thotcandyLiterally had it on OI until I saw no family hx... Isn't it AUTOSOMAL DOMINANT?+12020-02-06T05:31:29Z
seagullExactly!! it's an autosomal dominate disease! +12019-06-04T23:22:35Z
emceeAutosomal dominant diseases are variably expressive. Still, I think this was a badly written question (should have given us some family history).+2019-06-08T04:19:20Z
wutuwantbruvAlso, FA says that fractures may occur during the birthing process, which is what I believe they were going for. I don't believe these findings would be seen at birth with any of the other choices.+2019-06-22T22:29:10Z
d_hollesYeah I thought I outsmarted NBME by selecting Rickets bc it said no family history ... guess I got played lol. +72019-07-04T22:40:57Z
jean_young2019Could it be a sporadic cases? Spontaneous Mutation
This is a change in a gene that occurs without an obvious cause, in a family where there is no history of the particular gene mutation. OI is inherited as an autosomal dominant trait. Approximately 35% of cases have no family history and are called "sporadic" cases. In sporadic cases, OI is believed to result from a spontaneous new mutation.