere and embanerm nbduo posneitr is a tao-naraonlptltsis nveet taht askte alpce ni teh si-clGgio pamtnrmotce aerft -oansollygyticN dan ongdfil fo hte retnpoi