NBME 24 Answers ↦
I think there are two questions with this answer!!I was so scared :(
yep ---not IL-2 bc that stimulates Tcells and NK cells- I think I blacked out when I answered this question
I don’t think the NBME ever “intends” to write an ambiguous or poorly worded stem. What they want to do is write questions whose response choices are not “blatantly obvious” but which do have a single, “most correct” choice. That’s actually surprisingly difficult! If the correct choice were “obvious”, the test would not be doing a good job assessing anyone’s ability to make subtle judgment calls (an important skill, one might argue, in the morass that is the real world); this is also the reason they eschew “buzzwords”, generally. If a stem has two or more choices that are “equally correct”, the same lapse has occurred: they would be failing to assess the capacity to make subtle judgment calls.
The problem in AML (acute myeloid leukemia) is that precursor cells “get stuck” on their way to becoming (mature) granulocytes. Giving GM–CSF “pushes” them toward a more differentiated state and, because they divide as they mature, the cells become vulnerable to drugs that disrupt cell division (replication): “Granulocyte–macrophage colony-stimulating factor (GM–CSF) can stimulate proliferation of leukemic blasts and sensitize these cells to the cytotoxic effects of S-phase–specific drugs.” https://www.nature.com/articles/2402368